salicylic acid [Ligand Id: 4306] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL424 (Duofilm, Edinburgh, Salatac, Bazuka, Necol, Posalfilin, Acnisal, Compound W, Salactol, NSC-180, Duoplant, Duofilm Wart Remover, Phytex, Stri-Dex, Occlusal, Thwart, Verrugon, Toepedo, Salicylic acid rs, Ionil, Salicylic Acid Soap, Wartex, Cuplex Verruca, Saligel, Jadit, Advanced Pain Relief Callus Removers, Erytex, Freezone, Phiso-Clear, Advanced Pain Relief Com Removers, Compound V, K-557, Gppe Paint, Dr. Scholl's Corn Removers, Keralyt, Clear Away Wart Remover, 2-Hydroxy-benzoic acid, FEMA NO. 3985, Ionil-Plus, Dr. Scholl's Callus Removers, Lamivudine impurity, salicylic acid-, Phytocil, Dr. Scholl's Wart Remover Kit, Salicylic Acid, Noxacorn, Metanium, Pyralvex)
  • Beta amyloid A4 protein in Human [ChEMBL: CHEMBL2487] [UniProtKB: P05067]
  • This target only has 1 pki data point
1 CHEMBL424_lig_chart_1 Beta amyloid A4 protein Human
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  • Carbonic anhydrase 15 in Mouse [ChEMBL: CHEMBL5973] [UniProtKB: Q99N23]
  • This target only has 1 pki data point
2 CHEMBL424_lig_chart_2 Carbonic anhydrase 15 Mouse
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  • carbonic anhydrase 1/Carbonic anhydrase I in Human [ChEMBL: CHEMBL261] [GtoPdb: 2597] [UniProtKB: P00915]
3 CHEMBL424_lig_chart_3 Carbonic anhydrase I Human
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  • carbonic anhydrase 2/Carbonic anhydrase II in Human [ChEMBL: CHEMBL205] [GtoPdb: 3092] [UniProtKB: P00918]
4 CHEMBL424_lig_chart_4 Carbonic anhydrase II Human
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  • carbonic anhydrase 4/Carbonic anhydrase IV in Human [ChEMBL: CHEMBL3729] [GtoPdb: 2599] [UniProtKB: P22748]
  • This target only has 1 pki data point
5 CHEMBL424_lig_chart_5 Carbonic anhydrase IV Human
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  • carbonic anhydrase 9/Carbonic anhydrase IX in Human [ChEMBL: CHEMBL3594] [GtoPdb: 3055] [UniProtKB: Q16790]
6 CHEMBL424_lig_chart_6 Carbonic anhydrase IX Human
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  • Carbonic anhydrase VI in Human [ChEMBL: CHEMBL3025] [UniProtKB: P23280]
  • This target only has 1 pki data point
7 CHEMBL424_lig_chart_7 Carbonic anhydrase VI Human
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  • carbonic anhydrase 7/Carbonic anhydrase VII in Human [ChEMBL: CHEMBL2326] [GtoPdb: 2749] [UniProtKB: P43166]
  • This target only has 1 pki data point
8 CHEMBL424_lig_chart_8 Carbonic anhydrase VII Human
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  • carbonic anhydrase 12/Carbonic anhydrase XII in Human [ChEMBL: CHEMBL3242] [GtoPdb: 2747] [UniProtKB: O43570]
  • This target only has 1 pki data point
9 CHEMBL424_lig_chart_9 Carbonic anhydrase XII Human
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  • carbonic anhydrase 13/Carbonic anhydrase XIII in Mouse [ChEMBL: CHEMBL2186] [GtoPdb: 2748] [UniProtKB: Q9D6N1]
  • This target only has 1 pki data point
10 CHEMBL424_lig_chart_10 Carbonic anhydrase XIII Mouse
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  • carbonic anhydrase 14/Carbonic anhydrase XIV in Human [ChEMBL: CHEMBL3510] [GtoPdb: 2598] [UniProtKB: Q9ULX7]
  • This target only has 1 pki data point
11 CHEMBL424_lig_chart_11 Carbonic anhydrase XIV Human
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  • High mobility group protein B1 in Human [ChEMBL: CHEMBL2311236] [UniProtKB: P09429]
  • This target only has 0 pki data point
12 CHEMBL424_lig_chart_12 High mobility group protein B1 Human
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  • OAT6/Solute carrier family 22 member 20 in Mouse [ChEMBL: CHEMBL5269] [GtoPdb: 1037] [UniProtKB: Q80UJ1]
13 CHEMBL424_lig_chart_13 Solute carrier family 22 member 20 Mouse
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  • Tyrosinase in Agaricus bisporus [ChEMBL: CHEMBL3318] [UniProtKB: O42713]
  • This target only has 0 pki data point
14 CHEMBL424_lig_chart_14 Tyrosinase Agaricus bisporus
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  • ASIC3 in Human [GtoPdb: 686] [UniProtKB: Q9UHC3]
  • This target only has 0 pki data point
15 CHEMBL424_lig_chart_15 ASIC3 Human
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
Beta amyloid A4 protein in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2487] [UniProtKB: P05067]
ChEMBL Inhibitory activity against binding of [125I]IMSB to amyloid beta in brain B 5.74 pKi >1800 nM Ki J. Med. Chem. (2001) 44: 2270-2275 [PMID:11428920]
Carbonic anhydrase 15 in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5973] [UniProtKB: Q99N23]
ChEMBL Inhibition of mouse recombinant carbonic anhydrase 15 by stopped-flow CO2 hydrase assay B 5.14 pKi 7200 nM Ki Bioorg. Med. Chem. Lett. (2008) 18: 3593-3596 [PMID:18501600]
carbonic anhydrase 1/Carbonic anhydrase I in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL261] [GtoPdb: 2597] [UniProtKB: P00915]
ChEMBL Inhibition of human carbonic anhydrase 1 by stopped-flow CO2 hydrase assay B 5 pKi 9920 nM Ki Bioorg. Med. Chem. Lett. (2008) 18: 3593-3596 [PMID:18501600]
ChEMBL Inhibition of human carbonic anhydrase 1 by stopped-flow CO2 hydration assay B 5 pKi 9900 nM Ki Bioorg. Med. Chem. (2008) 16: 7424-7428 [PMID:18579385]
ChEMBL Inhibition of human carbonic anhydrase 1 incubated for 15 mins prior to testing by stopped flow CO2 hydration assay B 5 pKi 9900 nM Ki Bioorg. Med. Chem. Lett. (2015) 25: 5636-5641 [PMID:26520662]
carbonic anhydrase 2/Carbonic anhydrase II in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL205] [GtoPdb: 3092] [UniProtKB: P00918]
ChEMBL Inhibition of human carbonic anhydrase 2 by stopped-flow CO2 hydrase assay B 5.15 pKi 7120 nM Ki Bioorg. Med. Chem. Lett. (2008) 18: 3593-3596 [PMID:18501600]
ChEMBL Inhibition of human carbonic anhydrase 2 by stopped-flow CO2 hydration assay B 5.15 pKi 7100 nM Ki Bioorg. Med. Chem. (2008) 16: 7424-7428 [PMID:18579385]
ChEMBL Inhibition of human carbonic anhydrase 2 incubated for 15 mins prior to testing by stopped flow CO2 hydration assay B 5.15 pKi 7100 nM Ki Bioorg. Med. Chem. Lett. (2015) 25: 5636-5641 [PMID:26520662]
carbonic anhydrase 4/Carbonic anhydrase IV in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3729] [GtoPdb: 2599] [UniProtKB: P22748]
ChEMBL Inhibition of human carbonic anhydrase 4 by stopped-flow CO2 hydration assay B 4.95 pKi 11100 nM Ki Bioorg. Med. Chem. (2008) 16: 7424-7428 [PMID:18579385]
carbonic anhydrase 9/Carbonic anhydrase IX in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3594] [GtoPdb: 3055] [UniProtKB: Q16790]
ChEMBL Inhibition of human carbonic anhydrase 9 catalytic domain by stopped-flow CO2 hydration assay B 4.1 pKi 78700 nM Ki Bioorg. Med. Chem. (2008) 16: 7424-7428 [PMID:18579385]
ChEMBL Inhibition of human carbonic anhydrase 9 incubated for 15 mins prior to testing by stopped flow CO2 hydration assay B 4.1 pKi 78700 nM Ki Bioorg. Med. Chem. Lett. (2015) 25: 5636-5641 [PMID:26520662]
Carbonic anhydrase VI in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3025] [UniProtKB: P23280]
ChEMBL Inhibition of human carbonic anhydrase 6 by stopped-flow CO2 hydration assay B 4.92 pKi 11900 nM Ki Bioorg. Med. Chem. (2008) 16: 7424-7428 [PMID:18579385]
carbonic anhydrase 7/Carbonic anhydrase VII in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2326] [GtoPdb: 2749] [UniProtKB: P43166]
ChEMBL Inhibition of human carbonic anhydrase 7 by stopped-flow CO2 hydration assay B 4.09 pKi 82100 nM Ki Bioorg. Med. Chem. (2008) 16: 7424-7428 [PMID:18579385]
carbonic anhydrase 12/Carbonic anhydrase XII in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3242] [GtoPdb: 2747] [UniProtKB: O43570]
ChEMBL Inhibition of human carbonic anhydrase 12 catalytic domain by stopped-flow CO2 hydration assay B 5.06 pKi 8800 nM Ki Bioorg. Med. Chem. (2008) 16: 7424-7428 [PMID:18579385]
carbonic anhydrase 13/Carbonic anhydrase XIII in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2186] [GtoPdb: 2748] [UniProtKB: Q9D6N1]
ChEMBL Inhibition of mouse carbonic anhydrase 13 by stopped-flow CO2 hydration assay B 4.17 pKi 67000 nM Ki Bioorg. Med. Chem. (2008) 16: 7424-7428 [PMID:18579385]
carbonic anhydrase 14/Carbonic anhydrase XIV in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3510] [GtoPdb: 2598] [UniProtKB: Q9ULX7]
ChEMBL Inhibition of human carbonic anhydrase 14 by stopped-flow CO2 hydration assay B 4.3 pKi 49800 nM Ki Bioorg. Med. Chem. (2008) 16: 7424-7428 [PMID:18579385]
High mobility group protein B1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2311236] [UniProtKB: P09429]
ChEMBL Binding affinity to recombinant HMGB1 box A (unknown origin) B 6 pKd 1000 nM Kd J Med Chem (2018) 61: 5093-5107 [PMID:29268019]
ChEMBL Binding affinity to recombinant HMGB1 box B (unknown origin) B 6 pKd 1000 nM Kd J Med Chem (2018) 61: 5093-5107 [PMID:29268019]
OAT6/Solute carrier family 22 member 20 in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5269] [GtoPdb: 1037] [UniProtKB: Q80UJ1]
ChEMBL Inhibition of mouse Oat6-mediated [3H]ES uptake in Xenopus oocytes after 1 hr B 4.36 pKi 44000 nM Ki J. Biol. Chem. (2007) 282: 23841-23853 [PMID:17553798]
ChEMBL Inhibition of mouse Oat6-mediated [3H]ES uptake in Xenopus oocytes after 1 hr B 4.36 pKi 43651.58 nM Ki J. Biol. Chem. (2007) 282: 23841-23853 [PMID:17553798]
Tyrosinase in Agaricus bisporus (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3318] [UniProtKB: O42713]
ChEMBL Inhibition of mushroom tyrosinase after 10 mins B 4 pIC50 100000 nM IC50 J. Med. Chem. (2011) 54: 591-602 [PMID:21189019]
ASIC3 in Human [GtoPdb: 686] [UniProtKB: Q9UHC3]
GtoPdb - - 3.6 pIC50 260000 nM IC50 J. Neurosci. (2001) 21: 8026-33 [PMID:11588175]

ChEMBL data shown on this page come from version 27:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, CibriƔn-Uhalte E, Davies M, Dedman N, Karlsson A, MagariƱos MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]