CZC 24832 [Ligand Id: 6653] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL2064571 |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/PI3-kinase p110-alpha subunit in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4005] [GtoPdb: 2153] [UniProtKB: P42336] | ||||||||
| ChEMBL | Inhibition of PI3Kalpha by high throughput chemoproteomics binding assay | B | 5 | pIC50 | >10000 | nM | IC50 | Bioorg Med Chem Lett (2012) 22: 5257-5263 [PMID:22819766] |
| ChEMBL | Inhibition of PI3Kalpha assessed as change in pIC50 by kinobeads assay | B | 5 | pIC50 | >10000 | nM | IC50 | Bioorg Med Chem Lett (2012) 22: 4613-4618 [PMID:22726925] |
| phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta/PI3-kinase p110-beta subunit in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3145] [GtoPdb: 2154] [UniProtKB: P42338] | ||||||||
| ChEMBL | Inhibition of PI3Kbeta by high throughput chemoproteomics binding assay | B | 5.9 | pIC50 | 1258.93 | nM | IC50 | Bioorg Med Chem Lett (2012) 22: 5257-5263 [PMID:22819766] |
| ChEMBL | Inhibition of PI3Kbeta assessed as change in pIC50 by kinobeads assay | B | 6 | pIC50 | 1000 | nM | IC50 | Bioorg Med Chem Lett (2012) 22: 4613-4618 [PMID:22726925] |
| phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta/PI3-kinase p110-delta subunit in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3130] [GtoPdb: 2155] [UniProtKB: O00329] | ||||||||
| ChEMBL | Inhibition of PI3Kdelta by high throughput chemoproteomics binding assay | B | 5.1 | pIC50 | 7943.28 | nM | IC50 | Bioorg Med Chem Lett (2012) 22: 5257-5263 [PMID:22819766] |
| ChEMBL | Inhibition of PI3Kdelta assessed as change in pIC50 by kinobeads assay | B | 5.1 | pIC50 | 7943.28 | nM | IC50 | Bioorg Med Chem Lett (2012) 22: 4613-4618 [PMID:22726925] |
| phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma/PI3-kinase p110-gamma subunit in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3267] [GtoPdb: 2156] [UniProtKB: P48736] | ||||||||
| GtoPdb | - | - | 7.7 | pKd | - | - | - | Nat Chem Biol (2012) 8: 576-82 [PMID:22544264] |
| GtoPdb | - | - | 7.57 | pIC50 | 27 | nM | IC50 | Nat Chem Biol (2012) 8: 576-82 [PMID:22544264] |
| ChEMBL | Inhibition of PI3Kgamma by high throughput chemoproteomics binding assay | B | 7.6 | pIC50 | 25.12 | nM | IC50 | Bioorg Med Chem Lett (2012) 22: 5257-5263 [PMID:22819766] |
| ChEMBL | Inhibition of PI3Kgamma by kinobeads assay | B | 7.6 | pIC50 | 25.12 | nM | IC50 | Bioorg Med Chem Lett (2012) 22: 4613-4618 [PMID:22726925] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
