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ChEMBL ligand: CHEMBL266487 (Ro-31-6233) |
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DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
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calcium/calmodulin-dependent protein kinase II delta subunit/CaM kinase II delta in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2801] [GtoPdb: 1558] [UniProtKB: Q13557] | ||||||||
ChEMBL | Inhibition of CaMK2delta | B | 5.92 | pIC50 | 1190 | nM | IC50 | Bioorg Med Chem Lett (2008) 18: 2395-2398 [PMID:18334295] |
protein kinase, cAMP-dependent, catalytic, alpha subunit/cAMP-dependent protein kinase alpha-catalytic subunit in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3390] [GtoPdb: 1476] [UniProtKB: P27791] | ||||||||
ChEMBL | Inhibition of rat brain protein kinase A(PKA) in 10%DMSO | B | 4.93 | pIC50 | 11800 | nM | IC50 | J Med Chem (1992) 35: 177-184 [PMID:1732526] |
ChEMBL | Inhibition of rat brain protein kinase A(PKA) in 1%DMSO | B | 5.51 | pIC50 | 3100 | nM | IC50 | J Med Chem (1992) 35: 177-184 [PMID:1732526] |
cyclin dependent kinase 1/Cyclin-dependent kinase 1/cyclin B in Human (target type: PROTEIN COMPLEX) [ChEMBL: CHEMBL2094127] [GtoPdb: 1961] [UniProtKB: O95067, P06493, P14635, Q8WWL7] | ||||||||
ChEMBL | Inhibitory concentration was determined by measuring phosphorylation of H1 histone using active human Cell division cycle 2-cyclin B complex | B | 4.74 | pIC50 | 18000 | nM | IC50 | Bioorg Med Chem Lett (1998) 8: 1019-1022 [PMID:9871700] |
cyclin dependent kinase 2/Cyclin-dependent kinase 2/cyclin E in Human (target type: PROTEIN COMPLEX) [ChEMBL: CHEMBL2094126] [GtoPdb: 1973] [UniProtKB: O96020, P24864, P24941] | ||||||||
ChEMBL | Inhibitory activity against Cyclin E-cyclin-dependent kinase 2 by measuring phosphorylation of RbING substrate | B | 4.93 | pIC50 | 11690 | nM | IC50 | Bioorg Med Chem Lett (2003) 13: 3841-3846 [PMID:14552792] |
cyclin dependent kinase 4/Cyclin-dependent kinase 4/cyclin D1 in Human (target type: PROTEIN COMPLEX) [ChEMBL: CHEMBL1907601] [GtoPdb: 1976] [UniProtKB: P11802, P24385] | ||||||||
ChEMBL | Inhibitory activity against Cyclin D1-cyclin-dependent kinase 4 by measuring phosphorylation of RbING substrate | B | 5.24 | pIC50 | 5810 | nM | IC50 | Bioorg Med Chem Lett (2003) 13: 3841-3846 [PMID:14552792] |
epidermal growth factor receptor/Epidermal growth factor receptor erbB1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL203] [GtoPdb: 1797] [UniProtKB: P00533] | ||||||||
ChEMBL | Inhibitory activity against recombinant tyrosine kinase EGF-R (EGF-R ICD) | B | 4.3 | pIC50 | >50000 | nM | IC50 | J Med Chem (1994) 37: 1015-1027 [PMID:8151612] |
sirtuin 2/NAD-dependent deacetylase sirtuin 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4462] [GtoPdb: 2708] [UniProtKB: Q8IXJ6] | ||||||||
ChEMBL | Inhibition of human recombinant SIRT2 | B | 5.33 | pIC50 | 4700 | nM | IC50 | J Med Chem (2006) 49: 7307-7316 [PMID:17149860] |
protein kinase C alpha/Protein kinase C alpha in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL299] [GtoPdb: 1482] [UniProtKB: P17252] | ||||||||
ChEMBL | Inhibitory concentration against recombinant human Protein kinase C alpha | B | 5.8 | pIC50 | 1599 | nM | IC50 | Bioorg Med Chem Lett (2004) 14: 5171-5174 [PMID:15380221] |
protein kinase C beta/Protein kinase C beta in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3045] [GtoPdb: 1483] [UniProtKB: P05771] | ||||||||
ChEMBL | Inhibitory concentration against recombinant human Protein kinase C beta 1 | B | 6.52 | pIC50 | 304 | nM | IC50 | Bioorg Med Chem Lett (2004) 14: 5171-5174 [PMID:15380221] |
GtoPdb | PKCβ2 isoform | - | 6.67 | pIC50 | 212 | nM | IC50 | Bioorg Med Chem Lett (2004) 14: 5171-4 [PMID:15380221] |
ChEMBL | Inhibitory concentration against recombinant human Protein kinase C beta 2 | B | 6.67 | pIC50 | 212 | nM | IC50 | Bioorg Med Chem Lett (2004) 14: 5171-5174 [PMID:15380221] |
ChEMBL | Inhibition of PKCbeta2 (unknown origin) | B | 7.8 | pIC50 | 16 | nM | IC50 | J Med Chem (2022) 65: 893-921 [PMID:33539089] |
protein kinase C epsilon/Protein kinase C epsilon in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3582] [GtoPdb: 1486] [UniProtKB: Q02156] | ||||||||
ChEMBL | Inhibitory concentration against recombinant human Protein kinase C epsilon | B | 5.12 | pIC50 | 7516 | nM | IC50 | Bioorg Med Chem Lett (2004) 14: 5171-5174 [PMID:15380221] |
protein kinase C gamma/Protein kinase C gamma in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3604] [GtoPdb: 1484] [UniProtKB: P63319] | ||||||||
ChEMBL | Inhibition of rat brain protein kinase C (PKC) with ATP and histone as substrates | B | 6.26 | pIC50 | 550 | nM | IC50 | J Med Chem (1992) 35: 177-184 [PMID:1732526] |
Pim-1 proto-oncogene, serine/threonine kinase/Serine/threonine-protein kinase PIM1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2147] [GtoPdb: 2158] [UniProtKB: P11309] | ||||||||
ChEMBL | Binding affinity to non phosphorylated PIM1 | B | 7.57 | pKd | 27 | nM | Kd | J Med Chem (2005) 48: 7604-7614 [PMID:16302800] |
ChEMBL data shown on this page come from version 34:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]