Flt-3 inhibitor II [Ligand Id: 5971] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL377193 |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| platelet derived growth factor receptor beta/platelet derived growth factor receptor alpha in Human [GtoPdb: 1804, 1803] [UniProtKB: P09619, P16234] | ||||||||
| GtoPdb | - | - | 6.77 | pIC50 | 171 | nM | IC50 | J Med Chem (2006) 49: 3101-15 [PMID:16722630] |
| platelet derived growth factor receptor beta/platelet derived growth factor receptor alpha/Platelet-derived growth factor receptor in Mouse (target type: PROTEIN COMPLEX) [ChEMBL: CHEMBL2096980] [GtoPdb: 1804, 1803] [UniProtKB: P05622, P26618] | ||||||||
| ChEMBL | Inhibition of endogenous PDGFR in Swiss3T3 fibroblasts | B | 6.52 | pIC50 | 300 | nM | IC50 | J Med Chem (2006) 49: 3101-3115 [PMID:16722630] |
| platelet derived growth factor receptor beta/Platelet-derived growth factor receptor beta in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1913] [GtoPdb: 1804] [UniProtKB: P09619] | ||||||||
| ChEMBL | Inhibition of human PDGFR beta | B | 6.77 | pIC50 | 171 | nM | IC50 | J Med Chem (2006) 49: 3101-3115 [PMID:16722630] |
| GtoPdb | - | - | 6.77 | pIC50 | 171 | nM | IC50 | J Med Chem (2006) 49: 3101-15 [PMID:16722630] |
| KIT proto-oncogene, receptor tyrosine kinase/Stem cell growth factor receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1936] [GtoPdb: 1805] [UniProtKB: P10721] | ||||||||
| ChEMBL | Inhibition of DNA synthesis in IL3 dependent FDC-P1 cells expressing wild-type KIT | F | 6.3 | pIC50 | 500 | nM | IC50 | J Med Chem (2006) 49: 3101-3115 [PMID:16722630] |
| ChEMBL | Inhibition of DNA synthesis in IL3 dependent FDC-P1 cells expressing KIT V558D mutant | F | 6.3 | pIC50 | 500 | nM | IC50 | J Med Chem (2006) 49: 3101-3115 [PMID:16722630] |
| ABL proto-oncogene 1, non-receptor tyrosine kinase/Tyrosine-protein kinase ABL in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1862] [GtoPdb: 1923] [UniProtKB: P00519] | ||||||||
| ChEMBL | Inhibition of recombinant Abl | B | 5.89 | pIC50 | 1300 | nM | IC50 | J Med Chem (2006) 49: 3101-3115 [PMID:16722630] |
| fms related receptor tyrosine kinase 3/Tyrosine-protein kinase receptor FLT3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1974] [GtoPdb: 1807] [UniProtKB: P36888] | ||||||||
| ChEMBL | Antiproliferative activity against mouse 32Dcl3 cell line expressing FLT3-ITD | F | 7 | pIC50 | 100 | nM | IC50 | J Med Chem (2006) 49: 3101-3115 [PMID:16722630] |
| ChEMBL | Antiproliferative activity against mouse 32Dcl3 cell line expressing wild-type FLT3 | F | 7 | pIC50 | 100 | nM | IC50 | J Med Chem (2006) 49: 3101-3115 [PMID:16722630] |
| ChEMBL | Inhibition of endogenous FLT3 in EOL1 cells | B | 7.4 | pIC50 | 40 | nM | IC50 | J Med Chem (2006) 49: 3101-3115 [PMID:16722630] |
| GtoPdb | - | - | 7.48 | pIC50 | 33 | nM | IC50 | J Med Chem (2006) 49: 3101-15 [PMID:16722630] |
| ChEMBL | Inhibition of human FLT3 | B | 7.48 | pIC50 | 33 | nM | IC50 | J Med Chem (2006) 49: 3101-3115 [PMID:16722630] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
