ChEMBL ligand: CHEMBL424 (Duofilm, Edinburgh, Salatac, Bazuka, Necol, Posalfilin, Acnisal, Compound W, Salactol, NSC-180, Duoplant, Duofilm Wart Remover, Phytex, Stri-Dex, Occlusal, Thwart, Verrugon, Toepedo, Salicylic acid rs, Ionil, Salicylic Acid Soap, Wartex, Cuplex Verruca, Saligel, Jadit, Advanced Pain Relief Callus Removers, Erytex, Freezone, Phiso-Clear, Advanced Pain Relief Com Removers, Compound V, K-557, Gppe Paint, Dr. Scholl's Corn Removers, Keralyt, Clear Away Wart Remover, 2-Hydroxy-benzoic acid, FEMA NO. 3985, Ionil-Plus, Dr. Scholl's Callus Removers, Lamivudine impurity, salicylic acid-, Phytocil, Dr. Scholl's Wart Remover Kit, Salicylic Acid, Noxacorn, Metanium, Pyralvex)
Beta amyloid A4 protein in Human [ChEMBL: CHEMBL2487] [UniProtKB: P05067] This target only has 1 pki data point 1 CHEMBL424_lig_chart_1 Beta amyloid A4 protein Human There should be some charts here, you may need to enable JavaScript!
Carbonic anhydrase 15 in Mouse [ChEMBL: CHEMBL5973] [UniProtKB: Q99N23] This target only has 1 pki data point 2 CHEMBL424_lig_chart_2 Carbonic anhydrase 15 Mouse There should be some charts here, you may need to enable JavaScript!
carbonic anhydrase 1/Carbonic anhydrase I in Human [ChEMBL: CHEMBL261] [GtoPdb: 2597] [UniProtKB: P00915] 3 CHEMBL424_lig_chart_3 Carbonic anhydrase I Human There should be some charts here, you may need to enable JavaScript!
carbonic anhydrase 2/Carbonic anhydrase II in Human [ChEMBL: CHEMBL205] [GtoPdb: 3092] [UniProtKB: P00918] 4 CHEMBL424_lig_chart_4 Carbonic anhydrase II Human There should be some charts here, you may need to enable JavaScript!
carbonic anhydrase 4/Carbonic anhydrase IV in Human [ChEMBL: CHEMBL3729] [GtoPdb: 2599] [UniProtKB: P22748] This target only has 1 pki data point 5 CHEMBL424_lig_chart_5 Carbonic anhydrase IV Human There should be some charts here, you may need to enable JavaScript!
carbonic anhydrase 9/Carbonic anhydrase IX in Human [ChEMBL: CHEMBL3594] [GtoPdb: 3055] [UniProtKB: Q16790] 6 CHEMBL424_lig_chart_6 Carbonic anhydrase IX Human There should be some charts here, you may need to enable JavaScript!
Carbonic anhydrase VI in Human [ChEMBL: CHEMBL3025] [UniProtKB: P23280] This target only has 1 pki data point 7 CHEMBL424_lig_chart_7 Carbonic anhydrase VI Human There should be some charts here, you may need to enable JavaScript!
carbonic anhydrase 7/Carbonic anhydrase VII in Human [ChEMBL: CHEMBL2326] [GtoPdb: 2749] [UniProtKB: P43166] This target only has 1 pki data point 8 CHEMBL424_lig_chart_8 Carbonic anhydrase VII Human There should be some charts here, you may need to enable JavaScript!
carbonic anhydrase 12/Carbonic anhydrase XII in Human [ChEMBL: CHEMBL3242] [GtoPdb: 2747] [UniProtKB: O43570] This target only has 1 pki data point 9 CHEMBL424_lig_chart_9 Carbonic anhydrase XII Human There should be some charts here, you may need to enable JavaScript!
carbonic anhydrase 13/Carbonic anhydrase XIII in Mouse [ChEMBL: CHEMBL2186] [GtoPdb: 2748] [UniProtKB: Q9D6N1] This target only has 1 pki data point 10 CHEMBL424_lig_chart_10 Carbonic anhydrase XIII Mouse There should be some charts here, you may need to enable JavaScript!
carbonic anhydrase 14/Carbonic anhydrase XIV in Human [ChEMBL: CHEMBL3510] [GtoPdb: 2598] [UniProtKB: Q9ULX7] This target only has 1 pki data point 11 CHEMBL424_lig_chart_11 Carbonic anhydrase XIV Human There should be some charts here, you may need to enable JavaScript!
High mobility group protein B1 in Human [ChEMBL: CHEMBL2311236] [UniProtKB: P09429] This target only has 0 pki data point 12 CHEMBL424_lig_chart_12 High mobility group protein B1 Human There should be some charts here, you may need to enable JavaScript!
OAT6/Solute carrier family 22 member 20 in Mouse [ChEMBL: CHEMBL5269] [GtoPdb: 1037] [UniProtKB: Q80UJ1] 13 CHEMBL424_lig_chart_13 Solute carrier family 22 member 20 Mouse There should be some charts here, you may need to enable JavaScript!
Tyrosinase in Agaricus bisporus [ChEMBL: CHEMBL3318] [UniProtKB: O42713] This target only has 0 pki data point 14 CHEMBL424_lig_chart_14 Tyrosinase Agaricus bisporus There should be some charts here, you may need to enable JavaScript!
ASIC3 in Human [GtoPdb: 686] [UniProtKB: Q9UHC3] This target only has 0 pki data point 15 CHEMBL424_lig_chart_15 ASIC3 Human There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
Beta amyloid A4 protein in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2487] [UniProtKB: P05067]
ChEMBL	Inhibitory activity against binding of [125I]IMSB to amyloid beta in brain	B	5.74	pKi	>1800	nM	Ki	J. Med. Chem. (2001) 44: 2270-2275 [PMID:11428920]
Carbonic anhydrase 15 in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5973] [UniProtKB: Q99N23]
ChEMBL	Inhibition of mouse recombinant carbonic anhydrase 15 by stopped-flow CO2 hydrase assay	B	5.14	pKi	7200	nM	Ki	Bioorg. Med. Chem. Lett. (2008) 18: 3593-3596 [PMID:18501600]
carbonic anhydrase 1/Carbonic anhydrase I in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL261] [GtoPdb: 2597] [UniProtKB: P00915]
ChEMBL	Inhibition of human carbonic anhydrase 1 by stopped-flow CO2 hydrase assay	B	5	pKi	9920	nM	Ki	Bioorg. Med. Chem. Lett. (2008) 18: 3593-3596 [PMID:18501600]
ChEMBL	Inhibition of human carbonic anhydrase 1 by stopped-flow CO2 hydration assay	B	5	pKi	9900	nM	Ki	Bioorg. Med. Chem. (2008) 16: 7424-7428 [PMID:18579385]
ChEMBL	Inhibition of human carbonic anhydrase 1 incubated for 15 mins prior to testing by stopped flow CO2 hydration assay	B	5	pKi	9900	nM	Ki	Bioorg. Med. Chem. Lett. (2015) 25: 5636-5641 [PMID:26520662]
carbonic anhydrase 2/Carbonic anhydrase II in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL205] [GtoPdb: 3092] [UniProtKB: P00918]
ChEMBL	Inhibition of human carbonic anhydrase 2 by stopped-flow CO2 hydrase assay	B	5.15	pKi	7120	nM	Ki	Bioorg. Med. Chem. Lett. (2008) 18: 3593-3596 [PMID:18501600]
ChEMBL	Inhibition of human carbonic anhydrase 2 by stopped-flow CO2 hydration assay	B	5.15	pKi	7100	nM	Ki	Bioorg. Med. Chem. (2008) 16: 7424-7428 [PMID:18579385]
ChEMBL	Inhibition of human carbonic anhydrase 2 incubated for 15 mins prior to testing by stopped flow CO2 hydration assay	B	5.15	pKi	7100	nM	Ki	Bioorg. Med. Chem. Lett. (2015) 25: 5636-5641 [PMID:26520662]
carbonic anhydrase 4/Carbonic anhydrase IV in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3729] [GtoPdb: 2599] [UniProtKB: P22748]
ChEMBL	Inhibition of human carbonic anhydrase 4 by stopped-flow CO2 hydration assay	B	4.95	pKi	11100	nM	Ki	Bioorg. Med. Chem. (2008) 16: 7424-7428 [PMID:18579385]
carbonic anhydrase 9/Carbonic anhydrase IX in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3594] [GtoPdb: 3055] [UniProtKB: Q16790]
ChEMBL	Inhibition of human carbonic anhydrase 9 catalytic domain by stopped-flow CO2 hydration assay	B	4.1	pKi	78700	nM	Ki	Bioorg. Med. Chem. (2008) 16: 7424-7428 [PMID:18579385]
ChEMBL	Inhibition of human carbonic anhydrase 9 incubated for 15 mins prior to testing by stopped flow CO2 hydration assay	B	4.1	pKi	78700	nM	Ki	Bioorg. Med. Chem. Lett. (2015) 25: 5636-5641 [PMID:26520662]
Carbonic anhydrase VI in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3025] [UniProtKB: P23280]
ChEMBL	Inhibition of human carbonic anhydrase 6 by stopped-flow CO2 hydration assay	B	4.92	pKi	11900	nM	Ki	Bioorg. Med. Chem. (2008) 16: 7424-7428 [PMID:18579385]
carbonic anhydrase 7/Carbonic anhydrase VII in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2326] [GtoPdb: 2749] [UniProtKB: P43166]
ChEMBL	Inhibition of human carbonic anhydrase 7 by stopped-flow CO2 hydration assay	B	4.09	pKi	82100	nM	Ki	Bioorg. Med. Chem. (2008) 16: 7424-7428 [PMID:18579385]
carbonic anhydrase 12/Carbonic anhydrase XII in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3242] [GtoPdb: 2747] [UniProtKB: O43570]
ChEMBL	Inhibition of human carbonic anhydrase 12 catalytic domain by stopped-flow CO2 hydration assay	B	5.06	pKi	8800	nM	Ki	Bioorg. Med. Chem. (2008) 16: 7424-7428 [PMID:18579385]
carbonic anhydrase 13/Carbonic anhydrase XIII in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2186] [GtoPdb: 2748] [UniProtKB: Q9D6N1]
ChEMBL	Inhibition of mouse carbonic anhydrase 13 by stopped-flow CO2 hydration assay	B	4.17	pKi	67000	nM	Ki	Bioorg. Med. Chem. (2008) 16: 7424-7428 [PMID:18579385]
carbonic anhydrase 14/Carbonic anhydrase XIV in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3510] [GtoPdb: 2598] [UniProtKB: Q9ULX7]
ChEMBL	Inhibition of human carbonic anhydrase 14 by stopped-flow CO2 hydration assay	B	4.3	pKi	49800	nM	Ki	Bioorg. Med. Chem. (2008) 16: 7424-7428 [PMID:18579385]
High mobility group protein B1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2311236] [UniProtKB: P09429]
ChEMBL	Binding affinity to recombinant HMGB1 box A (unknown origin)	B	6	pKd	1000	nM	Kd	J Med Chem (2018) 61: 5093-5107 [PMID:29268019]
ChEMBL	Binding affinity to recombinant HMGB1 box B (unknown origin)	B	6	pKd	1000	nM	Kd	J Med Chem (2018) 61: 5093-5107 [PMID:29268019]
OAT6/Solute carrier family 22 member 20 in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5269] [GtoPdb: 1037] [UniProtKB: Q80UJ1]
ChEMBL	Inhibition of mouse Oat6-mediated [3H]ES uptake in Xenopus oocytes after 1 hr	B	4.36	pKi	44000	nM	Ki	J. Biol. Chem. (2007) 282: 23841-23853 [PMID:17553798]
ChEMBL	Inhibition of mouse Oat6-mediated [3H]ES uptake in Xenopus oocytes after 1 hr	B	4.36	pKi	43651.58	nM	Ki	J. Biol. Chem. (2007) 282: 23841-23853 [PMID:17553798]
Tyrosinase in Agaricus bisporus (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3318] [UniProtKB: O42713]
ChEMBL	Inhibition of mushroom tyrosinase after 10 mins	B	4	pIC50	100000	nM	IC50	J. Med. Chem. (2011) 54: 591-602 [PMID:21189019]
ASIC3 in Human [GtoPdb: 686] [UniProtKB: Q9UHC3]
GtoPdb	-	-	3.6	pIC50	260000	nM	IC50	J. Neurosci. (2001) 21: 8026-33 [PMID:11588175]

ChEMBL data shown on this page come from version 27:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, Cibrián-Uhalte E, Davies M, Dedman N, Karlsson A, Magariños MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]