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diacylglycerol lipase β
Target not currently curated in GtoImmuPdb
Target id: 1397
Nomenclature: diacylglycerol lipase β
Abbreviated Name: DAGLβ
Contents:
Gene and Protein Information  |
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| Species | TM | AA | Chromosomal Location | Gene Symbol | Gene Name | Reference |
| Human | 4 | 672 | 7p22.1 | DAGLB | diacylglycerol lipase beta | |
| Mouse | 4 | 669 | 5 G2 | Daglb | diacylglycerol lipase, beta | |
| Rat | 4 | 668 | 12p11 | Daglb | diacylglycerol lipase, beta | |
| Previous and Unofficial Names |
| diacylglycerol lipase | diacylglycerol lipase, beta | KCCR13L | neural stem cell-derived dendrite regulator | NSDDR |
| Database Links |
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| Alphafold | Q8NCG7 (Hs), Q91WC9 (Mm), P0C1S9 (Rn) |
| BRENDA | 3.1.1.- |
| CATH/Gene3D | 3.40.50.1820 |
| ChEMBL Target | CHEMBL5521 (Hs), CHEMBL5656 (Mm) |
| Ensembl Gene | ENSG00000164535 (Hs), ENSMUSG00000039206 (Mm), ENSRNOG00000001079 (Rn) |
| Entrez Gene | 221955 (Hs), 231871 (Mm), 304289 (Rn) |
| Human Protein Atlas | ENSG00000164535 (Hs) |
| KEGG Enzyme | 3.1.1.- |
| KEGG Gene | hsa:221955 (Hs), mmu:231871 (Mm), rno:304289 (Rn) |
| OMIM | 614016 (Hs) |
| Pharos | Q8NCG7 (Hs) |
| RefSeq Nucleotide | NM_001142936 (Hs), NM_144915 (Mm), NM_001107120 (Rn) |
| RefSeq Protein | NP_001136408 (Hs), NP_659164 (Mm), NP_001100590 (Rn) |
| UniProtKB | Q8NCG7 (Hs), Q91WC9 (Mm), P0C1S9 (Rn) |
| Wikipedia | DAGLB (Hs) |
| Enzyme Reaction |
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| Endogenous substrates |
| diacylglycerol |
Download all structure-activity data for this target as a CSV file 
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| Key to terms and symbols | View all chemical structures | Click column headers to sort | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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References
1. Baggelaar MP, Chameau PJ, Kantae V, Hummel J, Hsu KL, Janssen F, van der Wel T, Soethoudt M, Deng H, den Dulk H et al.. (2015) Highly Selective, Reversible Inhibitor Identified by Comparative Chemoproteomics Modulates Diacylglycerol Lipase Activity in Neurons. J Am Chem Soc, 137 (27): 8851-7. [PMID:26083464]
2. Bisogno T, Howell F, Williams G, Minassi A, Cascio MG, Ligresti A, Matias I, Schiano-Moriello A, Paul P, Williams EJ et al.. (2003) Cloning of the first sn1-DAG lipases points to the spatial and temporal regulation of endocannabinoid signaling in the brain. J Cell Biol, 163 (3): 463-8. [PMID:14610053]
3. Hsu KL, Tsuboi K, Adibekian A, Pugh H, Masuda K, Cravatt BF. (2012) DAGLβ inhibition perturbs a lipid network involved in macrophage inflammatory responses. Nat Chem Biol, 8 (12): 999-1007. [PMID:23103940]
4. Ogasawara D, Deng H, Viader A, Baggelaar MP, Breman A, den Dulk H, van den Nieuwendijk AM, van den Nieuwendijk AM, Soethoudt M, van der Wel T et al.. (2016) Rapid and profound rewiring of brain lipid signaling networks by acute diacylglycerol lipase inhibition. Proc Natl Acad Sci USA, 113 (1): 26-33. [PMID:26668358]
5. van Rooden EJ, Kohsiek M, Kreekel R, van Esbroeck ACM, van den Nieuwendijk AMCH, Janssen APA, van den Berg RJBHN, Overkleeft HS, van der Stelt M. (2018) Design and Synthesis of Quenched Activity-based Probes for Diacylglycerol Lipase and α,β-Hydrolase Domain Containing Protein 6. Chem Asian J, 13 (22): 3491-3500. [PMID:29901868]
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