Flt-3 inhibitor II [Ligand Id: 5971] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL377193 |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| platelet derived growth factor receptor beta/platelet derived growth factor receptor alpha in Human [GtoPdb: 1804, 1803] [UniProtKB: P09619, P16234] | ||||||||
| GtoPdb | - | - | 6.77 | pIC50 | 171 | nM | IC50 | J Med Chem (2006) 49: 3101-15 [PMID:16722630] |
| platelet derived growth factor receptor beta/platelet derived growth factor receptor alpha/Platelet-derived growth factor receptor in Mouse (target type: PROTEIN COMPLEX) [ChEMBL: CHEMBL2096980] [GtoPdb: 1804, 1803] [UniProtKB: P05622, P26618] | ||||||||
| ChEMBL | Inhibition of endogenous PDGFR in Swiss3T3 fibroblasts | B | 6.52 | pIC50 | 300 | nM | IC50 | J Med Chem (2006) 49: 3101-3115 [PMID:16722630] |
| platelet derived growth factor receptor beta/Platelet-derived growth factor receptor beta in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1913] [GtoPdb: 1804] [UniProtKB: P09619] | ||||||||
| ChEMBL | Inhibition of human PDGFR beta | B | 6.77 | pIC50 | 171 | nM | IC50 | J Med Chem (2006) 49: 3101-3115 [PMID:16722630] |
| GtoPdb | - | - | 6.77 | pIC50 | 171 | nM | IC50 | J Med Chem (2006) 49: 3101-15 [PMID:16722630] |
| KIT proto-oncogene, receptor tyrosine kinase/Stem cell growth factor receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1936] [GtoPdb: 1805] [UniProtKB: P10721] | ||||||||
| ChEMBL | Inhibition of DNA synthesis in IL3 dependent FDC-P1 cells expressing wild-type KIT | F | 6.3 | pIC50 | 500 | nM | IC50 | J Med Chem (2006) 49: 3101-3115 [PMID:16722630] |
| ChEMBL | Inhibition of DNA synthesis in IL3 dependent FDC-P1 cells expressing KIT V558D mutant | F | 6.3 | pIC50 | 500 | nM | IC50 | J Med Chem (2006) 49: 3101-3115 [PMID:16722630] |
| ABL proto-oncogene 1, non-receptor tyrosine kinase/Tyrosine-protein kinase ABL in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1862] [GtoPdb: 1923] [UniProtKB: P00519] | ||||||||
| ChEMBL | Inhibition of recombinant Abl | B | 5.89 | pIC50 | 1300 | nM | IC50 | J Med Chem (2006) 49: 3101-3115 [PMID:16722630] |
| fms related receptor tyrosine kinase 3/Tyrosine-protein kinase receptor FLT3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1974] [GtoPdb: 1807] [UniProtKB: P36888] | ||||||||
| ChEMBL | Antiproliferative activity against mouse 32Dcl3 cell line expressing FLT3-ITD | F | 7 | pIC50 | 100 | nM | IC50 | J Med Chem (2006) 49: 3101-3115 [PMID:16722630] |
| ChEMBL | Antiproliferative activity against mouse 32Dcl3 cell line expressing wild-type FLT3 | F | 7 | pIC50 | 100 | nM | IC50 | J Med Chem (2006) 49: 3101-3115 [PMID:16722630] |
| ChEMBL | Inhibition of endogenous FLT3 in EOL1 cells | B | 7.4 | pIC50 | 40 | nM | IC50 | J Med Chem (2006) 49: 3101-3115 [PMID:16722630] |
| GtoPdb | - | - | 7.48 | pIC50 | 33 | nM | IC50 | J Med Chem (2006) 49: 3101-15 [PMID:16722630] |
| ChEMBL | Inhibition of human FLT3 | B | 7.48 | pIC50 | 33 | nM | IC50 | J Med Chem (2006) 49: 3101-3115 [PMID:16722630] |
ChEMBL data shown on this page come from version 34:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
