Zn2+ [Ligand Id: 566] activity data from GtoPdb

Click here for a description of the charts and data table

Please tell us if you are using this feature and what you think!

  • β2-adrenoceptor in Human [GtoPdb: 29] [UniProtKB: P07550]
There should be some charts here, you may need to enable JavaScript!
  • GPR83 in Mouse [GtoPdb: 119] [UniProtKB: P30731]
There should be some charts here, you may need to enable JavaScript!
  • glycine receptor α1 subunit in Human [GtoPdb: 423] [UniProtKB: P23415]
There should be some charts here, you may need to enable JavaScript!
  • glycine receptor α2 subunit in Human [GtoPdb: 424] [UniProtKB: P23416]
There should be some charts here, you may need to enable JavaScript!
  • glycine receptor α3 subunit in Human [GtoPdb: 425] [UniProtKB: O75311]
There should be some charts here, you may need to enable JavaScript!
  • glycine receptor β subunit in Human [GtoPdb: 427] [UniProtKB: P48167]
There should be some charts here, you may need to enable JavaScript!
  • TRPA1 in Mouse [GtoPdb: 485] [UniProtKB: Q8BLA8]
There should be some charts here, you may need to enable JavaScript!
  • TRPM1 in Human [GtoPdb: 493] [UniProtKB: Q7Z4N2]
There should be some charts here, you may need to enable JavaScript!
  • TRPM2 in Human [GtoPdb: 494] [UniProtKB: O94759]
There should be some charts here, you may need to enable JavaScript!
  • ZAC in Human [GtoPdb: 587] [UniProtKB: Q401N2]
There should be some charts here, you may need to enable JavaScript!
  • ASIC1 in Human [GtoPdb: 684] [UniProtKB: P78348]
There should be some charts here, you may need to enable JavaScript!
  • ASIC3 in Human [GtoPdb: 686] [UniProtKB: Q9UHC3]
There should be some charts here, you may need to enable JavaScript!
  • ClC-4 in Human [GtoPdb: 703] [UniProtKB: P51793]
There should be some charts here, you may need to enable JavaScript!
  • Maxi Cl- in Human [GtoPdb: 709]
There should be some charts here, you may need to enable JavaScript!
  • Hv1 in Human [GtoPdb: 746] [UniProtKB: Q96D96]
There should be some charts here, you may need to enable JavaScript!
DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
β2-adrenoceptor in Human [GtoPdb: 29] [UniProtKB: P07550]
GtoPdb - - 3.3 pKi - - - J Biol Chem (2003) 278: 352-6 [PMID:12409304];
Mol Pharmacol (2002) 61: 65-72 [PMID:11752207]
GtoPdb - - 5.3 pKi - - - J Biol Chem (2003) 278: 352-6 [PMID:12409304];
Mol Pharmacol (2002) 61: 65-72 [PMID:11752207]
GPR83 in Mouse [GtoPdb: 119] [UniProtKB: P30731]
GtoPdb - - 5 pEC50 10200 nM EC50 PLoS ONE (2013) 8: e53347 [PMID:23335960]
glycine receptor α1 subunit in Human [GtoPdb: 423] [UniProtKB: P23415]
GtoPdb - - 4.8 pIC50 15000 nM IC50
GtoPdb - - 7.4 pEC50 37 nM EC50
glycine receptor α2 subunit in Human [GtoPdb: 424] [UniProtKB: P23416]
GtoPdb - - 3.4 pIC50 360000 nM IC50
GtoPdb - - 6.3 pEC50 540 nM EC50
glycine receptor α3 subunit in Human [GtoPdb: 425] [UniProtKB: O75311]
GtoPdb - - 3.8 pIC50 150000 nM IC50
glycine receptor β subunit in Human [GtoPdb: 427] [UniProtKB: P48167]
GtoPdb - - 3.7 pIC50 180000 nM IC50
GtoPdb - - 4.9 pIC50 13000 nM IC50
TRPA1 in Mouse [GtoPdb: 485] [UniProtKB: Q8BLA8]
GtoPdb Calcium imaging - 2.3 pEC50 - - - Nat Chem Biol (2009) 5: 183-90 [PMID:19202543];
Proc Natl Acad Sci USA (2009) 106: 8374-9 [PMID:19416844]
TRPM1 in Human [GtoPdb: 493] [UniProtKB: Q7Z4N2]
GtoPdb - - 6 pIC50 1000 nM IC50
TRPM2 in Human [GtoPdb: 494] [UniProtKB: O94759]
GtoPdb - - 6 pIC50 1000 nM IC50
ZAC in Human [GtoPdb: 587] [UniProtKB: Q401N2]
GtoPdb - - 3.7 pEC50 - - EC50 J Biol Chem (2003) 278: 712-7 [PMID:12381728];
Biochem Pharmacol (2016) 103: 109-17 [PMID:26872532]
ASIC1 in Human [GtoPdb: 684] [UniProtKB: P78348]
GtoPdb - - 8.2 pIC50 ~7 nM IC50 J Neurosci (2004) 24: 8678-89 [PMID:15470133]
ASIC3 in Human [GtoPdb: 686] [UniProtKB: Q9UHC3]
GtoPdb - - 4.2 pIC50 61000 nM IC50 Neuroscience (2010) 169: 574-83 [PMID:20580786]
ClC-4 in Human [GtoPdb: 703] [UniProtKB: P51793]
GtoPdb - - 4.3 pIC50 50000 nM IC50 Biophys J (2008) 95: 4668-75 [PMID:18658230]
Maxi Cl- in Human [GtoPdb: 709]
GtoPdb - - 4.3 pIC50 50000 nM IC50 Biophys J (2008) 95: 4668-75 [PMID:18658230]
Hv1 in Human [GtoPdb: 746] [UniProtKB: Q96D96]
GtoPdb - - 6.3 pIC50 ~500 nM IC50

Our curators have not yet identified this ligand in ChEMBL, but you may find additional data by searching on the ChEMBL site using the ligand's name or structure.