RS-25344 [Ligand Id: 6557] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL1232082 |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| phosphodiesterase 4A/Phosphodiesterase 4A in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL254] [GtoPdb: 1300] [UniProtKB: P27815] | ||||||||
| GtoPdb | - | - | 7.2 | pIC50 | - | - | - | Cell Signal (1998) 10: 427-40 [PMID:9720765] |
| ChEMBL | Inhibition of full-length PDE4A4 using cAMP as substrate by two-step radiochemical assay | B | 7.66 | pIC50 | 22 | nM | IC50 | J Med Chem (2011) 54: 3331-3347 [PMID:21456625] |
| ChEMBL | Induction of SQSTM1-dependent intracellular redistribution of GFP-tagged PDE4A4 assessed as maximal accretion of enzyme into foci | B | 7.77 | pEC50 | 17 | nM | EC50 | J Med Chem (2011) 54: 3331-3347 [PMID:21456625] |
| phosphodiesterase 4B in Human [GtoPdb: 1301] [UniProtKB: Q07343] | ||||||||
| GtoPdb | - | - | 6.5 | pIC50 | - | - | - | Cell Signal (1998) 10: 427-40 [PMID:9720765] |
| phosphodiesterase 4C in Human [GtoPdb: 1302] [UniProtKB: Q08493] | ||||||||
| GtoPdb | - | - | 8.1 | pIC50 | - | - | - | Cell Signal (1998) 10: 427-40 [PMID:9720765] |
| phosphodiesterase 4D in Human [GtoPdb: 1303] [UniProtKB: Q08499] | ||||||||
| GtoPdb | - | - | 8.4 | pIC50 | - | - | - | Cell Signal (1998) 10: 427-40 [PMID:9720765] |
ChEMBL data shown on this page come from version 34:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
