ChEMBL ligand: CHEMBL240624 (MK-3814, Preladenant, Sch-420814, SCH 420814, SCH-420814)
A1 receptor/Adenosine A1 receptor in Human [ChEMBL: CHEMBL226] [GtoPdb: 18] [UniProtKB: P30542] A1 receptor/Adenosine A1 receptor in Rat [ChEMBL: CHEMBL318] [GtoPdb: 18] [UniProtKB: P25099] There should be some charts here, you may need to enable JavaScript!
A2A receptor/Adenosine A2a receptor in Human [ChEMBL: CHEMBL251] [GtoPdb: 19] [UniProtKB: P29274] A2A receptor/Adenosine A2a receptor in Rat [ChEMBL: CHEMBL302] [GtoPdb: 19] [UniProtKB: P30543] There should be some charts here, you may need to enable JavaScript!
A2B receptor/Adenosine A2b receptor in Human [ChEMBL: CHEMBL255] [GtoPdb: 20] [UniProtKB: P29275] There should be some charts here, you may need to enable JavaScript!
A3 receptor/Adenosine A3 receptor in Human [ChEMBL: CHEMBL256] [GtoPdb: 21] [UniProtKB: P0DMS8] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
A1 receptor/Adenosine A1 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL226] [GtoPdb: 18] [UniProtKB: P30542]
ChEMBL	Inhibition of human recombinant adenosine A1 receptor	B	5.83	pKi	1474	nM	Ki	J Med Chem (2014) 57: 3623-3650 [PMID:24164628]
GtoPdb	-	-	6	pKi	>1000	nM	Ki	Recent Pat CNS Drug Discov (2007) 2: 1-21 [PMID:18221214]
ChEMBL	Binding affinity to human adenosine A1 receptor	B	6	pKi	>1000	nM	Ki	Bioorg Med Chem Lett (2007) 17: 1376-1380 [PMID:17236762]
ChEMBL	Displacement of [3H]DPCPX from human adenosine A1 receptor expressed in CHO cells by liquid scintillation counting	B	6	pKi	>1000	nM	Ki	Bioorg Med Chem Lett (2010) 20: 5241-5244 [PMID:20659802]
ChEMBL	Inhibition of human recombinant adenosine A1 receptor	B	6	pKi	>996	nM	Ki	J Med Chem (2014) 57: 3623-3650 [PMID:24164628]
ChEMBL	Displacement of [3H]CCPA from human recombinant adenosine A1 receptor expressed in CHO cells after 90 mins by liquid scintillation counting analysis	B	6.53	pKi	295	nM	Ki	J Med Chem (2013) 56: 4580-4596 [PMID:23631427]
ChEMBL	Displacement of [3H]CCPA from human recombinant adenosine A1 receptor expressed in CHO cells by liquid scintillation counting analysis	B	6.53	pKi	295	nM	Ki	J Med Chem (2021) 64: 8246-8262 [PMID:34107215]
A1 receptor/Adenosine A1 receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL318] [GtoPdb: 18] [UniProtKB: P25099]
ChEMBL	Displacement of [3H]CCPA from adenosine A1 receptor in rat brain cortical membranes after 90 mins by liquid scintillation counting analysis	B	7.16	pKi	68.7	nM	Ki	J Med Chem (2013) 56: 4580-4596 [PMID:23631427]
A2A receptor/Adenosine A2a receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL251] [GtoPdb: 19] [UniProtKB: P29274]
ChEMBL	Displacement of [3H]ZM241385 from stabilized human adenosine receptor A2a expressed in HEK293 cells followed by receptor capturing on Biocore chips by SPR method	B	9.5	pKd	0.32	nM	Kd	J Med Chem (2011) 54: 4312-4323 [PMID:21661720]
ChEMBL	Displacement of [3H]ZM241385 from human adenosine A2A receptor expressed in buculovirus system by liquid scintillation counting	B	8.3	pKi	5	nM	Ki	Bioorg Med Chem Lett (2010) 20: 5241-5244 [PMID:20659802]
ChEMBL	Displacement of [3H]-ZM241385 from human adenosine A2A receptor expressed in high five cells after 30 mins by scintillation counting	B	8.3	pKi	5	nM	Ki	J Med Chem (2011) 54: 751-764 [PMID:21210664]
ChEMBL	Displacement of [3H]ZM241385 from stabilized human adenosine receptor A2a expressed in HEK293 cells followed by receptor capturing on Biocore chips by SPR method	B	8.8	pKi	1.58	nM	Ki	J Med Chem (2011) 54: 4312-4323 [PMID:21661720]
ChEMBL	Antagonist activity at human adenosine A2A receptor	B	8.96	pKi	1.1	nM	Ki	Medchemcomm (2019) 10: 1094-1108 [PMID:31391881]
ChEMBL	Inhibition of human recombinant adenosine receptor A2a	F	8.96	pKi	1.1	nM	Ki	J Med Chem (2014) 57: 3623-3650 [PMID:24164628]
ChEMBL	Displacement of [3H]SCH58261 from human adenosine 2A receptor expressed in HEK293 cell membranes incubated for 1.5 hrs by radioligand competition binding assay	B	8.96	pKi	1.1	nM	Ki	J Med Chem (2020) 63: 12196-12212 [PMID:32667814]
ChEMBL	Binding affinity to human adenosine A2A receptor	B	8.96	pKi	1.1	nM	Ki	Bioorg Med Chem Lett (2007) 17: 1376-1380 [PMID:17236762]
ChEMBL	Displacement of [3H]-ZM241385 from human adenosine A2A receptor expressed in HEK293 cells	B	9	pKi	1	nM	Ki	Bioorg Med Chem Lett (2014) 24: 152-155 [PMID:24332624]
GtoPdb	-	-	9.05	pKi	0.9	nM	Ki	Recent Pat CNS Drug Discov (2007) 2: 1-21 [PMID:18221214]
ChEMBL	Displacement of [3H]MSX2 from human recombinant adenosine A2A receptor expressed in CHO cells after 30 mins by liquid scintillation counting analysis	B	9.05	pKi	0.88	nM	Ki	J Med Chem (2013) 56: 4580-4596 [PMID:23631427]
ChEMBL	Displacement of [3H]MSX-2 from human recombinant adenosine A2A receptor expressed in CHO cells by liquid scintillation counting analysis	B	9.06	pKi	0.88	nM	Ki	J Med Chem (2021) 64: 8246-8262 [PMID:34107215]
ChEMBL	Inhibition of human recombinant adenosine receptor A2a	F	9.22	pKi	0.6	nM	Ki	J Med Chem (2014) 57: 3623-3650 [PMID:24164628]
ChEMBL	Antagonist activity at adenosine A2A receptor (unknown origin)	F	9.3	pKi	0.5	nM	Ki	Eur J Med Chem (2018) 144: 151-163 [PMID:29268131]
A2A receptor/Adenosine A2a receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL302] [GtoPdb: 19] [UniProtKB: P30543]
ChEMBL	Binding affinity to rat adenosine A2A receptor	B	8.6	pKi	2.5	nM	Ki	Bioorg Med Chem Lett (2007) 17: 1376-1380 [PMID:17236762]
ChEMBL	Displacement of [3H]MSX2 from adenosine A2A receptor in rat brain striatal membranes after 30 mins by liquid scintillation counting analysis	B	9.18	pKi	0.66	nM	Ki	J Med Chem (2013) 56: 4580-4596 [PMID:23631427]
A2B receptor/Adenosine A2b receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL255] [GtoPdb: 20] [UniProtKB: P29275]
ChEMBL	Binding affinity to human adenosine A2B receptor	B	5.77	pKi	>1700	nM	Ki	Bioorg Med Chem Lett (2007) 17: 1376-1380 [PMID:17236762]
ChEMBL	Inhibition of human recombinant adenosine receptor A2b	B	5.77	pKi	>1700	nM	Ki	J Med Chem (2014) 57: 3623-3650 [PMID:24164628]
GtoPdb	-	-	6	pKi	>1000	nM	Ki	Recent Pat CNS Drug Discov (2007) 2: 1-21 [PMID:18221214]
ChEMBL	Displacement of [3H]PSB-603 from human recombinant adenosine A2B receptor expressed in CHO cells after 75 mins by liquid scintillation counting analysis	B	6	pKi	>1000	nM	Ki	J Med Chem (2013) 56: 4580-4596 [PMID:23631427]
ChEMBL	Displacement of [3H]PSB-603 from human recombinant adenosine A2B receptor expressed in CHO cells by liquid scintillation counting analysis	B	6	pKi	>1000	nM	Ki	J Med Chem (2021) 64: 8246-8262 [PMID:34107215]
A3 receptor/Adenosine A3 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL256] [GtoPdb: 21] [UniProtKB: P0DMS8]
GtoPdb	-	-	6	pKi	>1000	nM	Ki	Recent Pat CNS Drug Discov (2007) 2: 1-21 [PMID:18221214]
ChEMBL	Binding affinity to human adenosine A3 receptor	B	6	pKi	>1000	nM	Ki	Bioorg Med Chem Lett (2007) 17: 1376-1380 [PMID:17236762]
ChEMBL	Displacement of [3H]PSB-11 from human recombinant adenosine A3 receptor expressed in CHO cells after 60 mins by liquid scintillation counting analysis	B	6	pKi	>1000	nM	Ki	J Med Chem (2013) 56: 4580-4596 [PMID:23631427]
ChEMBL	Inhibition of human recombinant adenosine A3 receptor	B	6	pKi	>1000	nM	Ki	J Med Chem (2014) 57: 3623-3650 [PMID:24164628]
ChEMBL	Displacement of [3H]PSB-11 from human recombinant adenosine A3 receptor expressed in CHO cells by liquid scintillation counting analysis	B	6	pKi	>1000	nM	Ki	J Med Chem (2021) 64: 8246-8262 [PMID:34107215]

ChEMBL data shown on this page come from version 33:

Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]