RHC80267 [Ligand Id: 5255] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL158897 |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| diacylglycerol lipase α/Diacylglycerol lipase-alpha in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5545] [GtoPdb: 1396] [UniProtKB: Q9Y4D2] | ||||||||
| ChEMBL | Inhibition of human DAGLalpha | B | 4.19 | pIC50 | 65000 | nM | IC50 | Bioorg Med Chem Lett (2012) 22: 4585-4592 [PMID:22738638] |
| GtoPdb | - | - | 4.19 | pIC50 | 65000 | nM | IC50 | Bioorg Med Chem Lett (2012) 22: 4585-92 [PMID:22738638] |
| ChEMBL | Inhibition of human C-terminal HA-tagged DAGLalpha expressed in HEK293F cell membrane fractions using DiFMU-octanoate as substrate by fluorogenic surrogate substrate assay | B | 4.6 | pIC50 | 25118.86 | nM | IC50 | Bioorg Med Chem Lett (2016) 26: 3831-3837 [PMID:27394666] |
| ChEMBL | Inhibition of human C-terminal HA-tagged DAGLalpha expressed in HEK293F cell membrane fractions using PNP butyrate as substrate by colorimetric surrogate substrate assay | B | 5.3 | pIC50 | 5011.87 | nM | IC50 | Bioorg Med Chem Lett (2016) 26: 3831-3837 [PMID:27394666] |
| ChEMBL | Inhibition of human recombinant DAGLalpha overexpressed in african green monkey COS7 cells | B | 7.22 | pIC50 | 60 | nM | IC50 | Bioorg Med Chem Lett (2008) 18: 5838-5841 [PMID:18657971] |
| diacylglycerol lipase β/Diacylglycerol lipase-beta in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5521] [GtoPdb: 1397] [UniProtKB: Q8NCG7] | ||||||||
| ChEMBL | Inhibition of human recombinant DAGLbeta overexpressed in african green monkey COS7 cells | B | 7.22 | pIC50 | 60 | nM | IC50 | Bioorg Med Chem Lett (2008) 18: 5838-5841 [PMID:18657971] |
| Fatty acid amide hydrolase/Fatty-acid amide hydrolase 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2243] [GtoPdb: 1400] [UniProtKB: O00519] | ||||||||
| ChEMBL | Inhibition of recombinant FAAH transfected in HEK293T cells by SDS-PAGE using rhodamine-tagged FP probe | B | 4.15 | pIC50 | 70000 | nM | IC50 | Bioorg Med Chem Lett (2008) 18: 5838-5841 [PMID:18657971] |
| Fatty acid amide hydrolase/Fatty-acid amide hydrolase 1 in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3229] [GtoPdb: 1400] [UniProtKB: P97612] | ||||||||
| ChEMBL | Inhibition of rat histidine tagged FAAH expressed in Escherichia coli by coumarin ester substrate fluorescence assay | B | 5.65 | pIC50 | 2240 | nM | IC50 | Bioorg Med Chem Lett (2012) 22: 4585-4592 [PMID:22738638] |
| αβ-Hydrolase 12/Lysophosphatidylserine lipase ABHD12 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5516] [GtoPdb: 3070] [UniProtKB: Q8N2K0] | ||||||||
| ChEMBL | Inhibition of recombinant ABHD12 transfected in HEK293T cells by SDS-PAGE using rhodamine-tagged FP probe | B | 4 | pIC50 | >100000 | nM | IC50 | Bioorg Med Chem Lett (2008) 18: 5838-5841 [PMID:18657971] |
| Neutral cholesterol ester hydrolase 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5048] [UniProtKB: Q6PIU2] | ||||||||
| ChEMBL | Inhibition of recombinant KIAA1363 transfected in HEK293T cells by SDS-PAGE using rhodamine-tagged FP probe | B | 5 | pIC50 | 10000 | nM | IC50 | Bioorg Med Chem Lett (2008) 18: 5838-5841 [PMID:18657971] |
| Phosphatidylserine lipase ABHD16A in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL6168] [UniProtKB: O95870] | ||||||||
| ChEMBL | Inhibition of recombinant BAT5 transfected in HEK293T cells by SDS-PAGE using rhodamine-tagged FP probe | B | 4.64 | pIC50 | 23000 | nM | IC50 | Bioorg Med Chem Lett (2008) 18: 5838-5841 [PMID:18657971] |
| PLA2-G7/Platelet-activating factor acetylhydrolase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3514] [GtoPdb: 1432] [UniProtKB: Q13093] | ||||||||
| ChEMBL | Inhibition of recombinant PLA2g7 transfected in HEK293T cells by SDS-PAGE using rhodamine-tagged FP probe | B | 4.96 | pIC50 | 11000 | nM | IC50 | Bioorg Med Chem Lett (2008) 18: 5838-5841 [PMID:18657971] |
| Secreted mono- and diacylglycerol lipase LIP1 in Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)(Dandruff-associated fungus) (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3608197] [UniProtKB: A8PUY1] | ||||||||
| ChEMBL | Inhibition of Malassezia globosa CBS 7966 LIP1 using pNPA substrate | B | 4.12 | pIC50 | 75250 | nM | IC50 | Bioorg Med Chem Lett (2015) 25: 3464-3467 [PMID:26199121] |
ChEMBL data shown on this page come from version 36:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
