Gö 6976 [Ligand Id: 5973] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL302449 (Go-6976) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| cAMP-dependent protein kinase alpha-catalytic subunit in Bovine (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2654] [UniProtKB: P00517] | ||||||||
| ChEMBL | In vitro for inhibitory activity against cAMP-dependent protein kinase from bovine heart (A-kinase) | B | 4 | pIC50 | >100000 | nM | IC50 | Bioorg Med Chem Lett (1993) 3: 1959-1964 |
| cGMP-dependent protein kinase 1 alpha in Bovine (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3183] [UniProtKB: P00516] | ||||||||
| ChEMBL | In vitro for inhibitory activity against cGMP-dependent protein kinase from bovine lung (G-kinase) | B | 5.21 | pIC50 | 6200 | nM | IC50 | Bioorg Med Chem Lett (1993) 3: 1959-1964 |
| ChEMBL | Tested for inhibition of cGMP-dependent protein kinase from bovine lung | B | 5.21 | pIC50 | 6200 | nM | IC50 | Bioorg Med Chem Lett (1995) 5: 55-60 |
| Myosin light chain kinase, smooth muscle in Chicken (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3062] [UniProtKB: P11799] | ||||||||
| ChEMBL | In vitro for inhibitory activity against myosin light-chain kinase from chicken gizzard (M-kinase) | B | 5.24 | pIC50 | 5800 | nM | IC50 | Bioorg Med Chem Lett (1993) 3: 1959-1964 |
| myosin light chain kinase/Myosin light chain kinase, smooth muscle in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2428] [GtoPdb: 1552] [UniProtKB: Q15746] | ||||||||
| ChEMBL | Tested for inhibition of Myosin light chain kinase from chicken gizzard | B | 5.24 | pIC50 | 5800 | nM | IC50 | Bioorg Med Chem Lett (1995) 5: 55-60 |
| sirtuin 2/NAD-dependent deacetylase sirtuin 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4462] [GtoPdb: 2708] [UniProtKB: Q8IXJ6] | ||||||||
| ChEMBL | Inhibition of human recombinant SIRT2 | B | 4 | pIC50 | >100000 | nM | IC50 | J Med Chem (2006) 49: 7307-7316 [PMID:17149860] |
| protein kinase C alpha/Protein kinase C alpha in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL299] [GtoPdb: 1482] [UniProtKB: P17252] | ||||||||
| ChEMBL | Inhibition of PKCalpha by TR-FRET assay | B | 8.43 | pIC50 | 3.7 | nM | IC50 | J Med Chem (2010) 53: 5400-5421 [PMID:20684591] |
| ChEMBL | Inhibition of PKCalpha | B | 8.64 | pIC50 | 2.3 | nM | IC50 | J Biol Chem (2007) 282: 15208-15216 [PMID:17395590] |
| GtoPdb | - | - | 8.64 | pIC50 | 2.3 | nM | IC50 | J Biol Chem (1993) 268: 9194-7 [PMID:8486620] |
| ChEMBL | Inhibition of PKCalpha | B | 8.7 | pIC50 | 2 | nM | IC50 | Proc Natl Acad Sci U S A (2007) 104: 20523-20528 [PMID:18077363] |
| protein kinase C beta/Protein kinase C beta in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3045] [GtoPdb: 1483] [UniProtKB: P05771] | ||||||||
| ChEMBL | Inhibition of PKCbeta1 | B | 8.21 | pIC50 | 6.2 | nM | IC50 | J Biol Chem (2007) 282: 15208-15216 [PMID:17395590] |
| ChEMBL | Inhibition of PKCbeta | B | 8.7 | pIC50 | 2 | nM | IC50 | Proc Natl Acad Sci U S A (2007) 104: 20523-20528 [PMID:18077363] |
| protein kinase C delta/Protein kinase C delta in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2996] [GtoPdb: 1485] [UniProtKB: Q05655] | ||||||||
| ChEMBL | Inhibition of PKCdelta by TR-FRET assay | B | 6.35 | pIC50 | 446 | nM | IC50 | J Med Chem (2010) 53: 5400-5421 [PMID:20684591] |
| protein kinase C gamma/Protein kinase C gamma in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2938] [GtoPdb: 1484] [UniProtKB: P05129] | ||||||||
| ChEMBL | Inhibition of PKCgamma | B | 8.7 | pIC50 | 2 | nM | IC50 | Proc Natl Acad Sci U S A (2007) 104: 20523-20528 [PMID:18077363] |
| protein kinase D1/Protein kinase C mu in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3863] [GtoPdb: 1489] [UniProtKB: Q15139] | ||||||||
| ChEMBL | Inhibition of PKD1 assessed as HDAC5 neuclear export | B | 7.21 | pIC50 | 62 | nM | IC50 | J Med Chem (2010) 53: 5400-5421 [PMID:20684591] |
| ChEMBL | Inhibition of PKD1 by TR-FRET assay | B | 7.57 | pIC50 | 27 | nM | IC50 | J Med Chem (2010) 53: 5400-5421 [PMID:20684591] |
| GtoPdb | - | - | 7.7 | pIC50 | 20 | nM | IC50 | FEBS Lett (1996) 392: 77-80 [PMID:8772178] |
| polo like kinase 4/Serine/threonine-protein kinase PLK4 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3788] [GtoPdb: 2171] [UniProtKB: O00444] | ||||||||
| ChEMBL | Inhibition of human PLK4 | B | 8.47 | pKi | 3.4 | nM | Ki | J Med Chem (2013) 56: 6069-6087 [PMID:23829549] |
| BLK proto-oncogene, Src family tyrosine kinase/Tyrosine-protein kinase BLK in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3343] [GtoPdb: 1940] [UniProtKB: P16277] | ||||||||
| ChEMBL | Tested for inhibition of general tyrosine-specific protein kinase activity from murine B cell lysate | B | 5 | pIC50 | >10000 | nM | IC50 | Bioorg Med Chem Lett (1995) 5: 55-60 |
| fms related receptor tyrosine kinase 3 in Human [GtoPdb: 1807] [UniProtKB: P36888] | ||||||||
| GtoPdb | Inhibitory activity against recombinant FLT3 in an in vitro kinase assay. | - | 9.15 | pIC50 | 0.7 | nM | IC50 | Biochem Pharmacol (2014) 90: 16-24 [PMID:24735609] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
