methyl p-hydroxybenzoate [Ligand Id: 6273] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL325372 (E218, Methylparaben, Methyl parahydroxybenzoate, Methyl p-hydroxybenzoate)
  • carbonic anhydrase 1/Carbonic anhydrase I in Human [ChEMBL: CHEMBL261] [GtoPdb: 2597] [UniProtKB: P00915]
  • This target only has 1 pki data point
  • 5.59
1 CHEMBL325372_lig_chart_1 Carbonic anhydrase I Human
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  • carbonic anhydrase 2/Carbonic anhydrase II in Human [ChEMBL: CHEMBL205] [GtoPdb: 3092] [UniProtKB: P00918]
  • This target only has 1 pki data point
  • 5.47
2 CHEMBL325372_lig_chart_2 Carbonic anhydrase II Human
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  • carbonic anhydrase 9/Carbonic anhydrase IX in Human [ChEMBL: CHEMBL3594] [GtoPdb: 3055] [UniProtKB: Q16790]
  • This target only has 1 pki data point
  • 5.26
3 CHEMBL325372_lig_chart_3 Carbonic anhydrase IX Human
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  • carbonic anhydrase 7/Carbonic anhydrase VII in Human [ChEMBL: CHEMBL2326] [GtoPdb: 2749] [UniProtKB: P43166]
  • This target only has 1 pki data point
  • 6.11
4 CHEMBL325372_lig_chart_4 Carbonic anhydrase VII Human
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  • carbonic anhydrase 12/Carbonic anhydrase XII in Human [ChEMBL: CHEMBL3242] [GtoPdb: 2747] [UniProtKB: O43570]
  • This target only has 1 pki data point
  • 6.09
5 CHEMBL325372_lig_chart_5 Carbonic anhydrase XII Human
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  • carbonic anhydrase 14/Carbonic anhydrase XIV in Human [ChEMBL: CHEMBL3510] [GtoPdb: 2598] [UniProtKB: Q9ULX7]
  • This target only has 1 pki data point
  • 5.39
6 CHEMBL325372_lig_chart_6 Carbonic anhydrase XIV Human
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  • xanthine dehydrogenase/Xanthine dehydrogenase in Human [ChEMBL: CHEMBL1929] [GtoPdb: 2646] [UniProtKB: P47989]
  • This target only has 0 pki data point
  • 0
7 CHEMBL325372_lig_chart_7 Xanthine dehydrogenase Human
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  • TRPA1 in Mouse [GtoPdb: 485] [UniProtKB: Q8BLA8]
  • This target only has 0 pki data point
  • 0
8 CHEMBL325372_lig_chart_8 TRPA1 Mouse
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
carbonic anhydrase 1/Carbonic anhydrase I in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL261] [GtoPdb: 2597] [UniProtKB: P00915]
ChEMBL Inhibition of human carbonic anhydrase 1 preincubated for 15 mins by CO2 hydration stopped-flow assay B 5.59 pKi 2600 nM Ki Bioorg. Med. Chem. (2013) 21: 1564-1569 [PMID:22668600]
carbonic anhydrase 2/Carbonic anhydrase II in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL205] [GtoPdb: 3092] [UniProtKB: P00918]
ChEMBL Inhibition of human carbonic anhydrase 2 preincubated for 15 mins by CO2 hydration stopped-flow assay B 5.47 pKi 3400 nM Ki Bioorg. Med. Chem. (2013) 21: 1564-1569 [PMID:22668600]
carbonic anhydrase 9/Carbonic anhydrase IX in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3594] [GtoPdb: 3055] [UniProtKB: Q16790]
ChEMBL Inhibition of human carbonic anhydrase 9 preincubated for 15 mins by CO2 hydration stopped-flow assay B 5.26 pKi 5500 nM Ki Bioorg. Med. Chem. (2013) 21: 1564-1569 [PMID:22668600]
carbonic anhydrase 7/Carbonic anhydrase VII in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2326] [GtoPdb: 2749] [UniProtKB: P43166]
ChEMBL Inhibition of human carbonic anhydrase 7 preincubated for 15 mins by CO2 hydration stopped-flow assay B 6.11 pKi 780 nM Ki Bioorg. Med. Chem. (2013) 21: 1564-1569 [PMID:22668600]
carbonic anhydrase 12/Carbonic anhydrase XII in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3242] [GtoPdb: 2747] [UniProtKB: O43570]
ChEMBL Inhibition of human carbonic anhydrase 12 preincubated for 15 mins by CO2 hydration stopped-flow assay B 6.09 pKi 820 nM Ki Bioorg. Med. Chem. (2013) 21: 1564-1569 [PMID:22668600]
carbonic anhydrase 14/Carbonic anhydrase XIV in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3510] [GtoPdb: 2598] [UniProtKB: Q9ULX7]
ChEMBL Inhibition of human carbonic anhydrase 14 preincubated for 15 mins by CO2 hydration stopped-flow assay B 5.39 pKi 4100 nM Ki Bioorg. Med. Chem. (2013) 21: 1564-1569 [PMID:22668600]
xanthine dehydrogenase/Xanthine dehydrogenase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1929] [GtoPdb: 2646] [UniProtKB: P47989]
ChEMBL Inhibition of xanthine oxidase-mediated formation of uric acid by spectrophotometry B 4.3 pIC50 >50000 nM IC50 J. Nat. Prod. (2002) 65: 1526-1529 [PMID:12444671]
TRPA1 in Mouse [GtoPdb: 485] [UniProtKB: Q8BLA8]
GtoPdb Patch clamp - 2.4 pEC50 - - - Br J Pharmacol (2007) 151: 153-60 [PMID:17351650]

ChEMBL data shown on this page come from version 28:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, CibriƔn-Uhalte E, Davies M, Dedman N, Karlsson A, MagariƱos MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]