ChEMBL ligand: CHEMBL511115 (Ariflo, Cilomilast, SB 207499, SB-207499, SB207499)
Class 1 phosphodiesterase PDEB1 in Trypanosoma brucei [ChEMBL: CHEMBL2010636] [UniProtKB: Q8WQX9] There should be some charts here, you may need to enable JavaScript!
phosphodiesterase 2A/Phosphodiesterase 2A in Human [ChEMBL: CHEMBL2652] [GtoPdb: 1297] [UniProtKB: O00408] There should be some charts here, you may need to enable JavaScript!
phosphodiesterase 4A/Phosphodiesterase 4A in Human [ChEMBL: CHEMBL254] [GtoPdb: 1300] [UniProtKB: P27815] There should be some charts here, you may need to enable JavaScript!
phosphodiesterase 4B/Phosphodiesterase 4B in Human [ChEMBL: CHEMBL275] [GtoPdb: 1301] [UniProtKB: Q07343] phosphodiesterase 4B/Phosphodiesterase 4B in Rat [ChEMBL: CHEMBL3382] [GtoPdb: 1301] [UniProtKB: P14646] There should be some charts here, you may need to enable JavaScript!
phosphodiesterase 4C/Phosphodiesterase 4C in Human [ChEMBL: CHEMBL291] [GtoPdb: 1302] [UniProtKB: Q08493] There should be some charts here, you may need to enable JavaScript!
phosphodiesterase 4D/Phosphodiesterase 4D in Human [ChEMBL: CHEMBL288] [GtoPdb: 1303] [UniProtKB: Q08499] There should be some charts here, you may need to enable JavaScript!
phosphodiesterase 5A/Phosphodiesterase 5A in Human [ChEMBL: CHEMBL1827] [GtoPdb: 1304] [UniProtKB: O76074] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
Class 1 phosphodiesterase PDEB1 in Trypanosoma brucei (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2010636] [UniProtKB: Q8WQX9]
ChEMBL	Inhibition of Trypanosoma brucei recombinant PDEB1 pre-incubated for 5 mins prior to substrate addition	B	4.8	pIC50	16000	nM	IC50	Bioorg Med Chem Lett (2014) 24: 4084-4089 [PMID:25127163]
phosphodiesterase 2A/Phosphodiesterase 2A in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2652] [GtoPdb: 1297] [UniProtKB: O00408]
ChEMBL	Inhibition of human Phosphodiesterase 2 from peripheral blood mononuclear cells	B	5	pIC50	>10000	nM	IC50	Bioorg Med Chem Lett (2002) 12: 233-235 [PMID:11755362]
phosphodiesterase 4A/Phosphodiesterase 4A in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL254] [GtoPdb: 1300] [UniProtKB: P27815]
ChEMBL	Inhibitory concentration of compound against LPS- induced TNF-alpha production in whole human blood assay	F	4.74	pIC50	18000	nM	IC50	Bioorg Med Chem Lett (2002) 12: 1457-1461 [PMID:12031319]
ChEMBL	Inhibitory activity against Phosphodiesterase 4A (PDE4A) from human source expressed in Saccharomyces cerevisiae	B	6.39	pIC50	410	nM	IC50	J Med Chem (2000) 43: 675-682 [PMID:10691693]
ChEMBL	Inhibition of human recombinant PDE4A	B	6.4	pIC50	398	nM	IC50	J Med Chem (2021) 64: 1786-1815 [PMID:33569941]
ChEMBL	Inhibition of human Phosphodiesterase 4A from peripheral blood mononuclear cells	B	6.4	pIC50	398	nM	IC50	Bioorg Med Chem Lett (2002) 12: 233-235 [PMID:11755362]
ChEMBL	Inhibition of PDE4A (unknown origin)	B	6.8	pIC50	160	nM	IC50	Eur J Med Chem (2020) 204: 112492-112492 [PMID:32717478]
ChEMBL	Inhibition of human recombinant PDE4A	B	6.82	pIC50	150	nM	IC50	J Med Chem (2007) 50: 344-349 [PMID:17228876]
ChEMBL	Inhibition of human full length PDE4A4 expressed in baculovirus infected sf21 cells	B	7.21	pIC50	62	nM	IC50	Bioorg Med Chem Lett (2013) 23: 4308-4314 [PMID:23806553]
ChEMBL	Inhibition of human Phosphodiesterase 4A isoform using construct representing the common region of spliced variants expressed as GST-fusion proteins in Sf9 cells.	B	7.42	pIC50	38	nM	IC50	Bioorg Med Chem Lett (2002) 12: 3009-3013 [PMID:12270195]
ChEMBL	Inhibitory concentration against human PDE4A isoform using a construct representing the common region of spliced variants expressed as GST-fusion protein in Sf9 cells	B	7.42	pIC50	38	nM	IC50	Bioorg Med Chem Lett (2002) 12: 1457-1461 [PMID:12031319]
phosphodiesterase 4B/Phosphodiesterase 4B in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL275] [GtoPdb: 1301] [UniProtKB: Q07343]
ChEMBL	Inhibition of human Phosphodiesterase 4B from peripheral blood mononuclear cells	B	6.54	pIC50	288	nM	IC50	Bioorg Med Chem Lett (2002) 12: 233-235 [PMID:11755362]
ChEMBL	Inhibition of human recombinant PDE4B	B	6.54	pIC50	288	nM	IC50	J Med Chem (2021) 64: 1786-1815 [PMID:33569941]
ChEMBL	Inhibition of human recombinant PDE4B2 assessed as inhibition of cAMP hydrolysis by colorimetric assay	B	6.92	pIC50	120	nM	IC50	Bioorg Med Chem Lett (2014) 24: 249-253 [PMID:24300734]
ChEMBL	Inhibition of PDE4B (unknown origin)	B	6.92	pIC50	120	nM	IC50	Eur J Med Chem (2020) 204: 112492-112492 [PMID:32717478]
ChEMBL	Inhibition of human recombinant PDE4B2-mediated cAMP hydrolysis for 30 mins by colorimetric assay	B	6.92	pIC50	120	nM	IC50	Bioorg Med Chem Lett (2012) 22: 1523-1526 [PMID:22297114]
ChEMBL	Inhibition of human recombinant PDE4B by liquid scintillation counter method	B	7.02	pIC50	95	nM	IC50	Eur J Med Chem (2021) 226: 113877-113877 [PMID:34624823]
ChEMBL	Inhibition of PDE4B2 (unknown origin)	B	7.02	pIC50	95	nM	IC50	Bioorg Med Chem Lett (2014) 24: 249-253 [PMID:24300734]
ChEMBL	Inhibition of human recombinant PDE4B	B	7.08	pIC50	84	nM	IC50	J Med Chem (2007) 50: 344-349 [PMID:17228876]
ChEMBL	Inhibitory activity against recombinant phosphodiesterase 4B (PDE4B) of human mononuclear lymphocytes	B	7.15	pIC50	71	nM	IC50	Bioorg Med Chem Lett (2002) 12: 653-658 [PMID:11844693]
ChEMBL	Inhibition of human PDE4B1 incubated for 10 mins using cAMP and [3H]cAMP substrates	B	7.43	pIC50	37	nM	IC50	Bioorg Med Chem Lett (2009) 19: 3174-3176 [PMID:19447034]
ChEMBL	Inhibition of human His-tagged PDE4B catalytic domain expressed in Escherichia coli BL21-CodonPlus(DE3) cells using [3H]cAMP or [3H]cGMP as substrate incubated for 30 mins by scintillation counting method	B	7.6	pIC50	25	nM	IC50	J Med Chem (2016) 59: 7029-7065 [PMID:26908025]
ChEMBL	Inhibition of human PDE4B	B	7.6	pIC50	25	nM	IC50	Bioorg Med Chem (2010) 18: 2204-2218 [PMID:20188577]
phosphodiesterase 4B/Phosphodiesterase 4B in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3382] [GtoPdb: 1301] [UniProtKB: P14646]
ChEMBL	Inhibitory activity against Phosphodiesterase 4B (PDE4B) from rat source expressed in Saccharomyces cerevisiae	B	6.51	pIC50	310	nM	IC50	J Med Chem (2000) 43: 675-682 [PMID:10691693]
phosphodiesterase 4C/Phosphodiesterase 4C in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL291] [GtoPdb: 1302] [UniProtKB: Q08493]
ChEMBL	Inhibition of PDE4C (unknown origin)	B	5.06	pIC50	8700	nM	IC50	Eur J Med Chem (2020) 204: 112492-112492 [PMID:32717478]
ChEMBL	Inhibitory activity against Phosphodiesterase 4C (PDE4C) from human source expressed in Saccharomyces cerevisiae	B	6.08	pIC50	840	nM	IC50	J Med Chem (2000) 43: 675-682 [PMID:10691693]
ChEMBL	Inhibition of human Phosphodiesterase 4C from peripheral blood mononuclear cells	B	6.09	pIC50	813	nM	IC50	Bioorg Med Chem Lett (2002) 12: 233-235 [PMID:11755362]
ChEMBL	Inhibition of human recombinant PDE4C	B	6.09	pIC50	813	nM	IC50	J Med Chem (2021) 64: 1786-1815 [PMID:33569941]
ChEMBL	Inhibition of human recombinant PDE4C	B	6.21	pIC50	610	nM	IC50	J Med Chem (2007) 50: 344-349 [PMID:17228876]
phosphodiesterase 4D/Phosphodiesterase 4D in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL288] [GtoPdb: 1303] [UniProtKB: Q08499]
ChEMBL	Inhibition of human recombinant PDE4D3 using FAM-cAMP as substrate measured after 1 hr by IMAP TR-FRET assay	B	6.52	pIC50	300	nM	IC50	Eur J Med Chem (2020) 204: 112492-112492 [PMID:32717478]
ChEMBL	Inhibition of PDE4D (unknown origin) using cAMP as substrate	B	6.92	pIC50	120	nM	IC50	J Med Chem (2019) 62: 5579-5593 [PMID:31099559]
ChEMBL	Inhibitory activity against Phosphodiesterase 4D (PDE4D) from human source expressed in Saccharomyces cerevisiae	B	7.1	pIC50	79	nM	IC50	J Med Chem (2000) 43: 675-682 [PMID:10691693]
ChEMBL	Inhibition of human recombinant PDE4D	B	7.2	pIC50	63	nM	IC50	J Med Chem (2021) 64: 1786-1815 [PMID:33569941]
ChEMBL	Inhibition of human Phosphodiesterase 4D from peripheral blood mononuclear cells	B	7.2	pIC50	63	nM	IC50	Bioorg Med Chem Lett (2002) 12: 233-235 [PMID:11755362]
ChEMBL	Inhibition of human recombinant PDE4D	B	7.41	pIC50	39	nM	IC50	J Med Chem (2007) 50: 344-349 [PMID:17228876]
ChEMBL	Inhibition of human PDE4D3 incubated for 10 mins using cAMP and [3H]cAMP substrates	B	7.57	pIC50	27	nM	IC50	Bioorg Med Chem Lett (2009) 19: 3174-3176 [PMID:19447034]
ChEMBL	Inhibition of PDE4D (unknown origin)	B	7.89	pIC50	13	nM	IC50	Eur J Med Chem (2020) 204: 112492-112492 [PMID:32717478]
ChEMBL	Inhibition of human PDE4D	B	7.96	pIC50	11	nM	IC50	Bioorg Med Chem (2010) 18: 2204-2218 [PMID:20188577]
ChEMBL	Inhibition of human PDE4D catalytic domain using [3H]-cAMP or [3H]-cGMP incubated for 30 mins by scintillation counting method	B	7.96	pIC50	11	nM	IC50	EP-2674161-A1. FMO3 inhibitors for treating pain (2013)
ChEMBL	Inhibition of human His-tagged PDE4D catalytic domain expressed in Escherichia coli BL21-CodonPlus(DE3) cells using [3H]cAMP or [3H]cGMP as substrate incubated for 30 mins by scintillation counting method	B	7.96	pIC50	11	nM	IC50	J Med Chem (2016) 59: 7029-7065 [PMID:26908025]
phosphodiesterase 5A/Phosphodiesterase 5A in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1827] [GtoPdb: 1304] [UniProtKB: O76074]
ChEMBL	Inhibition of human Phosphodiesterase 5 from peripheral blood mononuclear cells	B	5	pIC50	>10000	nM	IC50	Bioorg Med Chem Lett (2002) 12: 233-235 [PMID:11755362]

ChEMBL data shown on this page come from version 34:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]