terguride [Ligand Id: 56] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL73151 (Teluron, Terguride)
  • D1 receptor/Dopamine D1 receptor in Rat [ChEMBL: CHEMBL265] [GtoPdb: 214] [UniProtKB: P18901]
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  • D2 receptor in Human [GtoPdb: 215] [UniProtKB: P14416]
  • D2 receptor/Dopamine D2 receptor in Rat [ChEMBL: CHEMBL339] [GtoPdb: 215] [UniProtKB: P61169]
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  • 5-HT1A receptor in Human [GtoPdb: 1] [UniProtKB: P08908]
  • 5-HT1A receptor/Serotonin 1a (5-HT1a) receptor in Rat [ChEMBL: CHEMBL273] [GtoPdb: 1] [UniProtKB: P19327]
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  • 5-HT1B receptor in Human [GtoPdb: 2] [UniProtKB: P28222]
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  • 5-HT1D receptor in Human [GtoPdb: 3] [UniProtKB: P28221]
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  • 5-HT2A receptor in Human [GtoPdb: 6] [UniProtKB: P28223]
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  • 5-HT2B receptor in Human [GtoPdb: 7] [UniProtKB: P41595]
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  • 5-HT2C receptor in Human [GtoPdb: 8] [UniProtKB: P28335]
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  • α1A-adrenoceptor in Human [GtoPdb: 22] [UniProtKB: P35348]
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  • α2A-adrenoceptor in Human [GtoPdb: 25] [UniProtKB: P08913]
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  • α2B-adrenoceptor in Human [GtoPdb: 26] [UniProtKB: P18089]
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  • α2C-adrenoceptor in Human [GtoPdb: 27] [UniProtKB: P18825]
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  • D3 receptor in Human [GtoPdb: 216] [UniProtKB: P35462]
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  • D4 receptor in Human [GtoPdb: 217] [UniProtKB: P21917]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
D1 receptor/Dopamine D1 receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL265] [GtoPdb: 214] [UniProtKB: P18901]
ChEMBL In vitro binding activity against Dopamine receptor D1 from homogenized rat brain, using [3H]SCH-23390 as the radioligand B 7.16 pIC50 69 nM IC50 J Med Chem (1989) 32: 2273-2276 [PMID:2571729]
D2 receptor in Human [GtoPdb: 215] [UniProtKB: P14416]
GtoPdb - - 8.9 pKi - - - J Pharmacol Exp Ther (2002) 303: 791-804 [PMID:12388666]
GtoPdb - - 9.1 pKi - - - J Pharmacol Exp Ther (2002) 303: 791-804 [PMID:12388666]
D2 receptor/Dopamine D2 receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL339] [GtoPdb: 215] [UniProtKB: P61169]
ChEMBL In vitro binding activity against dopamine receptor D2 from homogenized rat brain, using [3H]spiperone as the radioligand B 8.4 pIC50 4 nM IC50 J Med Chem (1989) 32: 2273-2276 [PMID:2571729]
5-HT1A receptor in Human [GtoPdb: 1] [UniProtKB: P08908]
GtoPdb - - 8.5 pKi - - - J Pharmacol Exp Ther (2002) 303: 791-804 [PMID:12388666]
5-HT1A receptor/Serotonin 1a (5-HT1a) receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL273] [GtoPdb: 1] [UniProtKB: P19327]
ChEMBL In vitro binding activity against 5-hydroxytryptamine 1A receptor from homogenized rat brain, using [3H]-8-OH-DPAT as the radioligand B 7.6 pIC50 25 nM IC50 J Med Chem (1989) 32: 2273-2276 [PMID:2571729]
5-HT1B receptor in Human [GtoPdb: 2] [UniProtKB: P28222]
GtoPdb - - 6.6 pKi - - - J Pharmacol Exp Ther (2002) 303: 791-804 [PMID:12388666]
5-HT1D receptor in Human [GtoPdb: 3] [UniProtKB: P28221]
GtoPdb - - 7.8 pKi - - - J Pharmacol Exp Ther (2002) 303: 791-804 [PMID:12388666]
5-HT2A receptor in Human [GtoPdb: 6] [UniProtKB: P28223]
GtoPdb - - 8.3 pKi - - - J Pharmacol Exp Ther (2002) 303: 791-804 [PMID:12388666]
5-HT2B receptor in Human [GtoPdb: 7] [UniProtKB: P41595]
GtoPdb - - 8.2 pKi - - - J Pharmacol Exp Ther (2002) 303: 791-804 [PMID:12388666]
5-HT2C receptor in Human [GtoPdb: 8] [UniProtKB: P28335]
GtoPdb - - 7.3 pKi - - - J Pharmacol Exp Ther (2002) 303: 791-804 [PMID:12388666]
α1A-adrenoceptor in Human [GtoPdb: 22] [UniProtKB: P35348]
GtoPdb - - 8.5 pKi - - - J Pharmacol Exp Ther (2002) 303: 791-804 [PMID:12388666]
α2A-adrenoceptor in Human [GtoPdb: 25] [UniProtKB: P08913]
GtoPdb - - 9.5 pKi - - - J Pharmacol Exp Ther (2002) 303: 791-804 [PMID:12388666]
α2B-adrenoceptor in Human [GtoPdb: 26] [UniProtKB: P18089]
GtoPdb - - 9.4 pKi - - - J Pharmacol Exp Ther (2002) 303: 791-804 [PMID:12388666]
α2C-adrenoceptor in Human [GtoPdb: 27] [UniProtKB: P18825]
GtoPdb - - 9.1 pKi - - - J Pharmacol Exp Ther (2002) 303: 791-804 [PMID:12388666]
D3 receptor in Human [GtoPdb: 216] [UniProtKB: P35462]
GtoPdb - - 9 pKi - - - J Pharmacol Exp Ther (2002) 303: 791-804 [PMID:12388666]
D4 receptor in Human [GtoPdb: 217] [UniProtKB: P21917]
GtoPdb - - 8.1 pKi - - - J Pharmacol Exp Ther (2002) 303: 791-804 [PMID:12388666]

ChEMBL data shown on this page come from version 33:

Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]