Gene and Protein Information
Species	TM	AA	Chromosomal Location	Gene Symbol	Gene Name	Reference
Human	-	522	8p12	GSR	glutathione-disulfide reductase
Mouse	-	500	8 20.69 cM	Gsr	glutathione reductase
Rat	-	424	16q12.3	Gsr	glutathione-disulfide reductase

Previous and Unofficial Names

glutathione reductase, mitochondrial | glutathione reductase

Database Links
Alphafold	P00390 (Hs), P47791 (Mm), P70619 (Rn)
BRENDA	1.8.1.7
CATH/Gene3D	3.50.50.60, 3.30.390.30
ChEMBL Target	CHEMBL2755 (Hs), CHEMBL2366476 (Mm), CHEMBL3286088 (Rn)
DrugBank Target	P00390 (Hs)
Ensembl Gene	ENSG00000104687 (Hs), ENSMUSG00000031584 (Mm), ENSRNOG00000014915 (Rn)
Entrez Gene	2936 (Hs), 14782 (Mm), 116686 (Rn)
Human Protein Atlas	ENSG00000104687 (Hs)
KEGG Enzyme	1.8.1.7
KEGG Gene	hsa:2936 (Hs), mmu:14782 (Mm), rno:116686 (Rn)
OMIM	138300 (Hs)
Orphanet	ORPHA122298 (Hs)
Pharos	P00390 (Hs)
RefSeq Nucleotide	NM_000637 (Hs), NM_010344 (Mm), NM_053906 (Rn)
RefSeq Protein	NP_000628 (Hs), NP_034474 (Mm), NP_446358 (Rn)
SynPHARM	78934 (in complex with oxiglutatione)
UniProtKB	P00390 (Hs), P47791 (Mm), P70619 (Rn)
Wikipedia	GSR (Hs)

Selected 3D Structures
	Description:  Crystal Structure of human Glutathione Reductase complexed with a Fluoro-Analogue of the Menadione Derivative M5 PDB Id:  2GH5 Resolution:  1.7Å Species:  Human References:  1
	Description:  Catalytic cycle of human glutathione reductase near 1 A resolution PDB Id:  3DJG Resolution:  1.8Å Species:  Human References:  2

Enzyme Reaction
EC Number: 1.8.1.7

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Inhibitors
Key to terms and symbols	View all chemical structures	Click column headers to sort
Ligand Sp. Action Value Parameter Reference carmustine N/A Inhibition 4.2 pIC50 3 ⤷ pIC50 4.2 (IC50 7.1x10-5 M) [3] Description: The enzyme inhibition assay uses purified S. cerevisiae glutathione reductase oxiglutatione Hs Inhibition - - ⤷
View species-specific inhibitor tables
Inhibitor Comments
Apart from the CHEMBL listing of oxiglutatione as an approved drug acting at glutathione reductase and one PubMed reference describing a its use in a single clinical case study [4], there is very little information available about this drug and its mechanism of action.

Clinically-Relevant Mutations and Pathophysiology
Disease:  Hemolytic anemia due to glutathione reductase deficiency Orphanet: ORPHA90030