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ChEMBL ligand: CHEMBL580 (Abbloraz, Ativan, Loraz, Lorazepam, Lorazepam civ, Lorazepam intensol, Lorazepam preservative free, Loreev xr, NSC-289758, Temesta, WY-4036) |
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DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
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fatty acid binding protein 1/Fatty acid-binding protein, liver in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5738] [GtoPdb: 2531] [UniProtKB: P02692] | ||||||||
ChEMBL | Displacement of 1-anilinonaphthalene-8-sulphonic acid from rat recombinant L-FABP high binding affinity site expressed in Escherichia coli BL21 by competitive fluorescence displacement assay | B | 4.89 | pKi | 12900 | nM | Ki | J Med Chem (2008) 51: 3755-3764 [PMID:18533710] |
α1B-adrenoceptor in Rat [GtoPdb: 23] [UniProtKB: P15823] | ||||||||
GtoPdb | - | - | 3.8 | pKi | 170000 | nM | Ki | J Pharmacol Exp Ther (1999) 291: 1164-71 [PMID:10565838] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]