EGFR/ErbB-2 inhibitor [Ligand Id: 5964] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL563845
  • epidermal growth factor receptor in Human [GtoPdb: 1797] [UniProtKB: P00533]
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  • erb-b2 receptor tyrosine kinase 2 in Human [GtoPdb: 2019] [UniProtKB: P04626]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
epidermal growth factor receptor in Human [GtoPdb: 1797] [UniProtKB: P00533]
GtoPdb - - 7.7 pIC50 20 nM IC50 Bioorg Med Chem Lett (2001) 11: 1401-5 [PMID:11378364]
erb-b2 receptor tyrosine kinase 2 in Human [GtoPdb: 2019] [UniProtKB: P04626]
GtoPdb - - 7.1 pIC50 79 nM IC50 Bioorg Med Chem Lett (2001) 11: 1401-5 [PMID:11378364]

ChEMBL data shown on this page come from version 31:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, Cibrián-Uhalte E, Davies M, Dedman N, Karlsson A, Magariños MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]