eprosartan [Ligand Id: 588] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL813 (Eprosartan, SK-108566, SK&F 108566, SK&F-108566, Teveten) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| AT2 receptor/Angiotensin II type 2 (AT-2) receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL257] [GtoPdb: 35] [UniProtKB: P35351] | ||||||||
| ChEMBL | In vitro inhibition of [125I]AII specific binding towards Angiotensin II receptor in rat mesenteric membranes. | B | 9 | pIC50 | 1 | nM | IC50 | J Med Chem (1991) 34: 1514-1517 [PMID:2016730] |
| AT1 receptor/Type-1 angiotensin II receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL227] [GtoPdb: 34] [UniProtKB: P30556] | ||||||||
| ChEMBL | Tested for Angiotensin II receptor, type 1 affinity in the presence of 0.25% bovine serum albumin (BSA) | B | 8.14 | pIC50 | 7.3 | nM | IC50 | Bioorg Med Chem Lett (1994) 4: 23-28 |
| ChEMBL | Tested for Angiotensin II receptor, type 1 affinity in the absence of bovine serum albumin (BSA) | B | 8.7 | pIC50 | 2 | nM | IC50 | Bioorg Med Chem Lett (1994) 4: 23-28 |
| GtoPdb | - | - | 8.8 | pIC50 | 1.58 | nM | IC50 | J Pharmacol Exp Ther (1992) 260: 175-81 [PMID:1309870] |
| AT1 receptor in Human [GtoPdb: 34] [UniProtKB: P30556] | ||||||||
| GtoPdb | - | - | 8.8 | pIC50 | 1.58 | nM | IC50 | J Pharmacol Exp Ther (1992) 260: 175-81 [PMID:1309870] |
| AT1 receptor/Type-1B angiotensin II receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL263] [GtoPdb: 34] [UniProtKB: P29089] | ||||||||
| ChEMBL | Tested for inhibition of [125I]- AII specific binding to rat mesenteric arteries, expressed as IC50 | B | 9 | pIC50 | 1 | nM | IC50 | Bioorg Med Chem Lett (1994) 4: 23-28 |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
