NS1619 [Ligand Id: 4272] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL384903 (NS-1619) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| KCa1.1/Calcium-activated potassium channel subunit alpha-1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4304] [GtoPdb: 380] [UniProtKB: Q12791] | ||||||||
| ChEMBL | Activation of BK channel-mediated vasorelaxation activity assessed as reduction in KCl-induced contractile tone | B | 5.23 | pIC50 | 5888.44 | nM | IC50 | Bioorg Med Chem (2009) 17: 319-325 [PMID:19026552] |
| KCa1.1/Calcium-activated potassium channel subunit alpha-1 in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5505] [GtoPdb: 380] [UniProtKB: Q62976] | ||||||||
| ChEMBL | Activation of BK channel in Wistar rat thoracic aorta assessed as relaxation of KCl-induced contraction | B | 5.29 | pIC50 | 5128.61 | nM | IC50 | Eur J Med Chem (2008) 43: 2618-2626 [PMID:18400336] |
| ChEMBL | Activation of large-conductance calcium-activated potassium channel-mediated vasorelaxation in endothelium-denuded normotensive Wistar rat thoracic aorta assessed as potassium chloride-induced contractile tension | B | 5.3 | pIC50 | 5011.87 | nM | IC50 | J Med Chem (2008) 51: 5085-5092 [PMID:18680269] |
| ChEMBL | Induction of BK channel mediated vasorelaxation activity in Kcl-induced contraction in Wistar rat aorta | B | 5.36 | pIC50 | 4365.16 | nM | IC50 | Eur J Med Chem (2008) 43: 792-799 [PMID:17692999] |
| heat shock protein 90 alpha family class A member 1/Heat shock protein HSP 90-alpha in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3880] [GtoPdb: 2905] [UniProtKB: P07900] | ||||||||
| ChEMBL | Inhibition of Hsp90alpha ATPase activity by malachite green ATP-ase assay | B | 4.09 | pIC50 | 81000 | nM | IC50 | Bioorg Med Chem Lett (2010) 20: 7503-7506 [PMID:21106457] |
| ChEMBL | Binding affinity to Hsp90alpha N-terminal ATPase domain by TR-FRET assay based competitive binding assay | B | 5.48 | pIC50 | 3320 | nM | IC50 | Bioorg Med Chem Lett (2010) 20: 7503-7506 [PMID:21106457] |
| Plasmodium falciparum (target type: ORGANISM) [ChEMBL: CHEMBL364] | ||||||||
| ChEMBL | Antiplasmodial activity against Plasmodium falciparum 3D7 after 72 hrs by SYBR green assay | F | 4.8 | pIC50 | 15848.93 | nM | IC50 | Nat Chem Biol (2009) 5: 765-771 [PMID:19734910] |
| ChEMBL | Antiplasmodial activity against Plasmodium falciparum Dd2 after 72 hrs by SYBR green assay | F | 4.9 | pIC50 | 12589.25 | nM | IC50 | Nat Chem Biol (2009) 5: 765-771 [PMID:19734910] |
| ChEMBL | Antiplasmodial activity against Plasmodium falciparum D10 after 72 hrs by SYBR green assay | F | 5 | pIC50 | 10000 | nM | IC50 | Nat Chem Biol (2009) 5: 765-771 [PMID:19734910] |
| ChEMBL | Antiplasmodial activity against Plasmodium falciparum HB3 after 72 hrs by SYBR green assay | F | 5 | pIC50 | 10000 | nM | IC50 | Nat Chem Biol (2009) 5: 765-771 [PMID:19734910] |
| ChEMBL | Antiplasmodial activity against Plasmodium falciparum W2 after 72 hrs by SYBR green assay | F | 5.1 | pIC50 | 7943.28 | nM | IC50 | Nat Chem Biol (2009) 5: 765-771 [PMID:19734910] |
| ChEMBL | Antiplasmodial activity against Plasmodium falciparum 7G8 after 72 hrs by SYBR green assay | F | 5.4 | pIC50 | 3981.07 | nM | IC50 | Nat Chem Biol (2009) 5: 765-771 [PMID:19734910] |
| ChEMBL | Antiplasmodial activity against Plasmodium falciparum GB4 after 72 hrs by SYBR green assay | F | 5.4 | pIC50 | 3981.07 | nM | IC50 | Nat Chem Biol (2009) 5: 765-771 [PMID:19734910] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
