sakuranetin [Ligand Id: 412] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL448297 (7-O-Methylnaringenin, Naringenin 7-Methyl Ether, Sakuranetin) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| Inducible NOS/Nitric oxide synthase, inducible in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3464] [GtoPdb: 1250] [UniProtKB: P29477] | ||||||||
| ChEMBL | Inhibition of iNOS-mediated NO production in LPS-stimulated mouse RAW264.7 cells after 24 hrs by Griess reagent method | B | 4.71 | pIC50 | 19550 | nM | IC50 | J Nat Prod (2011) 74: 2489-2496 [PMID:22148193] |
| TAS2R31/Taste receptor type 2 member 31 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2034804] [GtoPdb: 674] [UniProtKB: P59538] | ||||||||
| GtoPdb | - | - | 5.26 | pIC50 | 5500 | nM | IC50 | J Agric Food Chem (2011) 59: 13117-21 [PMID:22059530] |
| ChEMBL | Inhibition of human TAS2R31 receptor expressed in HEK293T cells overexpressing chimeric G-protein alpha-subunit | B | 5.44 | pIC50 | 3600 | nM | IC50 | J Nat Prod (2011) 74: 1539-1555 [PMID:21650152] |
| A1 receptor in Rat [GtoPdb: 18] [UniProtKB: P25099] | ||||||||
| GtoPdb | - | - | 5.1 | pKi | - | - | - | J Med Chem (1996) 39: 2293-301 [PMID:8691424] |
| A2A receptor in Human [GtoPdb: 19] [UniProtKB: P29274] | ||||||||
| GtoPdb | - | - | 4.4 | pKi | - | - | - | J Med Chem (1996) 39: 2293-301 [PMID:8691424] |
| A3 receptor in Human [GtoPdb: 21] [UniProtKB: P0DMS8] | ||||||||
| GtoPdb | - | - | 5.5 | pKi | - | - | - | J Med Chem (1996) 39: 2293-301 [PMID:8691424] |
ChEMBL data shown on this page come from version 34:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
