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ChEMBL ligand: CHEMBL424 (Duofilm, Edinburgh, Salatac, Bazuka, Necol, Posalfilin, Acnisal, Compound W, Salactol, NSC-180, Duoplant, Duofilm Wart Remover, Phytex, Stri-Dex, Occlusal, Thwart, Verrugon, Toepedo, Salicylic acid rs, Ionil, Salicylic Acid Soap, Wartex, Cuplex Verruca, Saligel, Jadit, Advanced Pain Relief Callus Removers, Erytex, Freezone, Phiso-Clear, Advanced Pain Relief Com Removers, Compound V, K-557, Gppe Paint, Dr. Scholl's Corn Removers, Keralyt, Clear Away Wart Remover, 2-Hydroxy-benzoic acid, FEMA NO. 3985, Ionil-Plus, Dr. Scholl's Callus Removers, Lamivudine impurity, salicylic acid-, Phytocil, Dr. Scholl's Wart Remover Kit, Salicylic Acid, Noxacorn, Metanium, Pyralvex) |
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15
CHEMBL424_lig_chart_15
ASIC3
Human
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DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
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Beta amyloid A4 protein in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2487] [UniProtKB: P05067] | ||||||||
ChEMBL | Inhibitory activity against binding of [125I]IMSB to amyloid beta in brain | B | 5.74 | pKi | >1800 | nM | Ki | J. Med. Chem. (2001) 44: 2270-2275 [PMID:11428920] |
Carbonic anhydrase 15 in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5973] [UniProtKB: Q99N23] | ||||||||
ChEMBL | Inhibition of mouse recombinant carbonic anhydrase 15 by stopped-flow CO2 hydrase assay | B | 5.14 | pKi | 7200 | nM | Ki | Bioorg. Med. Chem. Lett. (2008) 18: 3593-3596 [PMID:18501600] |
carbonic anhydrase 1/Carbonic anhydrase I in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL261] [GtoPdb: 2597] [UniProtKB: P00915] | ||||||||
ChEMBL | Inhibition of human carbonic anhydrase 1 by stopped-flow CO2 hydrase assay | B | 5 | pKi | 9920 | nM | Ki | Bioorg. Med. Chem. Lett. (2008) 18: 3593-3596 [PMID:18501600] |
ChEMBL | Inhibition of human carbonic anhydrase 1 by stopped-flow CO2 hydration assay | B | 5 | pKi | 9900 | nM | Ki | Bioorg. Med. Chem. (2008) 16: 7424-7428 [PMID:18579385] |
ChEMBL | Inhibition of human carbonic anhydrase 1 incubated for 15 mins prior to testing by stopped flow CO2 hydration assay | B | 5 | pKi | 9900 | nM | Ki | Bioorg. Med. Chem. Lett. (2015) 25: 5636-5641 [PMID:26520662] |
carbonic anhydrase 2/Carbonic anhydrase II in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL205] [GtoPdb: 3092] [UniProtKB: P00918] | ||||||||
ChEMBL | Inhibition of human carbonic anhydrase 2 by stopped-flow CO2 hydrase assay | B | 5.15 | pKi | 7120 | nM | Ki | Bioorg. Med. Chem. Lett. (2008) 18: 3593-3596 [PMID:18501600] |
ChEMBL | Inhibition of human carbonic anhydrase 2 by stopped-flow CO2 hydration assay | B | 5.15 | pKi | 7100 | nM | Ki | Bioorg. Med. Chem. (2008) 16: 7424-7428 [PMID:18579385] |
ChEMBL | Inhibition of human carbonic anhydrase 2 incubated for 15 mins prior to testing by stopped flow CO2 hydration assay | B | 5.15 | pKi | 7100 | nM | Ki | Bioorg. Med. Chem. Lett. (2015) 25: 5636-5641 [PMID:26520662] |
carbonic anhydrase 4/Carbonic anhydrase IV in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3729] [GtoPdb: 2599] [UniProtKB: P22748] | ||||||||
ChEMBL | Inhibition of human carbonic anhydrase 4 by stopped-flow CO2 hydration assay | B | 4.95 | pKi | 11100 | nM | Ki | Bioorg. Med. Chem. (2008) 16: 7424-7428 [PMID:18579385] |
carbonic anhydrase 9/Carbonic anhydrase IX in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3594] [GtoPdb: 3055] [UniProtKB: Q16790] | ||||||||
ChEMBL | Inhibition of human carbonic anhydrase 9 catalytic domain by stopped-flow CO2 hydration assay | B | 4.1 | pKi | 78700 | nM | Ki | Bioorg. Med. Chem. (2008) 16: 7424-7428 [PMID:18579385] |
ChEMBL | Inhibition of human carbonic anhydrase 9 incubated for 15 mins prior to testing by stopped flow CO2 hydration assay | B | 4.1 | pKi | 78700 | nM | Ki | Bioorg. Med. Chem. Lett. (2015) 25: 5636-5641 [PMID:26520662] |
Carbonic anhydrase VI in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3025] [UniProtKB: P23280] | ||||||||
ChEMBL | Inhibition of human carbonic anhydrase 6 by stopped-flow CO2 hydration assay | B | 4.92 | pKi | 11900 | nM | Ki | Bioorg. Med. Chem. (2008) 16: 7424-7428 [PMID:18579385] |
carbonic anhydrase 7/Carbonic anhydrase VII in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2326] [GtoPdb: 2749] [UniProtKB: P43166] | ||||||||
ChEMBL | Inhibition of human carbonic anhydrase 7 by stopped-flow CO2 hydration assay | B | 4.09 | pKi | 82100 | nM | Ki | Bioorg. Med. Chem. (2008) 16: 7424-7428 [PMID:18579385] |
carbonic anhydrase 12/Carbonic anhydrase XII in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3242] [GtoPdb: 2747] [UniProtKB: O43570] | ||||||||
ChEMBL | Inhibition of human carbonic anhydrase 12 catalytic domain by stopped-flow CO2 hydration assay | B | 5.06 | pKi | 8800 | nM | Ki | Bioorg. Med. Chem. (2008) 16: 7424-7428 [PMID:18579385] |
carbonic anhydrase 13/Carbonic anhydrase XIII in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2186] [GtoPdb: 2748] [UniProtKB: Q9D6N1] | ||||||||
ChEMBL | Inhibition of mouse carbonic anhydrase 13 by stopped-flow CO2 hydration assay | B | 4.17 | pKi | 67000 | nM | Ki | Bioorg. Med. Chem. (2008) 16: 7424-7428 [PMID:18579385] |
carbonic anhydrase 14/Carbonic anhydrase XIV in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3510] [GtoPdb: 2598] [UniProtKB: Q9ULX7] | ||||||||
ChEMBL | Inhibition of human carbonic anhydrase 14 by stopped-flow CO2 hydration assay | B | 4.3 | pKi | 49800 | nM | Ki | Bioorg. Med. Chem. (2008) 16: 7424-7428 [PMID:18579385] |
High mobility group protein B1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2311236] [UniProtKB: P09429] | ||||||||
ChEMBL | Binding affinity to recombinant HMGB1 box A (unknown origin) | B | 6 | pKd | 1000 | nM | Kd | J Med Chem (2018) 61: 5093-5107 [PMID:29268019] |
ChEMBL | Binding affinity to recombinant HMGB1 box B (unknown origin) | B | 6 | pKd | 1000 | nM | Kd | J Med Chem (2018) 61: 5093-5107 [PMID:29268019] |
OAT6/Solute carrier family 22 member 20 in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5269] [GtoPdb: 1037] [UniProtKB: Q80UJ1] | ||||||||
ChEMBL | Inhibition of mouse Oat6-mediated [3H]ES uptake in Xenopus oocytes after 1 hr | B | 4.36 | pKi | 44000 | nM | Ki | J. Biol. Chem. (2007) 282: 23841-23853 [PMID:17553798] |
ChEMBL | Inhibition of mouse Oat6-mediated [3H]ES uptake in Xenopus oocytes after 1 hr | B | 4.36 | pKi | 43651.58 | nM | Ki | J. Biol. Chem. (2007) 282: 23841-23853 [PMID:17553798] |
Tyrosinase in Agaricus bisporus (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3318] [UniProtKB: O42713] | ||||||||
ChEMBL | Inhibition of mushroom tyrosinase after 10 mins | B | 4 | pIC50 | 100000 | nM | IC50 | J. Med. Chem. (2011) 54: 591-602 [PMID:21189019] |
ASIC3 in Human [GtoPdb: 686] [UniProtKB: Q9UHC3] | ||||||||
GtoPdb | - | - | 3.6 | pIC50 | 260000 | nM | IC50 | J. Neurosci. (2001) 21: 8026-33 [PMID:11588175] |
ChEMBL data shown on this page come from version 27:
Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, CibriƔn-Uhalte E, Davies M, Dedman N, Karlsson A, MagariƱos MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]