ChEMBL ligand: CHEMBL897 (Benemid, Benuryl, HC 5006, NSC-18786, P-(dipropylsulfamoyl)benzoic acid, Probalan, Probampicin, Probecid, Probenate, Probenecid, Probenecidum)
ABCC2/Canalicular multispecific organic anion transporter 1 in Human [ChEMBL: CHEMBL5748] [GtoPdb: 780] [UniProtKB: Q92887] ABCC2/Canalicular multispecific organic anion transporter 1 in Rat [ChEMBL: CHEMBL2073676] [GtoPdb: 780] [UniProtKB: Q63120] There should be some charts here, you may need to enable JavaScript!
carbonic anhydrase 1/Carbonic anhydrase I in Human [ChEMBL: CHEMBL261] [GtoPdb: 2597] [UniProtKB: P00915] There should be some charts here, you may need to enable JavaScript!
carbonic anhydrase 2/Carbonic anhydrase II in Human [ChEMBL: CHEMBL205] [GtoPdb: 3092] [UniProtKB: P00918] There should be some charts here, you may need to enable JavaScript!
carbonic anhydrase 9/Carbonic anhydrase IX in Human [ChEMBL: CHEMBL3594] [GtoPdb: 3055] [UniProtKB: Q16790] There should be some charts here, you may need to enable JavaScript!
carbonic anhydrase 12/Carbonic anhydrase XII in Human [ChEMBL: CHEMBL3242] [GtoPdb: 2747] [UniProtKB: O43570] There should be some charts here, you may need to enable JavaScript!
Organic anion transporter 4/Solute carrier family 22 member 11 in Human [ChEMBL: CHEMBL2073677] [GtoPdb: 1030] [UniProtKB: Q9NSA0] There should be some charts here, you may need to enable JavaScript!
Urate anion exchanger 1/Solute carrier family 22 member 12 in Human [ChEMBL: CHEMBL6120] [GtoPdb: 1031] [UniProtKB: Q96S37] There should be some charts here, you may need to enable JavaScript!
OAT6/Solute carrier family 22 member 20 in Mouse [ChEMBL: CHEMBL5269] [GtoPdb: 1037] [UniProtKB: Q80UJ1] There should be some charts here, you may need to enable JavaScript!
Organic anion transporter 1/Solute carrier family 22 member 6 in Human [ChEMBL: CHEMBL1641347] [GtoPdb: 1025] [UniProtKB: Q4U2R8] Organic anion transporter 1/Solute carrier family 22 member 6 in Mouse [ChEMBL: CHEMBL5653] [GtoPdb: 1025] [UniProtKB: Q8VC69] Organic anion transporter 1/Solute carrier family 22 member 6 in Rat [ChEMBL: CHEMBL1777665] [GtoPdb: 1025] [UniProtKB: O35956] There should be some charts here, you may need to enable JavaScript!
Organic anion transporter 3/Solute carrier family 22 member 8 in Human [ChEMBL: CHEMBL1641348] [GtoPdb: 1027] [UniProtKB: Q8TCC7] Organic anion transporter 3/Solute carrier family 22 member 8 in Rat [ChEMBL: CHEMBL2073666] [GtoPdb: 1027] [UniProtKB: Q9R1U7] There should be some charts here, you may need to enable JavaScript!
Solute carrier organic anion transporter family member 1A1 in Rat [ChEMBL: CHEMBL1781859] [UniProtKB: P46720] There should be some charts here, you may need to enable JavaScript!
Solute carrier organic anion transporter family member 1A4 in Rat [ChEMBL: CHEMBL1781860] [UniProtKB: O35913] There should be some charts here, you may need to enable JavaScript!
UDP-glucuronosyltransferase 1-7 in Human [ChEMBL: CHEMBL1743317] [UniProtKB: Q9HAW7] There should be some charts here, you may need to enable JavaScript!
TRPV2 in Rat [GtoPdb: 508] [UniProtKB: Q9WUD2] There should be some charts here, you may need to enable JavaScript!
TAS2R16 in Human [GtoPdb: 669] [UniProtKB: Q9NYV7] There should be some charts here, you may need to enable JavaScript!
TAS2R38 in Human [GtoPdb: 682] [UniProtKB: P59533] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
ABCC2/Canalicular multispecific organic anion transporter 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5748] [GtoPdb: 780] [UniProtKB: Q92887]
ChEMBL	TP_TRANSPORTER: inhibition of SN-38 uptake in bile canalicular membrane vesicles	F	4.37	pKi	42200	nM	Ki	Drug Metabol Pharmacokin (2002) 17: 23-33 [PMID:15618649]
ABCC2/Canalicular multispecific organic anion transporter 1 in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2073676] [GtoPdb: 780] [UniProtKB: Q63120]
ChEMBL	TP_TRANSPORTER: inhibition of DNP-SG uptake in blie canalicular membrane vesicle from SD rat	F	4.35	pKi	44600	nM	Ki	Drug Metabol Pharmacokin (2002) 17: 23-33 [PMID:15618649]
carbonic anhydrase 1/Carbonic anhydrase I in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL261] [GtoPdb: 2597] [UniProtKB: P00915]
ChEMBL	Inhibition of recombinant human carbonic anhydrase 1 after 15 mins by stopped flow CO2 hydration assay	B	5	pKi	>10000	nM	Ki	Bioorg Med Chem (2014) 22: 3982-3988 [PMID:25027802]
ChEMBL	Inhibition of human carbonic anhydrase 1 by stopped-flow CO2 hydrase assay	B	5	pKi	>10000	nM	Ki	Bioorg Med Chem (2015) 23: 2975-2981 [PMID:26007302]
ChEMBL	Inhibition of human carbonic anhydrase-1 incubated for 15 mins by stopped-flow CO2 hydration assay	B	5	pKi	>10000	nM	Ki	Bioorg Med Chem (2015) 23: 5311-5318 [PMID:26264840]
carbonic anhydrase 2/Carbonic anhydrase II in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL205] [GtoPdb: 3092] [UniProtKB: P00918]
ChEMBL	Inhibition of recombinant human carbonic anhydrase 2 after 15 mins by stopped flow CO2 hydration assay	B	6.37	pKi	431	nM	Ki	Bioorg Med Chem (2014) 22: 3982-3988 [PMID:25027802]
ChEMBL	Inhibition of human carbonic anhydrase 2 by stopped-flow CO2 hydrase assay	B	6.37	pKi	431	nM	Ki	Bioorg Med Chem (2015) 23: 2975-2981 [PMID:26007302]
ChEMBL	Inhibition of human carbonic anhydrase-2 incubated for 15 mins by stopped-flow CO2 hydration assay	B	6.37	pKi	431	nM	Ki	Bioorg Med Chem (2015) 23: 5311-5318 [PMID:26264840]
carbonic anhydrase 9/Carbonic anhydrase IX in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3594] [GtoPdb: 3055] [UniProtKB: Q16790]
ChEMBL	Inhibition of recombinant human carbonic anhydrase 9 after 15 mins by stopped flow CO2 hydration assay	B	6.44	pKi	360	nM	Ki	Bioorg Med Chem (2014) 22: 3982-3988 [PMID:25027802]
ChEMBL	Inhibition of human carbonic anhydrase 9 by stopped-flow CO2 hydrase assay	B	6.44	pKi	360	nM	Ki	Bioorg Med Chem (2015) 23: 2975-2981 [PMID:26007302]
ChEMBL	Inhibition of human carbonic anhydrase-9 incubated for 15 mins by stopped-flow CO2 hydration assay	B	6.44	pKi	360	nM	Ki	Bioorg Med Chem (2015) 23: 5311-5318 [PMID:26264840]
carbonic anhydrase 12/Carbonic anhydrase XII in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3242] [GtoPdb: 2747] [UniProtKB: O43570]
ChEMBL	Inhibition of recombinant human carbonic anhydrase 12 after 15 mins by stopped flow CO2 hydration assay	B	5.9	pKi	1245	nM	Ki	Bioorg Med Chem (2014) 22: 3982-3988 [PMID:25027802]
ChEMBL	Inhibition of human carbonic anhydrase 12 by stopped-flow CO2 hydrase assay	B	5.9	pKi	1245	nM	Ki	Bioorg Med Chem (2015) 23: 2975-2981 [PMID:26007302]
ChEMBL	Inhibition of human carbonic anhydrase-12 incubated for 15 mins by stopped-flow CO2 hydration assay	B	5.9	pKi	1245	nM	Ki	Bioorg Med Chem (2015) 23: 5311-5318 [PMID:26264840]
Organic anion transporter 4/Solute carrier family 22 member 11 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2073677] [GtoPdb: 1030] [UniProtKB: Q9NSA0]
ChEMBL	TP_TRANSPORTER: inhibition of E1S uptake in OAT4-expressing S2 cells	F	4.26	pKi	54900	nM	Ki	J Pharmacol Exp Ther (2002) 301: 797-802 [PMID:12023506]
ChEMBL	TP_TRANSPORTER: inhibition of Ochratoxin A uptake in OAT4-expressing S2 cells	F	4.35	pKi	44400	nM	Ki	Biochim Biophys Acta (2002) 1590: 64-75 [PMID:12063169]
ChEMBL	Inhibition of OAT4 (unknown origin)	B	4.26	pIC50	54900	nM	IC50	Eur J Med Chem (2019) 166: 186-196 [PMID:30769179]
ChEMBL	TP_TRANSPORTER: inhibition of ES uptake (ES: 50nM) in hOAT4-expressing S2 cells	F	4.6	pIC50	25400	nM	IC50	J Pharmacol Sci (2004) 94: 197-202 [PMID:14978359]
Urate anion exchanger 1/Solute carrier family 22 member 12 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL6120] [GtoPdb: 1031] [UniProtKB: Q96S37]
ChEMBL	Inhibition of human URAT1 expressed in xenopus oocyte assessed as inhibition of [14C]-labelled urate uptake after 60 mins by liquid scintillation counting	B	4.06	pIC50	86390	nM	IC50	J Med Chem (2011) 54: 2701-2713 [PMID:21449597]
ChEMBL	Inhibition of human URAT1-mediated urate uptake in HEK293 cells	B	4.3	pIC50	50000	nM	IC50	Drug Metab Dispos (2007) 35: 981-986 [PMID:17325024]
ChEMBL	Inhibition of URAT1 (unknown origin)	B	4.82	pIC50	15000	nM	IC50	Medchemcomm (2016) 7: 1587-1595
OAT6/Solute carrier family 22 member 20 in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5269] [GtoPdb: 1037] [UniProtKB: Q80UJ1]
ChEMBL	Inhibition of mouse Oat6-mediated [3H]ES uptake in Xenopus oocytes after 1 hr	B	5.07	pKi	8511.38	nM	Ki	J Biol Chem (2007) 282: 23841-23853 [PMID:17553798]
ChEMBL	Inhibition of mouse Oat6-mediated [3H]ES uptake in Xenopus oocytes after 1 hr	B	5.08	pKi	8400	nM	Ki	J Biol Chem (2007) 282: 23841-23853 [PMID:17553798]
Organic anion transporter 1/Solute carrier family 22 member 6 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1641347] [GtoPdb: 1025] [UniProtKB: Q4U2R8]
ChEMBL	TP_TRANSPORTER: inhibition of PAH uptake in OAT1-expressing S2 cells	F	4.92	pKi	12100	nM	Ki	Eur J Pharmacol (2001) 419: 113-120 [PMID:11426832]
ChEMBL	TP_TRANSPORTER: inhibition of Ochratoxin A uptake in OAT1-expressing S2 cells	F	5.36	pKi	4410	nM	Ki	Life Sci (2001) 69: 2123-2135 [PMID:11669456]
ChEMBL	TP_TRANSPORTER: inhibition of PAH uptake in OAT1-expressing CHO cells	F	5.37	pKi	4300	nM	Ki	Anal Biochem (2000) 283: 49-55 [PMID:10929807]
GtoPdb	-	-	4.9	pIC50	12500	nM	IC50	Kidney Int (2003) 63: 143-55 [PMID:12472777]
ChEMBL	TP_TRANSPORTER: inhibition of Urate uptake (Urate: 300 uM) in OAT1-expressing S2 cells	F	4.9	pIC50	12500	nM	IC50	Kidney Int (2003) 63: 143-155 [PMID:12472777]
ChEMBL	TP_TRANSPORTER: inhibition of PHA uptake (PHA: 5uM) in hOAT1-expressing S2 cells	F	4.91	pIC50	12300	nM	IC50	J Pharmacol Sci (2004) 94: 197-202 [PMID:14978359]
ChEMBL	Inhibition of OAT1 (unknown origin)	B	4.92	pIC50	12100	nM	IC50	Eur J Med Chem (2019) 166: 186-196 [PMID:30769179]
ChEMBL	TP_TRANSPORTER: inhibition of Adefovir uptake in OAT1-expressing CHO cells	F	5.13	pIC50	7400	nM	IC50	J Pharmacol Exp Ther (2000) 295: 10-15 [PMID:10991954]
ChEMBL	TP_TRANSPORTER: inhibition of 6-Carboxyfluorescein uptake in OAT1-expressing CHO cells	F	5.2	pIC50	6300	nM	IC50	Anal Biochem (2000) 283: 49-55 [PMID:10929807]
Organic anion transporter 1/Solute carrier family 22 member 6 in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5653] [GtoPdb: 1025] [UniProtKB: Q8VC69]
ChEMBL	Inhibition of mouse Oat1-mediated [3H]PAH uptake in Xenopus oocytes after 1 hr	B	5.19	pKi	6400	nM	Ki	J Biol Chem (2007) 282: 23841-23853 [PMID:17553798]
ChEMBL	Inhibition of mouse Oat1-mediated [3H]PAH uptake in Xenopus oocytes after 1 hr	B	5.2	pKi	6309.57	nM	Ki	J Biol Chem (2007) 282: 23841-23853 [PMID:17553798]
Organic anion transporter 1/Solute carrier family 22 member 6 in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1777665] [GtoPdb: 1025] [UniProtKB: O35956]
ChEMBL	TP_TRANSPORTER: inhibition of PAH uptake in Oat1-expressing LLC-PK1 cells	F	4.51	pKi	31000	nM	Ki	J Pharmacol Exp Ther (2001) 298: 316-322 [PMID:11408557]
ChEMBL	TP_TRANSPORTER: inhibition of PAH uptake in Xenopus laevis oocytes	F	4.8	pKi	15800	nM	Ki	Eur J Pharmacol (2000) 409: 31-36 [PMID:11099697]
Organic anion transporter 3/Solute carrier family 22 member 8 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1641348] [GtoPdb: 1027] [UniProtKB: Q8TCC7]
ChEMBL	TP_TRANSPORTER: inhibition of MTX uptake in OAT3-expressing S2 cells	F	4.53	pKi	29800	nM	Ki	J Pharmacol Exp Ther (2002) 302: 666-671 [PMID:12130730]
ChEMBL	TP_TRANSPORTER: inhibition of E1S uptake in OAT3-expressing S2 cells	F	5.05	pKi	9000	nM	Ki	Eur J Pharmacol (2001) 419: 113-120 [PMID:11426832]
ChEMBL	TP_TRANSPORTER: inhibition of Ochratoxin A uptake in OAT3-expressing S2 cells	F	5.36	pKi	4410	nM	Ki	Life Sci (2001) 69: 2123-2135 [PMID:11669456]
ChEMBL	Inhibition of OAT3 (unknown origin)	B	5.05	pIC50	9000	nM	IC50	Eur J Med Chem (2019) 166: 186-196 [PMID:30769179]
ChEMBL	TP_TRANSPORTER: inhibition of ES uptake (ES: 50nM) in hOAT3-expressing S2 cells	F	5.31	pIC50	4930	nM	IC50	J Pharmacol Sci (2004) 94: 197-202 [PMID:14978359]
Organic anion transporter 3/Solute carrier family 22 member 8 in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2073666] [GtoPdb: 1027] [UniProtKB: Q9R1U7]
ChEMBL	TP_TRANSPORTER: inhibition of E217betaG uptake in Oat3-expressing LLC-PK1 cells	F	4.7	pKi	20000	nM	Ki	J Pharmacol Exp Ther (2001) 298: 316-322 [PMID:11408557]
ChEMBL	TP_TRANSPORTER: inhibition of PCG uptake in Oat3-expressing LLC-PK1 cells	F	5.35	pKi	4430	nM	Ki	Mol Pharmacol (2002) 61: 982-988 [PMID:11961115]
ChEMBL	TP_TRANSPORTER: inhibition of ES uptake (ES: 50nM) in rOAT3-expressing S2 cells	F	5.22	pIC50	6030	nM	IC50	J Pharmacol Sci (2004) 94: 197-202 [PMID:14978359]
Solute carrier organic anion transporter family member 1A1 in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1781859] [UniProtKB: P46720]
ChEMBL	TP_TRANSPORTER: inhibition of E217betaG uptake in Oatp1-expressing LLC-PK1 cells	F	4.13	pKi	74400	nM	Ki	J Pharmacol Exp Ther (2001) 298: 316-322 [PMID:11408557]
Solute carrier organic anion transporter family member 1A4 in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1781860] [UniProtKB: O35913]
ChEMBL	TP_TRANSPORTER: inhibition of E217betaG uptake in Oatp2-expressing LLC-PK1 cells	F	4.14	pKi	72900	nM	Ki	J Pharmacol Exp Ther (2001) 298: 316-322 [PMID:11408557]
UDP-glucuronosyltransferase 1-7 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1743317] [UniProtKB: Q9HAW7]
ChEMBL	Inhibition of 4-methylumbelliferone glucuronidation by human recombinant UGT1A7	B	4.02	pKi	96000	nM	Ki	Pharmacol Ther (2005) 106: 97-132 [PMID:15781124]
TRPV2 in Rat [GtoPdb: 508] [UniProtKB: Q9WUD2]
GtoPdb	-	-	4.5	pEC50	31900	nM	EC50	Neurosci Lett (2007) 425: 120-5 [PMID:17850966]
TAS2R16 in Human [GtoPdb: 669] [UniProtKB: Q9NYV7]
GtoPdb	-	-	3.53	pIC50	292000	nM	IC50	PLoS One (2011) 6: e20123 [PMID:21629661]
TAS2R38 in Human [GtoPdb: 682] [UniProtKB: P59533]
GtoPdb	-	-	3.68	pIC50	211000	nM	IC50	PLoS One (2011) 6: e20123 [PMID:21629661]

ChEMBL data shown on this page come from version 33:

Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]