NS1619 [Ligand Id: 4272] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL384903 (NS-1619) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| KCa1.1/Calcium-activated potassium channel subunit alpha-1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4304] [GtoPdb: 380] [UniProtKB: Q12791] | ||||||||
| ChEMBL | Activation of BK channel-mediated vasorelaxation activity assessed as reduction in KCl-induced contractile tone | B | 5.23 | pIC50 | 5888.44 | nM | IC50 | Bioorg Med Chem (2009) 17: 319-325 [PMID:19026552] |
| KCa1.1/Calcium-activated potassium channel subunit alpha-1 in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5505] [GtoPdb: 380] [UniProtKB: Q62976] | ||||||||
| ChEMBL | Activation of BK channel in Wistar rat thoracic aorta assessed as relaxation of KCl-induced contraction | B | 5.29 | pIC50 | 5128.61 | nM | IC50 | Eur J Med Chem (2008) 43: 2618-2626 [PMID:18400336] |
| ChEMBL | Activation of large-conductance calcium-activated potassium channel-mediated vasorelaxation in endothelium-denuded normotensive Wistar rat thoracic aorta assessed as potassium chloride-induced contractile tension | B | 5.3 | pIC50 | 5011.87 | nM | IC50 | J Med Chem (2008) 51: 5085-5092 [PMID:18680269] |
| ChEMBL | Induction of BK channel mediated vasorelaxation activity in Kcl-induced contraction in Wistar rat aorta | B | 5.36 | pIC50 | 4365.16 | nM | IC50 | Eur J Med Chem (2008) 43: 792-799 [PMID:17692999] |
| heat shock protein 90 alpha family class A member 1/Heat shock protein HSP 90-alpha in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3880] [GtoPdb: 2905] [UniProtKB: P07900] | ||||||||
| ChEMBL | Inhibition of Hsp90alpha ATPase activity by malachite green ATP-ase assay | B | 4.09 | pIC50 | 81000 | nM | IC50 | Bioorg Med Chem Lett (2010) 20: 7503-7506 [PMID:21106457] |
| ChEMBL | Binding affinity to Hsp90alpha N-terminal ATPase domain by TR-FRET assay based competitive binding assay | B | 5.48 | pIC50 | 3320 | nM | IC50 | Bioorg Med Chem Lett (2010) 20: 7503-7506 [PMID:21106457] |
| Plasmodium falciparum (target type: ORGANISM) [ChEMBL: CHEMBL364] | ||||||||
| ChEMBL | Antiplasmodial activity against Plasmodium falciparum 3D7 after 72 hrs by SYBR green assay | F | 4.8 | pIC50 | 15848.93 | nM | IC50 | Nat Chem Biol (2009) 5: 765-771 [PMID:19734910] |
| ChEMBL | Antiplasmodial activity against Plasmodium falciparum Dd2 after 72 hrs by SYBR green assay | F | 4.9 | pIC50 | 12589.25 | nM | IC50 | Nat Chem Biol (2009) 5: 765-771 [PMID:19734910] |
| ChEMBL | Antiplasmodial activity against Plasmodium falciparum D10 after 72 hrs by SYBR green assay | F | 5 | pIC50 | 10000 | nM | IC50 | Nat Chem Biol (2009) 5: 765-771 [PMID:19734910] |
| ChEMBL | Antiplasmodial activity against Plasmodium falciparum HB3 after 72 hrs by SYBR green assay | F | 5 | pIC50 | 10000 | nM | IC50 | Nat Chem Biol (2009) 5: 765-771 [PMID:19734910] |
| ChEMBL | Antiplasmodial activity against Plasmodium falciparum W2 after 72 hrs by SYBR green assay | F | 5.1 | pIC50 | 7943.28 | nM | IC50 | Nat Chem Biol (2009) 5: 765-771 [PMID:19734910] |
| ChEMBL | Antiplasmodial activity against Plasmodium falciparum 7G8 after 72 hrs by SYBR green assay | F | 5.4 | pIC50 | 3981.07 | nM | IC50 | Nat Chem Biol (2009) 5: 765-771 [PMID:19734910] |
| ChEMBL | Antiplasmodial activity against Plasmodium falciparum GB4 after 72 hrs by SYBR green assay | F | 5.4 | pIC50 | 3981.07 | nM | IC50 | Nat Chem Biol (2009) 5: 765-771 [PMID:19734910] |
ChEMBL data shown on this page come from version 34:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
