ChEMBL ligand: CHEMBL19449 (AV411, AV-411, Ibudilast, Ketas, MN-166)
Macrophage migration inhibitory factor in Human [ChEMBL: CHEMBL2085] [UniProtKB: P14174] There should be some charts here, you may need to enable JavaScript!
phosphodiesterase 4A/Phosphodiesterase 4A in Human [ChEMBL: CHEMBL254] [GtoPdb: 1300] [UniProtKB: P27815] There should be some charts here, you may need to enable JavaScript!
phosphodiesterase 4B/Phosphodiesterase 4B in Human [ChEMBL: CHEMBL275] [GtoPdb: 1301] [UniProtKB: Q07343] There should be some charts here, you may need to enable JavaScript!
phosphodiesterase 4C/Phosphodiesterase 4C in Human [ChEMBL: CHEMBL291] [GtoPdb: 1302] [UniProtKB: Q08493] There should be some charts here, you may need to enable JavaScript!
phosphodiesterase 4D/Phosphodiesterase 4D in Human [ChEMBL: CHEMBL288] [GtoPdb: 1303] [UniProtKB: Q08499] There should be some charts here, you may need to enable JavaScript!
phosphodiesterase 3A in Human [GtoPdb: 1298] [UniProtKB: Q14432] There should be some charts here, you may need to enable JavaScript!
phosphodiesterase 5A in Human [GtoPdb: 1304] [UniProtKB: O76074] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
Macrophage migration inhibitory factor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2085] [UniProtKB: P14174]
ChEMBL	Binding affinity to recombinant biotinylated human MIF expressed in Escherichia coli BL21 DE3 by surface plasmon resonance assay	B	5.85	pKd	1400	nM	Kd	ACS Med Chem Lett (2020) 11: 1843-1847 [PMID:33062162]
ChEMBL	Non-competitive inhibition of recombinant human MIF assessed as inhibition constant using varying levels of p-hydroxyphenylpyruvate as substrate by Lineweaver-Burk plot analysis	B	4.51	pKi	30900	nM	Ki	ACS Med Chem Lett (2020) 11: 1843-1847 [PMID:33062162]
phosphodiesterase 4A/Phosphodiesterase 4A in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL254] [GtoPdb: 1300] [UniProtKB: P27815]
ChEMBL	Inhibition of full-length PDE4A4 using cAMP as substrate by two-step radiochemical assay	B	5.89	pIC50	1300	nM	IC50	J. Med. Chem. (2011) 54: 3331-3347 [PMID:21456625]
ChEMBL	Inhibition of human PDE4A	B	7.27	pIC50	54	nM	IC50	J. Med. Chem. (2008) 51: 5471-5489 [PMID:18686943]
ChEMBL	Inhibition of human PDE4A expressed in insect sf9 cells using [3H]-cAMP as substrate	B	7.27	pIC50	54	nM	IC50	J Med Chem (2020) 63: 10594-10617 [PMID:32255344]
GtoPdb	-	-	7.27	pIC50	54	nM	IC50	J Med Chem (2008) 51: 5471-89 [PMID:18686943]
ChEMBL	Induction of SQSTM1-dependent intracellular redistribution of GFP-tagged PDE4A4 assessed as maximal accretion of enzyme into foci	B	6.05	pEC50	900	nM	EC50	J. Med. Chem. (2011) 54: 3331-3347 [PMID:21456625]
phosphodiesterase 4B/Phosphodiesterase 4B in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL275] [GtoPdb: 1301] [UniProtKB: Q07343]
ChEMBL	Inhibition of human PDE4B catalytic domain using cAMP/cGMP substrate	B	5.3	pIC50	5000	nM	IC50	Bioorg. Med. Chem. Lett. (2011) 21: 3307-3312 [PMID:21530250]
ChEMBL	Inhibition of human PDE4B	B	7.19	pIC50	65	nM	IC50	J. Med. Chem. (2008) 51: 5471-5489 [PMID:18686943]
ChEMBL	Inhibition of human PDE4B expressed in insect sf9 cells using [3H]-cAMP as substrate	B	7.19	pIC50	65	nM	IC50	J Med Chem (2020) 63: 10594-10617 [PMID:32255344]
GtoPdb	-	-	7.19	pIC50	65	nM	IC50	J Med Chem (2008) 51: 5471-89 [PMID:18686943]
phosphodiesterase 4C/Phosphodiesterase 4C in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL291] [GtoPdb: 1302] [UniProtKB: Q08493]
GtoPdb	-	-	6.62	pIC50	239	nM	IC50	J Med Chem (2008) 51: 5471-89 [PMID:18686943]
ChEMBL	Inhibition of human PDE4C	B	6.62	pIC50	239	nM	IC50	J. Med. Chem. (2008) 51: 5471-5489 [PMID:18686943]
ChEMBL	Inhibition of human PDE4C expressed in insect sf9 cells using [3H]-cAMP as substrate	B	6.62	pIC50	239	nM	IC50	J Med Chem (2020) 63: 10594-10617 [PMID:32255344]
phosphodiesterase 4D/Phosphodiesterase 4D in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL288] [GtoPdb: 1303] [UniProtKB: Q08499]
ChEMBL	Inhibition of human PDE4D	B	6.78	pIC50	166	nM	IC50	J. Med. Chem. (2008) 51: 5471-5489 [PMID:18686943]
ChEMBL	Inhibition of human PDE4D expressed in insect sf9 cells using [3H]-cAMP as substrate	B	6.78	pIC50	166	nM	IC50	J Med Chem (2020) 63: 10594-10617 [PMID:32255344]
phosphodiesterase 3A in Human [GtoPdb: 1298] [UniProtKB: Q14432]
GtoPdb	-	-	3.52	pIC50	299000	nM	IC50	Bioorg Med Chem Lett (2011) 21: 3307-12 [PMID:21530250]
phosphodiesterase 5A in Human [GtoPdb: 1304] [UniProtKB: O76074]
GtoPdb	-	-	3.99	pIC50	103000	nM	IC50	Bioorg Med Chem Lett (2011) 21: 3307-12 [PMID:21530250]

ChEMBL data shown on this page come from version 31:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, Cibrián-Uhalte E, Davies M, Dedman N, Karlsson A, Magariños MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]