RHC80267 [Ligand Id: 5255] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL158897
  • Fatty acid amide hydrolase/Anandamide amidohydrolase in Human [ChEMBL: CHEMBL2243] [GtoPdb: 1400] [UniProtKB: O00519]
  • Fatty acid amide hydrolase/Anandamide amidohydrolase in Rat [ChEMBL: CHEMBL3229] [GtoPdb: 1400] [UniProtKB: P97612]
Created with Highcharts 10.3.3ValuesChart context menuAnandamide amidohydrolasepKd HumanpKi HumanpIC50 HumanpEC50 HumanpKd RatpKi RatpIC50 RatpEC50 Rat0123456Highcharts.com
  • PLA2-G7/LDL-associated phospholipase A2 in Human [ChEMBL: CHEMBL3514] [GtoPdb: 1432] [UniProtKB: Q13093]
Created with Highcharts 10.3.3ValuesChart context menuLDL-associated phospholipase A2pKd HumanpKi HumanpIC50 HumanpEC50 Human0123456Highcharts.com
  • LIP1, secretory lipase (Family 3) in Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)(Dandruff-associated fungus) [ChEMBL: CHEMBL3608197] [UniProtKB: A8PUY1]
Created with Highcharts 10.3.3ValuesChart context menuLIP1, secretory lipase (Family 3)pKd Malassezia globosa (strain ATCC MYA-4612 /​CBS 7966)(Dandruff-associated fungus)pKi Malassezia globosa (strain ATCC MYA-4612 / CBS​7966)(Dandruff-associated fungus)pIC50 Malassezia globosa (strain ATCC MYA-4612 /​CBS 7966)(Dandruff-associated fungus)pEC50 Malassezia globosa (strain ATCC MYA-4612 /​CBS 7966)(Dandruff-associated fungus)012345Highcharts.com
  • αβ-Hydrolase 12/Monoacylglycerol lipase ABHD12 in Human [ChEMBL: CHEMBL5516] [GtoPdb: 3070] [UniProtKB: Q8N2K0]
Created with Highcharts 10.3.3ValuesChart context menuMonoacylglycerol lipase ABHD12pKd HumanpKi HumanpIC50 HumanpEC50 Human012345Highcharts.com
  • Neutral cholesterol ester hydrolase 1 in Human [ChEMBL: CHEMBL5048] [UniProtKB: Q6PIU2]
Created with Highcharts 10.3.3ValuesChart context menuNeutral cholesterol ester hydrolase 1pKd HumanpKi HumanpIC50 HumanpEC50 Human0123456Highcharts.com
Created with Highcharts 10.3.3ValuesChart context menuProtein BAT5pKd HumanpKi HumanpIC50 HumanpEC50 Human012345Highcharts.com
  • diacylglycerol lipase α/Sn1-specific diacylglycerol lipase alpha in Human [ChEMBL: CHEMBL5545] [GtoPdb: 1396] [UniProtKB: Q9Y4D2]
Created with Highcharts 10.3.3ValuesChart context menuSn1-specific diacylglycerol lipase alphapKd HumanpKi HumanpIC50 HumanpEC50 Human02468Highcharts.com
  • diacylglycerol lipase β/Sn1-specific diacylglycerol lipase beta in Human [ChEMBL: CHEMBL5521] [GtoPdb: 1397] [UniProtKB: Q8NCG7]
Created with Highcharts 10.3.3ValuesChart context menuSn1-specific diacylglycerol lipase betapKd HumanpKi HumanpIC50 HumanpEC50 Human02468Highcharts.com
DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
Fatty acid amide hydrolase/Anandamide amidohydrolase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2243] [GtoPdb: 1400] [UniProtKB: O00519]
ChEMBL Inhibition of recombinant FAAH transfected in HEK293T cells by SDS-PAGE using rhodamine-tagged FP probe B 4.15 pIC50 70000 nM IC50 Bioorg Med Chem Lett (2008) 18: 5838-5841 [PMID:18657971]
Fatty acid amide hydrolase/Anandamide amidohydrolase in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3229] [GtoPdb: 1400] [UniProtKB: P97612]
ChEMBL Inhibition of rat histidine tagged FAAH expressed in Escherichia coli by coumarin ester substrate fluorescence assay B 5.65 pIC50 2240 nM IC50 Bioorg Med Chem Lett (2012) 22: 4585-4592 [PMID:22738638]
PLA2-G7/LDL-associated phospholipase A2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3514] [GtoPdb: 1432] [UniProtKB: Q13093]
ChEMBL Inhibition of recombinant PLA2g7 transfected in HEK293T cells by SDS-PAGE using rhodamine-tagged FP probe B 4.96 pIC50 11000 nM IC50 Bioorg Med Chem Lett (2008) 18: 5838-5841 [PMID:18657971]
LIP1, secretory lipase (Family 3) in Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)(Dandruff-associated fungus) (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3608197] [UniProtKB: A8PUY1]
ChEMBL Inhibition of Malassezia globosa CBS 7966 LIP1 using pNPA substrate B 4.12 pIC50 75250 nM IC50 Bioorg Med Chem Lett (2015) 25: 3464-3467 [PMID:26199121]
αβ-Hydrolase 12/Monoacylglycerol lipase ABHD12 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5516] [GtoPdb: 3070] [UniProtKB: Q8N2K0]
ChEMBL Inhibition of recombinant ABHD12 transfected in HEK293T cells by SDS-PAGE using rhodamine-tagged FP probe B 4 pIC50 >100000 nM IC50 Bioorg Med Chem Lett (2008) 18: 5838-5841 [PMID:18657971]
Neutral cholesterol ester hydrolase 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5048] [UniProtKB: Q6PIU2]
ChEMBL Inhibition of recombinant KIAA1363 transfected in HEK293T cells by SDS-PAGE using rhodamine-tagged FP probe B 5 pIC50 10000 nM IC50 Bioorg Med Chem Lett (2008) 18: 5838-5841 [PMID:18657971]
Protein BAT5 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL6168] [UniProtKB: O95870]
ChEMBL Inhibition of recombinant BAT5 transfected in HEK293T cells by SDS-PAGE using rhodamine-tagged FP probe B 4.64 pIC50 23000 nM IC50 Bioorg Med Chem Lett (2008) 18: 5838-5841 [PMID:18657971]
diacylglycerol lipase α/Sn1-specific diacylglycerol lipase alpha in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5545] [GtoPdb: 1396] [UniProtKB: Q9Y4D2]
ChEMBL Inhibition of human DAGLalpha B 4.19 pIC50 65000 nM IC50 Bioorg Med Chem Lett (2012) 22: 4585-4592 [PMID:22738638]
GtoPdb - - 4.19 pIC50 65000 nM IC50 Bioorg Med Chem Lett (2012) 22: 4585-92 [PMID:22738638]
ChEMBL Inhibition of human C-terminal HA-tagged DAGLalpha expressed in HEK293F cell membrane fractions using DiFMU-octanoate as substrate by fluorogenic surrogate substrate assay B 4.6 pIC50 25118.86 nM IC50 Bioorg Med Chem Lett (2016) 26: 3831-3837 [PMID:27394666]
ChEMBL Inhibition of human C-terminal HA-tagged DAGLalpha expressed in HEK293F cell membrane fractions using PNP butyrate as substrate by colorimetric surrogate substrate assay B 5.3 pIC50 5011.87 nM IC50 Bioorg Med Chem Lett (2016) 26: 3831-3837 [PMID:27394666]
ChEMBL Inhibition of human recombinant DAGLalpha overexpressed in african green monkey COS7 cells B 7.22 pIC50 60 nM IC50 Bioorg Med Chem Lett (2008) 18: 5838-5841 [PMID:18657971]
diacylglycerol lipase β/Sn1-specific diacylglycerol lipase beta in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5521] [GtoPdb: 1397] [UniProtKB: Q8NCG7]
ChEMBL Inhibition of human recombinant DAGLbeta overexpressed in african green monkey COS7 cells B 7.22 pIC50 60 nM IC50 Bioorg Med Chem Lett (2008) 18: 5838-5841 [PMID:18657971]

ChEMBL data shown on this page come from version 35:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]