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Organic anion transporter 4

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Target not currently curated in GtoImmuPdb

Target id: 1030

Nomenclature: Organic anion transporter 4

Systematic Nomenclature: SLC22A11

Family: Organic anion transporters (OATs)

Contents:

Gene and Protein Information Click here for help
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human 12 550 11q13.1 SLC22A11 solute carrier family 22 member 11
Previous and Unofficial Names Click here for help
OAT4 | solute carrier family 22 (organic anion/urate transporter), member 11
Database Links Click here for help
Specialist databases
Bioparadigms SLC Tables SLC22A11 (Hs)
RESOLUTE SLC22A11 (Hs)
Other databases
Alphafold Q9NSA0 (Hs)
ChEMBL Target CHEMBL2073677 (Hs)
DrugBank Target Q9NSA0 (Hs)
Ensembl Gene ENSG00000168065 (Hs)
Entrez Gene 55867 (Hs)
Human Protein Atlas ENSG00000168065 (Hs)
KEGG Gene hsa:55867 (Hs)
OMIM 607097 (Hs)
Pharos Q9NSA0 (Hs)
UniProtKB Q9NSA0 (Hs)
Wikipedia SLC22A11 (Hs)
Substrates and Reaction Kinetics Click here for help
Substrate Sp. Property Value Units Standard property Standard value Assay description Assay conditions Comments Reference
dehydroepiandrosterone sulphate Hs - 1
ochratoxin A Hs - - 1
uric acid Hs - - 2
estrone-3-sulphate Hs - 1
Stoichiometry Click here for help
Unknown

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Inhibitors
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Value Parameter Reference
cefalotin Small molecule or natural product Approved drug Click here for species-specific activity table Ligand has a PDB structure Hs Inhibition 6.7 pKi 3
⤷ pKi 6.7 (Ki 2x10-7 M) [3]

References

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1. Cha SH, Sekine T, Kusuhara H, Yu E, Kim JY, Kim DK, Sugiyama Y, Kanai Y, Endou H. (2000) Molecular cloning and characterization of multispecific organic anion transporter 4 expressed in the placenta. J Biol Chem, 275 (6): 4507-12. [PMID:10660625]

2. Nigam SK, Bhatnagar V. (2018) The systems biology of uric acid transporters: the role of remote sensing and signaling. Curr Opin Nephrol Hypertens, 27 (4): 305-313. [PMID:29847376]

3. Takeda M, Babu E, Narikawa S, Endou H. (2002) Interaction of human organic anion transporters with various cephalosporin antibiotics. Eur J Pharmacol, 438 (3): 137-42. [PMID:11909604]

Contributors

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