KF26777 [Ligand Id: 5618] activity data from GtoPdb and ChEMBL
Click here for a description of the charts and data table
Please tell us if you are using this feature and what you think!
| ChEMBL ligand: CHEMBL2181965 |
|---|
|
There should be some charts here, you may need to enable JavaScript!
|
|
There should be some charts here, you may need to enable JavaScript!
|
|
There should be some charts here, you may need to enable JavaScript!
|
|
There should be some charts here, you may need to enable JavaScript!
|
| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| A1 receptor/Adenosine receptor A1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL226] [GtoPdb: 18] [UniProtKB: P30542] | ||||||||
| GtoPdb | - | - | 5.74 | pKi | 1800 | nM | Ki | Eur J Pharmacol (2002) 444: 133-41 [PMID:12063073] |
| ChEMBL | Displacement of [3H]CCPA from human recombinant adenosine A1 receptor expressed in CHO cells after 60 mins by gamma counter | B | 5.74 | pKi | 1800 | nM | Ki | J Med Chem (2012) 55: 5676-5703 [PMID:22468757] |
| A2A receptor/Adenosine receptor A2a in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL251] [GtoPdb: 19] [UniProtKB: P29274] | ||||||||
| ChEMBL | Displacement of [3H]CGS21680 from human recombinant adenosine A2A receptor expressed in CHO cells after 60 mins by gamma counter | B | 6.33 | pKi | 470 | nM | Ki | J Med Chem (2012) 55: 5676-5703 [PMID:22468757] |
| GtoPdb | - | - | 6.33 | pKi | 470 | nM | Ki | Eur J Pharmacol (2002) 444: 133-41 [PMID:12063073] |
| A3 receptor/Adenosine receptor A3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL256] [GtoPdb: 21] [UniProtKB: P0DMS8] | ||||||||
| ChEMBL | Displacement of [125I]I-AB-MECA from human recombinant adenosine A3 receptor expressed in CHO cells after 60 mins by gamma counter | B | 9.7 | pKi | 0.2 | nM | Ki | J Med Chem (2012) 55: 5676-5703 [PMID:22468757] |
| GtoPdb | - | - | 9.7 | pKi | 0.2 | nM | Ki | Eur J Pharmacol (2002) 444: 133-41 [PMID:12063073] |
| ChEMBL | Antagonist activity at human adenosine A3 receptor expressed in CHO cells by [S35]GTPgammaS binding assay | F | 6.57 | pIC50 | 270 | nM | IC50 | J Med Chem (2012) 55: 5676-5703 [PMID:22468757] |
| A2B receptor in Human [GtoPdb: 20] [UniProtKB: P29275] | ||||||||
| GtoPdb | - | - | 6.21 | pKi | 620 | nM | Ki | Eur J Pharmacol (2002) 444: 133-41 [PMID:12063073] |
ChEMBL data shown on this page come from version 36:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
