ChEMBL ligand: CHEMBL257167
inhibitor of nuclear factor kappa B kinase subunit beta/Inhibitor of nuclear factor kappa B kinase beta subunit in Human [ChEMBL: CHEMBL1991] [GtoPdb: 2039] [UniProtKB: O14920] There should be some charts here, you may need to enable JavaScript!
eukaryotic translation initiation factor 2 alpha kinase 2/Interferon-induced, double-stranded RNA-activated protein kinase in Human [ChEMBL: CHEMBL5785] [GtoPdb: 2016] [UniProtKB: P19525] There should be some charts here, you may need to enable JavaScript!
Janus kinase 2/Tyrosine-protein kinase JAK2 in Human [ChEMBL: CHEMBL2971] [GtoPdb: 2048] [UniProtKB: O60674] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
inhibitor of nuclear factor kappa B kinase subunit beta/Inhibitor of nuclear factor kappa B kinase beta subunit in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1991] [GtoPdb: 2039] [UniProtKB: O14920]
ChEMBL	Inhibition of IKK-beta	B	7.7	pIC50	19.95	nM	IC50	Bioorg Med Chem Lett (2011) 21: 2255-2258 [PMID:21429745]
ChEMBL	Inhibition of IKK-beta	B	7.71	pIC50	19.5	nM	IC50	J Med Chem (2008) 51: 7898-7914 [PMID:19035792]
ChEMBL	Inhibition of IKK beta at 300 uM by K-ELISA	B	7.74	pIC50	18	nM	IC50	J Nat Prod (2008) 71: 106-111 [PMID:18088098]
ChEMBL	Inhibition of IKK-beta by TR-FRET assay	B	7.74	pIC50	18	nM	IC50	Bioorg Med Chem (2009) 17: 2759-2766 [PMID:19285872]
GtoPdb	FRET measurement using recombinant human IKK2 (residues 1-756)	-	7.75	pIC50	17.9	nM	IC50	J Pharmacol Exp Ther (2005) 312: 373-81 [PMID:15316093]
eukaryotic translation initiation factor 2 alpha kinase 2/Interferon-induced, double-stranded RNA-activated protein kinase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5785] [GtoPdb: 2016] [UniProtKB: P19525]
ChEMBL	Inhibition of human recombinant PKR autophosphorylation using poly[I:C] after 10 mins by luminescent assay	B	6.6	pIC50	250	nM	IC50	Bioorg Med Chem Lett (2011) 21: 4108-4114 [PMID:21632247]
Janus kinase 2/Tyrosine-protein kinase JAK2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2971] [GtoPdb: 2048] [UniProtKB: O60674]
ChEMBL	Binding affinity to human JAK2	B	7.66	pKd	22	nM	Kd	J Med Chem (2008) 51: 7898-7914 [PMID:19035792]
ChEMBL	Inhibition of JAK2	B	8.3	pKi	5	nM	Ki	J Med Chem (2008) 51: 7898-7914 [PMID:19035792]

ChEMBL data shown on this page come from version 33:

Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]