carmustine [Ligand Id: 6800] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL513 (BCNU, Becenun, Bicnu, Bischloroethyl nitrosourea, Camustine, Carmubris, Carmustine, DTI-015, FDA-0345, Gliadel, NSC-409962, SK-27702, SRI-1720)
  • glutathione-disulfide reductase/Glutathione reductase in Human [ChEMBL: CHEMBL2755] [GtoPdb: 2613] [UniProtKB: P00390]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
glutathione-disulfide reductase/Glutathione reductase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2755] [GtoPdb: 2613] [UniProtKB: P00390]
ChEMBL Inhibition of human recombinant glutathione reductase using glutathione as substrate preincubated for 30 mins by colorimetric assay B 5.09 pIC50 8100 nM IC50 Eur. J. Med. Chem. (2014) 71: 282-289 [PMID:24321832]

ChEMBL data shown on this page come from version 31:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, Cibrián-Uhalte E, Davies M, Dedman N, Karlsson A, Magariños MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]