dibenzoxazepine [Ligand Id: 6472] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL1085100 (Dibenz[B,F][1,4]Oxazepine, Dibenzo[B,F][1,4]Oxazepine) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| TRPA1/Transient receptor potential cation channel subfamily A member 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL6007] [GtoPdb: 485] [UniProtKB: O75762] | ||||||||
| ChEMBL | Activation of human TRPA1 channel | B | 6.51 | pEC50 | 308 | nM | EC50 | J Med Chem (2010) 53: 5085-5107 [PMID:20356305] |
| GtoPdb | Calcium imaging | - | 7.2 | pEC50 | - | - | - | Toxicol Appl Pharmacol (2008) 231: 150-6 [PMID:18501939] |
| ChEMBL | Activation of human TRPA1 channel | B | 9.52 | pEC50 | 0.3 | nM | EC50 | J Med Chem (2010) 53: 5085-5107 [PMID:20356305] |
| ChEMBL | Agonist activity at human TRPA1 expressed in T-REx-HEK293 cells assessed as increase of intracellular calcium level by FDSS assay | F | 9.52 | pEC50 | 0.3 | nM | EC50 | J Med Chem (2010) 53: 7011-7020 [PMID:20806939] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
