CPFPX [Ligand Id: 5603] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL2311146
  • A1 receptor/Adenosine receptor A1 in Human [ChEMBL: CHEMBL226] [GtoPdb: 18] [UniProtKB: P30542]
  • Adenosine receptor A1 in Bovine [ChEMBL: CHEMBL4975] [UniProtKB: P28190]
  • A1 receptor/Adenosine receptor A1 in Rat [ChEMBL: CHEMBL318] [GtoPdb: 18] [UniProtKB: P25099]
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  • A2A receptor in Human [GtoPdb: 19] [UniProtKB: P29274]
  • A2A receptor/Adenosine receptor A2a in Rat [ChEMBL: CHEMBL302] [GtoPdb: 19] [UniProtKB: P30543]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
A1 receptor/Adenosine receptor A1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL226] [GtoPdb: 18] [UniProtKB: P30542]
ChEMBL In vitro binding affinity for porcine Adenosine A1 receptor B 8.86 pKd 1.37 nM Kd J Med Chem (2002) 45: 5150-5156 [PMID:12408725]
ChEMBL In vitro binding affinity for human Adenosine A1 receptor expressed in CHO-K1 cells B 8.9 pKd 1.26 nM Kd J Med Chem (2002) 45: 5150-5156 [PMID:12408725]
GtoPdb - - 8.9 pKi 1.26 nM Ki J Med Chem (2002) 45: 5150-6 [PMID:12408725]
Adenosine receptor A1 in Bovine (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4975] [UniProtKB: P28190]
ChEMBL In vitro binding affinity for Adenosine A1 receptor of bovine cortex B 9.74 pKi 0.18 nM Ki J Med Chem (2002) 45: 5150-5156 [PMID:12408725]
A1 receptor/Adenosine receptor A1 in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL318] [GtoPdb: 18] [UniProtKB: P25099]
ChEMBL In vitro binding affinity at rat Adenosine A1 receptor B 9.2 pKd 0.63 nM Kd J Med Chem (2002) 45: 5150-5156 [PMID:12408725]
GtoPdb - - 9.2 pKi 0.63 nM Ki J Med Chem (2002) 45: 5150-6 [PMID:12408725]
A2A receptor in Human [GtoPdb: 19] [UniProtKB: P29274]
GtoPdb - - 6.03 pKi 940 nM Ki J Med Chem (2002) 45: 5150-6 [PMID:12408725]
A2A receptor/Adenosine receptor A2a in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL302] [GtoPdb: 19] [UniProtKB: P30543]
GtoPdb - - 6.09 pKi 812 nM Ki J Med Chem (2002) 45: 5150-6 [PMID:12408725]
ChEMBL In vitro binding affinity at Adenosine A2A receptor of rat cortex B 6.09 pKi 812 nM Ki J Med Chem (2002) 45: 5150-5156 [PMID:12408725]

ChEMBL data shown on this page come from version 36:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]