ChEMBL ligand: CHEMBL511115 (Ariflo, Cilomilast, SB 207499, SB-207499)
Class 1 phosphodiesterase PDEB1 in Trypanosoma brucei [ChEMBL: CHEMBL2010636] [UniProtKB: Q8WQX9] There should be some charts here, you may need to enable JavaScript!
phosphodiesterase 2A/Phosphodiesterase 2A in Human [ChEMBL: CHEMBL2652] [GtoPdb: 1297] [UniProtKB: O00408] There should be some charts here, you may need to enable JavaScript!
phosphodiesterase 4A/Phosphodiesterase 4A in Human [ChEMBL: CHEMBL254] [GtoPdb: 1300] [UniProtKB: P27815] There should be some charts here, you may need to enable JavaScript!
phosphodiesterase 4B/Phosphodiesterase 4B in Human [ChEMBL: CHEMBL275] [GtoPdb: 1301] [UniProtKB: Q07343] phosphodiesterase 4B/Phosphodiesterase 4B in Rat [ChEMBL: CHEMBL3382] [GtoPdb: 1301] [UniProtKB: P14646] There should be some charts here, you may need to enable JavaScript!
phosphodiesterase 4C/Phosphodiesterase 4C in Human [ChEMBL: CHEMBL291] [GtoPdb: 1302] [UniProtKB: Q08493] There should be some charts here, you may need to enable JavaScript!
phosphodiesterase 4D/Phosphodiesterase 4D in Human [ChEMBL: CHEMBL288] [GtoPdb: 1303] [UniProtKB: Q08499] There should be some charts here, you may need to enable JavaScript!
phosphodiesterase 5A/Phosphodiesterase 5A in Human [ChEMBL: CHEMBL1827] [GtoPdb: 1304] [UniProtKB: O76074] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
Class 1 phosphodiesterase PDEB1 in Trypanosoma brucei (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2010636] [UniProtKB: Q8WQX9]
ChEMBL	Inhibition of Trypanosoma brucei recombinant PDEB1 pre-incubated for 5 mins prior to substrate addition	B	4.8	pIC50	16000	nM	IC50	Bioorg. Med. Chem. Lett. (2014) 24: 4084-4089 [PMID:25127163]
phosphodiesterase 2A/Phosphodiesterase 2A in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2652] [GtoPdb: 1297] [UniProtKB: O00408]
ChEMBL	Inhibition of human Phosphodiesterase 2 from peripheral blood mononuclear cells	B	5	pIC50	>10000	nM	IC50	Bioorg. Med. Chem. Lett. (2002) 12: 233-235 [PMID:11755362]
phosphodiesterase 4A/Phosphodiesterase 4A in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL254] [GtoPdb: 1300] [UniProtKB: P27815]
ChEMBL	Inhibitory concentration of compound against LPS- induced TNF-alpha production in whole human blood assay	F	4.74	pIC50	18000	nM	IC50	Bioorg. Med. Chem. Lett. (2002) 12: 1457-1461 [PMID:12031319]
ChEMBL	Inhibitory activity against Phosphodiesterase 4A (PDE4A) from human source expressed in Saccharomyces cerevisiae	B	6.39	pIC50	410	nM	IC50	J. Med. Chem. (2000) 43: 675-682 [PMID:10691693]
ChEMBL	Inhibition of human Phosphodiesterase 4A from peripheral blood mononuclear cells	B	6.4	pIC50	398	nM	IC50	Bioorg. Med. Chem. Lett. (2002) 12: 233-235 [PMID:11755362]
ChEMBL	Inhibition of PDE4A (unknown origin)	B	6.8	pIC50	160	nM	IC50	Eur J Med Chem (2020) 204: 112492-112492 [PMID:32717478]
ChEMBL	Inhibition of human recombinant PDE4A	B	6.82	pIC50	150	nM	IC50	J. Med. Chem. (2007) 50: 344-349 [PMID:17228876]
ChEMBL	Inhibition of human full length PDE4A4 expressed in baculovirus infected sf21 cells	B	7.21	pIC50	62	nM	IC50	Bioorg. Med. Chem. Lett. (2013) 23: 4308-4314 [PMID:23806553]
ChEMBL	Inhibition of human Phosphodiesterase 4A isoform using construct representing the common region of spliced variants expressed as GST-fusion proteins in Sf9 cells.	B	7.42	pIC50	38	nM	IC50	Bioorg. Med. Chem. Lett. (2002) 12: 3009-3013 [PMID:12270195]
ChEMBL	Inhibitory concentration against human PDE4A isoform using a construct representing the common region of spliced variants expressed as GST-fusion protein in Sf9 cells	B	7.42	pIC50	38	nM	IC50	Bioorg. Med. Chem. Lett. (2002) 12: 1457-1461 [PMID:12031319]
phosphodiesterase 4B/Phosphodiesterase 4B in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL275] [GtoPdb: 1301] [UniProtKB: Q07343]
ChEMBL	Inhibition of human Phosphodiesterase 4B from peripheral blood mononuclear cells	B	6.54	pIC50	288	nM	IC50	Bioorg. Med. Chem. Lett. (2002) 12: 233-235 [PMID:11755362]
ChEMBL	Inhibition of PDE4B (unknown origin)	B	6.92	pIC50	120	nM	IC50	Eur J Med Chem (2020) 204: 112492-112492 [PMID:32717478]
ChEMBL	Inhibition of human recombinant PDE4B2-mediated cAMP hydrolysis for 30 mins by colorimetric assay	B	6.92	pIC50	120	nM	IC50	Bioorg. Med. Chem. Lett. (2012) 22: 1523-1526 [PMID:22297114]
ChEMBL	Inhibition of human recombinant PDE4B2 assessed as inhibition of cAMP hydrolysis by colorimetric assay	B	6.92	pIC50	120	nM	IC50	Bioorg. Med. Chem. Lett. (2014) 24: 249-253 [PMID:24300734]
ChEMBL	Inhibition of PDE4B2 (unknown origin)	B	7.02	pIC50	95	nM	IC50	Bioorg. Med. Chem. Lett. (2014) 24: 249-253 [PMID:24300734]
ChEMBL	Inhibition of human recombinant PDE4B	B	7.08	pIC50	84	nM	IC50	J. Med. Chem. (2007) 50: 344-349 [PMID:17228876]
ChEMBL	Inhibitory activity against recombinant phosphodiesterase 4B (PDE4B) of human mononuclear lymphocytes	B	7.15	pIC50	71	nM	IC50	Bioorg. Med. Chem. Lett. (2002) 12: 653-658 [PMID:11844693]
ChEMBL	Inhibition of human PDE4B1 incubated for 10 mins using cAMP and [3H]cAMP substrates	B	7.43	pIC50	37	nM	IC50	Bioorg. Med. Chem. Lett. (2009) 19: 3174-3176 [PMID:19447034]
ChEMBL	Inhibition of human His-tagged PDE4B catalytic domain expressed in Escherichia coli BL21-CodonPlus(DE3) cells using [3H]cAMP or [3H]cGMP as substrate incubated for 30 mins by scintillation counting method	B	7.6	pIC50	25	nM	IC50	J Med Chem (2016) 59: 7029-7065 [PMID:26908025]
ChEMBL	Inhibition of human PDE4B	B	7.6	pIC50	25	nM	IC50	Bioorg. Med. Chem. (2010) 18: 2204-2218 [PMID:20188577]
phosphodiesterase 4B/Phosphodiesterase 4B in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3382] [GtoPdb: 1301] [UniProtKB: P14646]
ChEMBL	Inhibitory activity against Phosphodiesterase 4B (PDE4B) from rat source expressed in Saccharomyces cerevisiae	B	6.51	pIC50	310	nM	IC50	J. Med. Chem. (2000) 43: 675-682 [PMID:10691693]
phosphodiesterase 4C/Phosphodiesterase 4C in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL291] [GtoPdb: 1302] [UniProtKB: Q08493]
ChEMBL	Inhibition of PDE4C (unknown origin)	B	5.06	pIC50	8700	nM	IC50	Eur J Med Chem (2020) 204: 112492-112492 [PMID:32717478]
ChEMBL	Inhibitory activity against Phosphodiesterase 4C (PDE4C) from human source expressed in Saccharomyces cerevisiae	B	6.08	pIC50	840	nM	IC50	J. Med. Chem. (2000) 43: 675-682 [PMID:10691693]
ChEMBL	Inhibition of human Phosphodiesterase 4C from peripheral blood mononuclear cells	B	6.09	pIC50	813	nM	IC50	Bioorg. Med. Chem. Lett. (2002) 12: 233-235 [PMID:11755362]
ChEMBL	Inhibition of human recombinant PDE4C	B	6.21	pIC50	610	nM	IC50	J. Med. Chem. (2007) 50: 344-349 [PMID:17228876]
phosphodiesterase 4D/Phosphodiesterase 4D in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL288] [GtoPdb: 1303] [UniProtKB: Q08499]
ChEMBL	Inhibition of human recombinant PDE4D3 using FAM-cAMP as substrate measured after 1 hr by IMAP TR-FRET assay	B	6.52	pIC50	300	nM	IC50	Eur J Med Chem (2020) 204: 112492-112492 [PMID:32717478]
ChEMBL	Inhibition of PDE4D (unknown origin) using cAMP as substrate	B	6.92	pIC50	120	nM	IC50	J Med Chem (2019) 62: 5579-5593 [PMID:31099559]
ChEMBL	Inhibitory activity against Phosphodiesterase 4D (PDE4D) from human source expressed in Saccharomyces cerevisiae	B	7.1	pIC50	79	nM	IC50	J. Med. Chem. (2000) 43: 675-682 [PMID:10691693]
ChEMBL	Inhibition of human Phosphodiesterase 4D from peripheral blood mononuclear cells	B	7.2	pIC50	63	nM	IC50	Bioorg. Med. Chem. Lett. (2002) 12: 233-235 [PMID:11755362]
ChEMBL	Inhibition of human recombinant PDE4D	B	7.41	pIC50	39	nM	IC50	J. Med. Chem. (2007) 50: 344-349 [PMID:17228876]
ChEMBL	Inhibition of human PDE4D3 incubated for 10 mins using cAMP and [3H]cAMP substrates	B	7.57	pIC50	27	nM	IC50	Bioorg. Med. Chem. Lett. (2009) 19: 3174-3176 [PMID:19447034]
ChEMBL	Inhibition of PDE4D (unknown origin)	B	7.89	pIC50	13	nM	IC50	Eur J Med Chem (2020) 204: 112492-112492 [PMID:32717478]
ChEMBL	Inhibition of human PDE4D	B	7.96	pIC50	11	nM	IC50	Bioorg. Med. Chem. (2010) 18: 2204-2218 [PMID:20188577]
ChEMBL	Inhibition of human PDE4D catalytic domain using [3H]-cAMP or [3H]-cGMP incubated for 30 mins by scintillation counting method	B	7.96	pIC50	11	nM	IC50	EP-2674161-A1. FMO3 inhibitors for treating pain (null)
ChEMBL	Inhibition of human His-tagged PDE4D catalytic domain expressed in Escherichia coli BL21-CodonPlus(DE3) cells using [3H]cAMP or [3H]cGMP as substrate incubated for 30 mins by scintillation counting method	B	7.96	pIC50	11	nM	IC50	J Med Chem (2016) 59: 7029-7065 [PMID:26908025]
phosphodiesterase 5A/Phosphodiesterase 5A in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1827] [GtoPdb: 1304] [UniProtKB: O76074]
ChEMBL	Inhibition of human Phosphodiesterase 5 from peripheral blood mononuclear cells	B	5	pIC50	>10000	nM	IC50	Bioorg. Med. Chem. Lett. (2002) 12: 233-235 [PMID:11755362]

ChEMBL data shown on this page come from version 31:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, Cibrián-Uhalte E, Davies M, Dedman N, Karlsson A, Magariños MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]