ChEMBL ligand: CHEMBL101 (Ambene, Antadol, Artrizin, Azolid, Bizolin, Butacote, Butadion, Butadiona, Butaject, Butapirazol, Butatron, Butazolidin, Butoz, Buzon, Diphebuzol, Diphenylbutazone, Ecobutazone, Elmedal, Equipalazone, Equiphar, Exrheudon n, Fenibutazona, Fenibutol, Fenylbutazon, Flexazone, G-13871, Intrabutazone, Intrazone, Mepha-butazon, NSC-25134, Phebuzine, Phenylbutazone, Phenyzene, Pro-Bute, R-3-ZON, Robizone-v, Shigrodin, Tevcodyne, Uzone, Zolaphen)
COX-1 /Cyclooxygenase-1 in Human [ChEMBL: CHEMBL221] [GtoPdb: 1375] [UniProtKB: P23219] There should be some charts here, you may need to enable JavaScript!
Cyclooxygenase-2 in Dog [ChEMBL: CHEMBL4033] [UniProtKB: Q8SPQ9] There should be some charts here, you may need to enable JavaScript!
Nicotinate phosphoribosyltransferase in Human [ChEMBL: CHEMBL4523354] [UniProtKB: Q6XQN6] There should be some charts here, you may need to enable JavaScript!
Plasmodium falciparum [ChEMBL: CHEMBL364] There should be some charts here, you may need to enable JavaScript!
Organic anion transporter 3/Solute carrier family 22 member 8 in Human [ChEMBL: CHEMBL1641348] [GtoPdb: 1027] [UniProtKB: Q8TCC7] There should be some charts here, you may need to enable JavaScript!
COX-2 in Human [GtoPdb: 1376] [UniProtKB: P35354] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
COX-1 /Cyclooxygenase-1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL221] [GtoPdb: 1375] [UniProtKB: P23219]
GtoPdb	-	-	5.52	pIC50	3000	nM	IC50	Bioorg Med Chem Lett (1996) 6: 707-712
ChEMBL	Compound was evaluated for inhibition of Prostaglandin G/H synthase 1	B	5.52	pIC50	3000	nM	IC50	Bioorg Med Chem Lett (1996) 6: 707-712
Cyclooxygenase-2 in Dog (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4033] [UniProtKB: Q8SPQ9]
ChEMBL	Inhibitory activity of the compound against canine COX-2	B	5.42	pIC50	3790	nM	IC50	J Med Chem (2001) 44: 641-659 [PMID:11262075]
Nicotinate phosphoribosyltransferase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4523354] [UniProtKB: Q6XQN6]
ChEMBL	Inhibition of NAPRT (unknown origin)	B	10	pKi	0.1	nM	Ki	WO-2017162840-A1. Sensitization of cancer cells to nampt inhibitors by nicotinic acid phosphoribosyltransferase neutralization (null)
Plasmodium falciparum (target type: ORGANISM) [ChEMBL: CHEMBL364]
ChEMBL	Antiplasmodial activity against Plasmodium falciparum 7G8 after 72 hrs by SYBR green assay	F	4.9	pIC50	12589.25	nM	IC50	Nat Chem Biol (2009) 5: 765-771 [PMID:19734910]
ChEMBL	Antiplasmodial activity against Plasmodium falciparum D10 after 72 hrs by SYBR green assay	F	4.9	pIC50	12589.25	nM	IC50	Nat Chem Biol (2009) 5: 765-771 [PMID:19734910]
ChEMBL	Antiplasmodial activity against Plasmodium falciparum GB4 after 72 hrs by SYBR green assay	F	4.9	pIC50	12589.25	nM	IC50	Nat Chem Biol (2009) 5: 765-771 [PMID:19734910]
ChEMBL	Antiplasmodial activity against Plasmodium falciparum HB3 after 72 hrs by SYBR green assay	F	4.9	pIC50	12589.25	nM	IC50	Nat Chem Biol (2009) 5: 765-771 [PMID:19734910]
ChEMBL	Antiplasmodial activity against Plasmodium falciparum W2 after 72 hrs by SYBR green assay	F	4.9	pIC50	12589.25	nM	IC50	Nat Chem Biol (2009) 5: 765-771 [PMID:19734910]
ChEMBL	Antiplasmodial activity against Plasmodium falciparum 3D7 after 72 hrs by SYBR green assay	F	5	pIC50	10000	nM	IC50	Nat Chem Biol (2009) 5: 765-771 [PMID:19734910]
Organic anion transporter 3/Solute carrier family 22 member 8 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1641348] [GtoPdb: 1027] [UniProtKB: Q8TCC7]
ChEMBL	TP_TRANSPORTER: inhibition of MTX uptake in OAT3-expressing S2 cells	F	4.46	pKi	34700	nM	Ki	J Pharmacol Exp Ther (2002) 302: 666-671 [PMID:12130730]
COX-2 in Human [GtoPdb: 1376] [UniProtKB: P35354]
GtoPdb	-	-	3.55	pIC50	284000	nM	IC50	J Med Chem (1995) 38: 3895-901 [PMID:7562922]

ChEMBL data shown on this page come from version 33:

Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]