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ChEMBL ligand: CHEMBL296455 |
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DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
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Beta-lactamase AmpC in Escherichia coli (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2026] [UniProtKB: P00811] | ||||||||
ChEMBL | Inhibitory activity against beta-lactamase | B | 5 | pIC50 | 10000 | nM | IC50 | J Med Chem (2002) 45: 1712-1722 [PMID:11931626] |
chymotrypsin C/Chymotrypsin C in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2386] [GtoPdb: 2341] [UniProtKB: Q99895] | ||||||||
ChEMBL | Inhibitory activity against chymotrypsinogen | B | 4.52 | pIC50 | 30000 | nM | IC50 | J Med Chem (2002) 45: 1712-1722 [PMID:11931626] |
EPH receptor B2/Ephrin type-B receptor 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3290] [GtoPdb: 1831] [UniProtKB: P29323] | ||||||||
ChEMBL | Equilibrium binding constant for EPH receptor B2 | B | 4.71 | pKd | 19500 | nM | Kd | J Med Chem (2005) 48: 3221-3230 [PMID:15857128] |
ChEMBL | Inhibition of EPH receptor B2 using ELISA | B | 4.56 | pIC50 | 27500 | nM | IC50 | J Med Chem (2005) 48: 3221-3230 [PMID:15857128] |
platelet derived growth factor receptor beta/Platelet-derived growth factor receptor beta in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1913] [GtoPdb: 1804] [UniProtKB: P09619] | ||||||||
ChEMBL | Inhibition Assay: Inhibition of various kinase enzyme. | B | 5.43 | pIC50 | 3750 | nM | IC50 | US-9422297-B2. Tricyclic compounds having cytostatic and/or cytotoxic activity and methods of use thereof (2016) |
kinase insert domain receptor/Vascular endothelial growth factor receptor 2 in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3337] [GtoPdb: 1813] [UniProtKB: P35918] | ||||||||
ChEMBL | Inhibitory activity against vascular endothelial growth factor receptor 2 (FLK1) | B | 6.1 | pIC50 | 794.33 | nM | IC50 | J Med Chem (2000) 43: 3020-3032 [PMID:10956210] |
GtoPdb | - | - | 6.1 | pIC50 | 794 | nM | IC50 | J Med Chem (2000) 43: 3020-32 [PMID:10956210] |
ChEMBL data shown on this page come from version 34:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]