salicylic acid [Ligand Id: 4306] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL424 (Acnisal, Bazuka, Compound v, Compound w, Cuplex verruca, Duofilm, Edinburgh, Erytex, FEMA NO. 3985, Freezone, Gppe paint, Jadit, K-557, Keralyt, Lamivudine impurity, salicylic acid-, Lamivudine related compound salicylic acid, Metanium, Necol, Noxacorn, NSC-180, Occlusal, Phiso-clear, Phytex, Phytocil, Posalfilin, Pyralvex, Salactol, Salatac, Salicylic acid, Salicylic acid rs, Thwart, Toepedo, Verrugon, Wartex)
Created with Highcharts 10.3.3ValuesChart context menuAmyloid-beta A4 proteinpKd HumanpKi HumanpIC50 HumanpEC50 Human01234567Highcharts.com
Created with Highcharts 10.3.3ValuesChart context menuCarbonic anhydrase 15pKd MousepKi MousepIC50 MousepEC50 Mouse0123456Highcharts.com
  • carbonic anhydrase 1/Carbonic anhydrase I in Human [ChEMBL: CHEMBL261] [GtoPdb: 2597] [UniProtKB: P00915]
Created with Highcharts 10.3.3ValuesChart context menuCarbonic anhydrase IpKd HumanpKi HumanpIC50 HumanpEC50 Human0123456Highcharts.com
  • carbonic anhydrase 2/Carbonic anhydrase II in Human [ChEMBL: CHEMBL205] [GtoPdb: 3092] [UniProtKB: P00918]
Created with Highcharts 10.3.3ValuesChart context menuCarbonic anhydrase IIpKd HumanpKi HumanpIC50 HumanpEC50 Human0123456Highcharts.com
  • carbonic anhydrase 4/Carbonic anhydrase IV in Human [ChEMBL: CHEMBL3729] [GtoPdb: 2599] [UniProtKB: P22748]
Created with Highcharts 10.3.3ValuesChart context menuCarbonic anhydrase IVpKd HumanpKi HumanpIC50 HumanpEC50 Human0123456Highcharts.com
  • carbonic anhydrase 9/Carbonic anhydrase IX in Human [ChEMBL: CHEMBL3594] [GtoPdb: 3055] [UniProtKB: Q16790]
Created with Highcharts 10.3.3ValuesChart context menuCarbonic anhydrase IXpKd HumanpKi HumanpIC50 HumanpEC50 Human012345Highcharts.com
Created with Highcharts 10.3.3ValuesChart context menuCarbonic anhydrase VIpKd HumanpKi HumanpIC50 HumanpEC50 Human0123456Highcharts.com
  • carbonic anhydrase 7/Carbonic anhydrase VII in Human [ChEMBL: CHEMBL2326] [GtoPdb: 2749] [UniProtKB: P43166]
Created with Highcharts 10.3.3ValuesChart context menuCarbonic anhydrase VIIpKd HumanpKi HumanpIC50 HumanpEC50 Human012345Highcharts.com
  • carbonic anhydrase 12/Carbonic anhydrase XII in Human [ChEMBL: CHEMBL3242] [GtoPdb: 2747] [UniProtKB: O43570]
Created with Highcharts 10.3.3ValuesChart context menuCarbonic anhydrase XIIpKd HumanpKi HumanpIC50 HumanpEC50 Human0123456Highcharts.com
  • carbonic anhydrase 13/Carbonic anhydrase XIII in Mouse [ChEMBL: CHEMBL2186] [GtoPdb: 2748] [UniProtKB: Q9D6N1]
Created with Highcharts 10.3.3ValuesChart context menuCarbonic anhydrase XIIIpKd MousepKi MousepIC50 MousepEC50 Mouse012345Highcharts.com
  • carbonic anhydrase 14/Carbonic anhydrase XIV in Human [ChEMBL: CHEMBL3510] [GtoPdb: 2598] [UniProtKB: Q9ULX7]
Created with Highcharts 10.3.3ValuesChart context menuCarbonic anhydrase XIVpKd HumanpKi HumanpIC50 HumanpEC50 Human012345Highcharts.com
Created with Highcharts 10.3.3ValuesChart context menuCyclooxygenase-1pKd HumanpKi HumanpIC50 HumanpEC50 Human012345Highcharts.com
Created with Highcharts 10.3.3ValuesChart context menuCyclooxygenase-2pKd HumanpKi HumanpIC50 HumanpEC50 Human012345Highcharts.com
  • high mobility group box 1/High mobility group protein B1 in Human [ChEMBL: CHEMBL2311236] [GtoPdb: 3279] [UniProtKB: P09429]
Created with Highcharts 10.3.3ValuesChart context menuHigh mobility group protein B1pKd HumanpKi HumanpIC50 HumanpEC50 Human01234567Highcharts.com
Created with Highcharts 10.3.3ValuesChart context menuNicotinate phosphoribosyltransferasepKd HumanpKi HumanpIC50 HumanpEC50 Human024681012Highcharts.com
  • OAT6/Solute carrier family 22 member 20 in Mouse [ChEMBL: CHEMBL5269] [GtoPdb: 1037] [UniProtKB: Q80UJ1]
Created with Highcharts 10.3.3ValuesChart context menuSolute carrier family 22 member 20pKd MousepKi MousepIC50 MousepEC50 Mouse012345Highcharts.com
Created with Highcharts 10.3.3ValuesChart context menuTyrosinasepKd Agaricus bisporuspKi Agaricus bisporuspIC50 Agaricus bisporuspEC50 Agaricus bisporus012345Highcharts.com
  • ASIC3 in Human [GtoPdb: 686] [UniProtKB: Q9UHC3]
Created with Highcharts 10.3.3ValuesChart context menuASIC3pKd HumanpKi HumanpIC50 HumanpEC50 Human01234Highcharts.com
DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
Amyloid-beta A4 protein in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2487] [UniProtKB: P05067]
ChEMBL Inhibitory activity against binding of [125I]IMSB to amyloid beta in brain B 5.74 pKi >1800 nM Ki J Med Chem (2001) 44: 2270-2275 [PMID:11428920]
Carbonic anhydrase 15 in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5973] [UniProtKB: Q99N23]
ChEMBL Inhibition of mouse recombinant carbonic anhydrase 15 by stopped-flow CO2 hydrase assay B 5.14 pKi 7200 nM Ki Bioorg Med Chem Lett (2008) 18: 3593-3596 [PMID:18501600]
carbonic anhydrase 1/Carbonic anhydrase I in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL261] [GtoPdb: 2597] [UniProtKB: P00915]
ChEMBL Inhibition of human carbonic anhydrase 1 by stopped-flow CO2 hydrase assay B 5 pKi 9920 nM Ki Bioorg Med Chem Lett (2008) 18: 3593-3596 [PMID:18501600]
ChEMBL Inhibition of human carbonic anhydrase 1 by stopped-flow CO2 hydration assay B 5 pKi 9900 nM Ki Bioorg Med Chem (2008) 16: 7424-7428 [PMID:18579385]
ChEMBL Inhibition of human carbonic anhydrase 1 incubated for 15 mins prior to testing by stopped flow CO2 hydration assay B 5 pKi 9900 nM Ki Bioorg Med Chem Lett (2015) 25: 5636-5641 [PMID:26520662]
carbonic anhydrase 2/Carbonic anhydrase II in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL205] [GtoPdb: 3092] [UniProtKB: P00918]
ChEMBL Inhibition of human carbonic anhydrase 2 by stopped-flow CO2 hydrase assay B 5.15 pKi 7120 nM Ki Bioorg Med Chem Lett (2008) 18: 3593-3596 [PMID:18501600]
ChEMBL Inhibition of human carbonic anhydrase 2 by stopped-flow CO2 hydration assay B 5.15 pKi 7100 nM Ki Bioorg Med Chem (2008) 16: 7424-7428 [PMID:18579385]
ChEMBL Inhibition of human carbonic anhydrase 2 incubated for 15 mins prior to testing by stopped flow CO2 hydration assay B 5.15 pKi 7100 nM Ki Bioorg Med Chem Lett (2015) 25: 5636-5641 [PMID:26520662]
carbonic anhydrase 4/Carbonic anhydrase IV in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3729] [GtoPdb: 2599] [UniProtKB: P22748]
ChEMBL Inhibition of human carbonic anhydrase 4 by stopped-flow CO2 hydration assay B 4.95 pKi 11100 nM Ki Bioorg Med Chem (2008) 16: 7424-7428 [PMID:18579385]
carbonic anhydrase 9/Carbonic anhydrase IX in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3594] [GtoPdb: 3055] [UniProtKB: Q16790]
ChEMBL Inhibition of human carbonic anhydrase 9 catalytic domain by stopped-flow CO2 hydration assay B 4.1 pKi 78700 nM Ki Bioorg Med Chem (2008) 16: 7424-7428 [PMID:18579385]
ChEMBL Inhibition of human carbonic anhydrase 9 incubated for 15 mins prior to testing by stopped flow CO2 hydration assay B 4.1 pKi 78700 nM Ki Bioorg Med Chem Lett (2015) 25: 5636-5641 [PMID:26520662]
Carbonic anhydrase VI in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3025] [UniProtKB: P23280]
ChEMBL Inhibition of human carbonic anhydrase 6 by stopped-flow CO2 hydration assay B 4.92 pKi 11900 nM Ki Bioorg Med Chem (2008) 16: 7424-7428 [PMID:18579385]
carbonic anhydrase 7/Carbonic anhydrase VII in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2326] [GtoPdb: 2749] [UniProtKB: P43166]
ChEMBL Inhibition of human carbonic anhydrase 7 by stopped-flow CO2 hydration assay B 4.09 pKi 82100 nM Ki Bioorg Med Chem (2008) 16: 7424-7428 [PMID:18579385]
carbonic anhydrase 12/Carbonic anhydrase XII in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3242] [GtoPdb: 2747] [UniProtKB: O43570]
ChEMBL Inhibition of human carbonic anhydrase 12 catalytic domain by stopped-flow CO2 hydration assay B 5.06 pKi 8800 nM Ki Bioorg Med Chem (2008) 16: 7424-7428 [PMID:18579385]
carbonic anhydrase 13/Carbonic anhydrase XIII in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2186] [GtoPdb: 2748] [UniProtKB: Q9D6N1]
ChEMBL Inhibition of mouse carbonic anhydrase 13 by stopped-flow CO2 hydration assay B 4.17 pKi 67000 nM Ki Bioorg Med Chem (2008) 16: 7424-7428 [PMID:18579385]
carbonic anhydrase 14/Carbonic anhydrase XIV in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3510] [GtoPdb: 2598] [UniProtKB: Q9ULX7]
ChEMBL Inhibition of human carbonic anhydrase 14 by stopped-flow CO2 hydration assay B 4.3 pKi 49800 nM Ki Bioorg Med Chem (2008) 16: 7424-7428 [PMID:18579385]
COX-1 /Cyclooxygenase-1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL221] [GtoPdb: 1375] [UniProtKB: P23219]
ChEMBL Inhibition of human COX1 assessed as reduction in PGF2alpha formation using arachidonic acid as substrate incubated for 10 mins by ELISA B 4.4 pIC50 >40000 nM IC50 Eur J Med Chem (2020) 193: 112217-112217 [PMID:32182488]
COX-2 /Cyclooxygenase-2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL230] [GtoPdb: 1376] [UniProtKB: P35354]
ChEMBL Inhibition of human COX2 assessed as reduction in PGF2alpha formation using arachidonic acid as substrate incubated for 10 mins by ELISA B 4.4 pIC50 >40000 nM IC50 Eur J Med Chem (2020) 193: 112217-112217 [PMID:32182488]
high mobility group box 1/High mobility group protein B1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2311236] [GtoPdb: 3279] [UniProtKB: P09429]
ChEMBL Binding affinity to recombinant HMGB1 box A (unknown origin) B 6 pKd 1000 nM Kd J Med Chem (2018) 61: 5093-5107 [PMID:29268019]
ChEMBL Binding affinity to recombinant HMGB1 box B (unknown origin) B 6 pKd 1000 nM Kd J Med Chem (2018) 61: 5093-5107 [PMID:29268019]
Nicotinate phosphoribosyltransferase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4523354] [UniProtKB: Q6XQN6]
ChEMBL Inhibition of NAPRT (unknown origin) B 9.8 pKi 0.16 nM Ki WO-2017162840-A1. Sensitization of cancer cells to nampt inhibitors by nicotinic acid phosphoribosyltransferase neutralization (2017)
OAT6/Solute carrier family 22 member 20 in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5269] [GtoPdb: 1037] [UniProtKB: Q80UJ1]
ChEMBL Inhibition of mouse Oat6-mediated [3H]ES uptake in Xenopus oocytes after 1 hr B 4.36 pKi 44000 nM Ki J Biol Chem (2007) 282: 23841-23853 [PMID:17553798]
ChEMBL Inhibition of mouse Oat6-mediated [3H]ES uptake in Xenopus oocytes after 1 hr B 4.36 pKi 43651.58 nM Ki J Biol Chem (2007) 282: 23841-23853 [PMID:17553798]
Tyrosinase in Agaricus bisporus (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3318] [UniProtKB: O42713]
ChEMBL Inhibition of mushroom tyrosinase after 10 mins B 4 pIC50 100000 nM IC50 J Med Chem (2011) 54: 591-602 [PMID:21189019]
ASIC3 in Human [GtoPdb: 686] [UniProtKB: Q9UHC3]
GtoPdb - - 3.6 pIC50 260000 nM IC50 J Neurosci (2001) 21: 8026-33 [PMID:11588175]

ChEMBL data shown on this page come from version 35:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]