alsterpaullone [Ligand Id: 5925] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL50894
  • cyclin dependent kinase 1 in Human [GtoPdb: 1961] [UniProtKB: P06493]
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  • glycogen synthase kinase 3 beta in Human [GtoPdb: 2030] [UniProtKB: P49841]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
cyclin dependent kinase 1 in Human [GtoPdb: 1961] [UniProtKB: P06493]
GtoPdb CDK1 in association with cyclin B - 7.46 pIC50 35 nM IC50 Eur J Biochem (2000) 267: 5983-94 [PMID:10998059]
glycogen synthase kinase 3 beta in Human [GtoPdb: 2030] [UniProtKB: P49841]
GtoPdb - - 8.4 pIC50 4 nM IC50 Eur J Biochem (2000) 267: 5983-94 [PMID:10998059]

ChEMBL data shown on this page come from version 36:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]