DMBI [Ligand Id: 5958] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL296455
  • Beta-lactamase AmpC in Escherichia coli [ChEMBL: CHEMBL2026] [UniProtKB: P00811]
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  • EPH receptor B2/Ephrin type-B receptor 2 in Human [ChEMBL: CHEMBL3290] [GtoPdb: 1831] [UniProtKB: P29323]
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  • platelet derived growth factor receptor beta/Platelet-derived growth factor receptor beta in Human [ChEMBL: CHEMBL1913] [GtoPdb: 1804] [UniProtKB: P09619]
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  • kinase insert domain receptor/Vascular endothelial growth factor receptor 2 in Mouse [ChEMBL: CHEMBL3337] [GtoPdb: 1813] [UniProtKB: P35918]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
Beta-lactamase AmpC in Escherichia coli (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2026] [UniProtKB: P00811]
ChEMBL Inhibitory activity against beta-lactamase B 5 pIC50 10000 nM IC50 J Med Chem (2002) 45: 1712-1722 [PMID:11931626]
chymotrypsin C/Chymotrypsin C in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2386] [GtoPdb: 2341] [UniProtKB: Q99895]
ChEMBL Inhibitory activity against chymotrypsinogen B 4.52 pIC50 30000 nM IC50 J Med Chem (2002) 45: 1712-1722 [PMID:11931626]
EPH receptor B2/Ephrin type-B receptor 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3290] [GtoPdb: 1831] [UniProtKB: P29323]
ChEMBL Equilibrium binding constant for EPH receptor B2 B 4.71 pKd 19500 nM Kd J Med Chem (2005) 48: 3221-3230 [PMID:15857128]
ChEMBL Inhibition of EPH receptor B2 using ELISA B 4.56 pIC50 27500 nM IC50 J Med Chem (2005) 48: 3221-3230 [PMID:15857128]
platelet derived growth factor receptor beta/Platelet-derived growth factor receptor beta in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1913] [GtoPdb: 1804] [UniProtKB: P09619]
ChEMBL Inhibition Assay: Inhibition of various kinase enzyme. B 5.43 pIC50 3750 nM IC50 US-9422297-B2. Tricyclic compounds having cytostatic and/or cytotoxic activity and methods of use thereof (2016)
kinase insert domain receptor/Vascular endothelial growth factor receptor 2 in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3337] [GtoPdb: 1813] [UniProtKB: P35918]
ChEMBL Inhibitory activity against vascular endothelial growth factor receptor 2 (FLK1) B 6.1 pIC50 794.33 nM IC50 J Med Chem (2000) 43: 3020-3032 [PMID:10956210]
GtoPdb - - 6.1 pIC50 794 nM IC50 J Med Chem (2000) 43: 3020-32 [PMID:10956210]

ChEMBL data shown on this page come from version 34:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]