VUF8507 [Ligand Id: 476] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL71053 (VUF-8507)
  • A1 receptor/Adenosine A1 receptor in Rat [ChEMBL: CHEMBL318] [GtoPdb: 18] [UniProtKB: P25099]
Created with Highcharts 10.3.3ValuesChart context menuAdenosine A1 receptorpKd RatpKi RatpIC50 RatpEC50 Rat0123456Highcharts.com
  • A3 receptor/Adenosine A3 receptor in Human [ChEMBL: CHEMBL256] [GtoPdb: 21] [UniProtKB: P0DMS8]
Created with Highcharts 10.3.3ValuesChart context menuAdenosine A3 receptorpKd HumanpKi HumanpIC50 HumanpEC50 Human02468Highcharts.com
DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
A1 receptor/Adenosine A1 receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL318] [GtoPdb: 18] [UniProtKB: P25099]
ChEMBL Displacement of [3H]DPCPX binding to adenosine A1 receptor of rat brain cortical membrane B 5.49 pKi 3200 nM Ki J Med Chem (2001) 44: 749-762 [PMID:11262085]
ChEMBL Displacement of [3H]DPCPX from adenosine A1 receptor of rat brain cortical membrane B 5.49 pKi 3200 nM Ki J Med Chem (2000) 43: 2227-2238 [PMID:10841801]
A3 receptor/Adenosine A3 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL256] [GtoPdb: 21] [UniProtKB: P0DMS8]
ChEMBL Tested for antagonist activity by displacement of specific [125I]AB-MECA binding at human Adenosine A3 receptor expressed in HEK 293 cells. B 3.7 pKi 200000 nM Ki J Med Chem (1998) 41: 3994-4000 [PMID:9767637]
ChEMBL Displacement of [125I]AB-MECA from human adenosine A3 receptor expressed in HEK 293 cells B 6.7 pKi 200 nM Ki J Med Chem (2001) 44: 749-762 [PMID:11262085]
ChEMBL Binding affinity by its ability to displace [125I]AB-MECA from human adenosine A3 receptor expressed in HEK 293 cells B 6.7 pKi 200 nM Ki J Med Chem (2000) 43: 2227-2238 [PMID:10841801]
ChEMBL Displacement of [3H]MRE 3008F20 from human adenosine A3 receptor expressed in CHO cells B 6.7 pKi 200 nM Ki J Med Chem (2006) 49: 4085-4097 [PMID:16821770]
GtoPdb - - 6.7 pKi - - - J Med Chem (1998) 41: 3994-4000 [PMID:9767637]

ChEMBL data shown on this page come from version 35:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]