ChEMBL ligand: CHEMBL573578
Calmodulin-domain protein kinase 1 in Toxoplasma gondii [ChEMBL: CHEMBL1781862] [UniProtKB: Q9BJF5] There should be some charts here, you may need to enable JavaScript!
calcium/calmodulin-dependent protein kinase II alpha subunit/CaM kinase II alpha in Human [ChEMBL: CHEMBL4147] [GtoPdb: 1555] [UniProtKB: Q9UQM7] There should be some charts here, you may need to enable JavaScript!
protein kinase, cAMP-dependent, catalytic, alpha subunit/cAMP-dependent protein kinase alpha-catalytic subunit in Human [ChEMBL: CHEMBL4101] [GtoPdb: 1476] [UniProtKB: P17612] There should be some charts here, you may need to enable JavaScript!
mitogen-activated protein kinase 8/c-Jun N-terminal kinase 1 in Human [ChEMBL: CHEMBL2276] [GtoPdb: 1496] [UniProtKB: P45983] There should be some charts here, you may need to enable JavaScript!
cyclin dependent kinase 2/Cyclin-dependent kinase 2 in Human [ChEMBL: CHEMBL301] [GtoPdb: 1973] [UniProtKB: P24941] There should be some charts here, you may need to enable JavaScript!
protein kinase D1/Protein kinase C mu in Human [ChEMBL: CHEMBL3863] [GtoPdb: 1489] [UniProtKB: Q15139] There should be some charts here, you may need to enable JavaScript!
protein kinase D3/Protein kinase C nu in Human [ChEMBL: CHEMBL2595] [GtoPdb: 2174] [UniProtKB: O94806] There should be some charts here, you may need to enable JavaScript!
protein kinase D2/Serine/threonine-protein kinase D2 in Human [ChEMBL: CHEMBL4900] [GtoPdb: 2173] [UniProtKB: Q9BZL6] There should be some charts here, you may need to enable JavaScript!
receptor interacting serine/threonine kinase 2/Serine/threonine-protein kinase RIPK2 in Human [ChEMBL: CHEMBL5014] [GtoPdb: 2190] [UniProtKB: O43353] There should be some charts here, you may need to enable JavaScript!
ABL proto-oncogene 1, non-receptor tyrosine kinase/Tyrosine-protein kinase ABL in Human [ChEMBL: CHEMBL1862] [GtoPdb: 1923] [UniProtKB: P00519] There should be some charts here, you may need to enable JavaScript!
C-terminal Src kinase/Tyrosine-protein kinase CSK in Human [ChEMBL: CHEMBL2634] [GtoPdb: 1994] [UniProtKB: P41240] There should be some charts here, you may need to enable JavaScript!
FYN proto-oncogene, Src family tyrosine kinase/Tyrosine-protein kinase FYN in Human [ChEMBL: CHEMBL1841] [GtoPdb: 2026] [UniProtKB: P06241] There should be some charts here, you may need to enable JavaScript!
LCK proto-oncogene, Src family tyrosine kinase/Tyrosine-protein kinase LCK in Mouse [ChEMBL: CHEMBL2480] [GtoPdb: 2053] [UniProtKB: P06240] There should be some charts here, you may need to enable JavaScript!
Tyrosine-protein kinase SRC in Chicken [ChEMBL: CHEMBL3655] [UniProtKB: P00523] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
Calmodulin-domain protein kinase 1 in Toxoplasma gondii (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1781862] [UniProtKB: Q9BJF5]
ChEMBL	Inhibition of Toxoplasma gondii recombinant N-terminal hexahistidine tagged CDPK1 expressed in Escherichia coli using syntide-2 as substrate after 90 mins by luminescence based scintillation counter	B	7.51	pIC50	31	nM	IC50	ACS Med Chem Lett (2010) 1: 331-335 [PMID:21116453]
calcium/calmodulin-dependent protein kinase II alpha subunit/CaM kinase II alpha in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4147] [GtoPdb: 1555] [UniProtKB: Q9UQM7]
ChEMBL	Inhibition of CAMK2 F89G mutant	B	8.1	pIC50	8	nM	IC50	Nat Chem Biol (2005) 1: 130-142 [PMID:16408016]
protein kinase, cAMP-dependent, catalytic, alpha subunit/cAMP-dependent protein kinase alpha-catalytic subunit in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4101] [GtoPdb: 1476] [UniProtKB: P17612]
ChEMBL	Inhibition of PKA in the presence of 20uM ATP	B	6.3	pIC50	500	nM	IC50	Biochem J (2007) 408: 297-315 [PMID:17850214]
mitogen-activated protein kinase 8/c-Jun N-terminal kinase 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2276] [GtoPdb: 1496] [UniProtKB: P45983]
ChEMBL	Inhibition of JNK-M108A in the presence of 20uM ATP	B	6.6	pIC50	250	nM	IC50	Biochem J (2007) 408: 297-315 [PMID:17850214]
ChEMBL	Inhibition of JNK-M108G in the presence of 20uM ATP	B	6.85	pIC50	140	nM	IC50	Biochem J (2007) 408: 297-315 [PMID:17850214]
cyclin dependent kinase 2/Cyclin-dependent kinase 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL301] [GtoPdb: 1973] [UniProtKB: P24941]
ChEMBL	Inhibition of wild type CDK2	B	4.54	pIC50	29000	nM	IC50	Nat Chem Biol (2005) 1: 130-142 [PMID:16408016]
ChEMBL	Inhibition of CDK2 F80G mutant	B	8.3	pIC50	5	nM	IC50	Nat Chem Biol (2005) 1: 130-142 [PMID:16408016]
protein kinase D1/Protein kinase C mu in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3863] [GtoPdb: 1489] [UniProtKB: Q15139]
ChEMBL	Inhibition of recombinant FLAG-tagged PKD1 (unknown origin) expressed in HEK293T cells using Syntide-2 as substrate measured after 15 mins by ADP-Glo assay	B	5.99	pIC50	1013	nM	IC50	Eur J Med Chem (2020) 205: 112638-112638 [PMID:32835918]
ChEMBL	Inhibition of PKD1 in the presence of 50uM ATP	B	6.6	pIC50	250	nM	IC50	Biochem J (2007) 408: 297-315 [PMID:17850214]
protein kinase D3/Protein kinase C nu in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2595] [GtoPdb: 2174] [UniProtKB: O94806]
ChEMBL	Inhibition of recombinant FLAG-tagged PKD3 (unknown origin) expressed in HEK293T cells using Syntide-2 as substrate measured after 15 mins by ADP-Glo assay	B	6.21	pIC50	616	nM	IC50	Eur J Med Chem (2020) 205: 112638-112638 [PMID:32835918]
protein kinase D2/Serine/threonine-protein kinase D2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4900] [GtoPdb: 2173] [UniProtKB: Q9BZL6]
ChEMBL	Inhibition of recombinant FLAG-tagged PKD2 (unknown origin) expressed in HEK293T cells using Syntide-2 as substrate measured after 15 mins by ADP-Glo assay	B	6.1	pIC50	786	nM	IC50	Eur J Med Chem (2020) 205: 112638-112638 [PMID:32835918]
receptor interacting serine/threonine kinase 2/Serine/threonine-protein kinase RIPK2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5014] [GtoPdb: 2190] [UniProtKB: O43353]
ChEMBL	Inhibition of RIP2 in the presence of 100uM ATP	B	6.89	pIC50	130	nM	IC50	Biochem J (2007) 408: 297-315 [PMID:17850214]
ABL proto-oncogene 1, non-receptor tyrosine kinase/Tyrosine-protein kinase ABL in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1862] [GtoPdb: 1923] [UniProtKB: P00519]
ChEMBL	Inhibition of wild type c-Abl	B	5.47	pIC50	3400	nM	IC50	Nat Chem Biol (2005) 1: 130-142 [PMID:16408016]
ChEMBL	Inhibition of c-Abl T315A mutant	B	6.92	pIC50	120	nM	IC50	Nat Chem Biol (2005) 1: 130-142 [PMID:16408016]
C-terminal Src kinase/Tyrosine-protein kinase CSK in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2634] [GtoPdb: 1994] [UniProtKB: P41240]
ChEMBL	Inhibition of CSK in the presence of 20uM ATP	B	6.29	pIC50	510	nM	IC50	Biochem J (2007) 408: 297-315 [PMID:17850214]
FYN proto-oncogene, Src family tyrosine kinase/Tyrosine-protein kinase FYN in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1841] [GtoPdb: 2026] [UniProtKB: P06241]
ChEMBL	Inhibition of wild type c-Fyn	B	6	pIC50	1000	nM	IC50	Nat Chem Biol (2005) 1: 130-142 [PMID:16408016]
LCK proto-oncogene, Src family tyrosine kinase/Tyrosine-protein kinase LCK in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2480] [GtoPdb: 2053] [UniProtKB: P06240]
ChEMBL	Inhibition of Lck in the presence of 50uM ATP	B	6.34	pIC50	460	nM	IC50	Biochem J (2007) 408: 297-315 [PMID:17850214]
Tyrosine-protein kinase SRC in Chicken (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3655] [UniProtKB: P00523]
ChEMBL	Inhibition of Src in the presence of 50uM ATP	B	6.21	pIC50	620	nM	IC50	Biochem J (2007) 408: 297-315 [PMID:17850214]

ChEMBL data shown on this page come from version 33:

Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]