HEMADO [Ligand Id: 5599] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL260563
  • A1 receptor/Adenosine A1 receptor in Human [ChEMBL: CHEMBL226] [GtoPdb: 18] [UniProtKB: P30542]
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  • A2A receptor/Adenosine A2a receptor in Human [ChEMBL: CHEMBL251] [GtoPdb: 19] [UniProtKB: P29274]
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  • A2B receptor/Adenosine A2b receptor in Human [ChEMBL: CHEMBL255] [GtoPdb: 20] [UniProtKB: P29275]
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  • A3 receptor/Adenosine A3 receptor in Human [ChEMBL: CHEMBL256] [GtoPdb: 21] [UniProtKB: P0DMS8]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
A1 receptor/Adenosine A1 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL226] [GtoPdb: 18] [UniProtKB: P30542]
GtoPdb - - 6.48 pKi 330 nM Ki J Med Chem (2002) 45: 3271-9 [PMID:12109910];
Eur J Pharmacol (2007) 556: 14-8 [PMID:17126322]
ChEMBL Binding affinity against Human recombinant Adenosine A1 receptor stably transfected in CHO cells using [3H]CCPA as radioligand B 6.49 pKi 327 nM Ki J Med Chem (2002) 45: 3271-3279 [PMID:12109910]
A2A receptor/Adenosine A2a receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL251] [GtoPdb: 19] [UniProtKB: P29274]
ChEMBL Binding affinity against Human recombinant Adenosine A2A receptor stably transfected in CHO cells using [3H]NECA as radioligand B 5.91 pKi 1230 nM Ki J Med Chem (2002) 45: 3271-3279 [PMID:12109910]
GtoPdb - - 5.92 pKi 1200 nM Ki J Med Chem (2002) 45: 3271-9 [PMID:12109910];
Eur J Pharmacol (2007) 556: 14-8 [PMID:17126322]
A2B receptor/Adenosine A2b receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL255] [GtoPdb: 20] [UniProtKB: P29275]
GtoPdb - - 4.52 pKi >30000 nM Ki J Med Chem (2002) 45: 3271-9 [PMID:12109910];
Eur J Pharmacol (2007) 556: 14-8 [PMID:17126322]
ChEMBL Receptor-stimulated activity in CHO cells stably transfected with Human recombinant Adenosine A2B receptor using [3H]NECA as radioligand B 4 pEC50 100000 nM EC50 J Med Chem (2002) 45: 3271-3279 [PMID:12109910]
ChEMBL Agonist activity at human adenosine A2B receptor expressed in CHO cells assessed as stimulation of adenylate cyclase F 5 pEC50 -5 - logEC50 J Med Chem (2008) 51: 2088-2099 [PMID:18321038]
A3 receptor/Adenosine A3 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL256] [GtoPdb: 21] [UniProtKB: P0DMS8]
ChEMBL Binding affinity against Human recombinant Adenosine A3 receptor stably transfected in CHO cells using [3H]NECA as radioligand B 8.96 pKi 1.1 nM Ki J Med Chem (2002) 45: 3271-3279 [PMID:12109910]
GtoPdb - - 8.96 pKi 1.1 nM Ki J Med Chem (2002) 45: 3271-9 [PMID:12109910];
Eur J Pharmacol (2007) 556: 14-8 [PMID:17126322]

ChEMBL data shown on this page come from version 32:

Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]