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ChEMBL ligand: CHEMBL11 (Antideprin, Berkomine, Cristalia, Imipramine, Janimine, Melipramine, NSC-169866, ORG-2463, Pramine, Presamine, Sermonil, Tofranil, Tofranil-PM, Trimipramine maleate impurity, imipramine-) |
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DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
---|---|---|---|---|---|---|---|---|
α1A-adrenoceptor/Alpha-1a adrenergic receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL319] [GtoPdb: 22] [UniProtKB: P43140] | ||||||||
ChEMBL | Inhibition of binding of [3H]imipramine to imipramine receptor in rat brain | B | 8.77 | pIC50 | 1.7 | nM | IC50 | J Med Chem (1990) 33: 2899-2905 [PMID:1976813] |
D2 receptor/Dopamine D2 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL217] [GtoPdb: 215] [UniProtKB: P14416] | ||||||||
ChEMBL | Binding affinity towards dopamine receptor D2 using [3H]spiperone as radioligand | B | 6.14 | pKi | 726 | nM | Ki | Bioorg Med Chem Lett (2004) 14: 2279-2283 [PMID:15081025] |
ChEMBL | Binding affinity to dopamine D2 receptor (unknown origin) by radioligand binding assay | B | 6.39 | pIC50 | 410 | nM | IC50 | J Med Chem (2013) 56: 8955-8971 [PMID:23919353] |
D2 receptor/Dopamine D2 receptor in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3427] [GtoPdb: 215] [UniProtKB: P61168] | ||||||||
ChEMBL | Binding affinity to Dopamine receptor D2 using [3H]spiperone as radioligand in stably transfected NIH3T3 cells | B | 6.14 | pKi | 726 | nM | Ki | Bioorg Med Chem Lett (2001) 11: 655-658 [PMID:11266163] |
DAT/Dopamine transporter in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL238] [GtoPdb: 927] [UniProtKB: Q01959] | ||||||||
ChEMBL | Inhibition of [3H]dopamine uptake at human DAT expressed in HEK293 cells | B | 4.59 | pIC50 | 25600 | nM | IC50 | Antimicrob Agents Chemother (2007) 51: 4133-4140 [PMID:17846138] |
DAT/Dopamine transporter in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2799] [GtoPdb: 927] [UniProtKB: Q61327] | ||||||||
ChEMBL | Tested in vitro for dopamine(DA) neuronal uptake inhibition | B | 5 | pKi | >10000 | nM | Ki | J Med Chem (1990) 33: 2793-2797 [PMID:2213832] |
DAT/Dopamine transporter in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL338] [GtoPdb: 927] [UniProtKB: P23977] | ||||||||
ChEMBL | Inhibition of the uptake of tritiated dopamine (DA) in rat synaptosomes | B | 5 | pKi | >10000 | nM | Ki | J Med Chem (1987) 30: 1433-1454 [PMID:3039136] |
ChEMBL | Inhibition of dopamine uptake in synaptosomal preparation in rat corpus striatum, using [3H]dopamine | F | 4.7 | pIC50 | 20000 | nM | IC50 | J Med Chem (1984) 27: 1508-1515 [PMID:6492080] |
GluN1/GluN2A/GluN2B/GluN2C/GluN2D/GluN3B/GluN3A/Glutamate NMDA receptor in Rat (target type: PROTEIN COMPLEX GROUP) [ChEMBL: CHEMBL1907608] [GtoPdb: 455, 456, 457, 458, 459, 461, 460] [UniProtKB: P35439, Q00959, Q00960, Q00961, Q62645, Q8VHN2, Q9R1M7] | ||||||||
ChEMBL | Inhibition of [3H]MK-801 binding to NMDA receptor of rat cerebral cortical synaptic membrane | B | 4.85 | pIC50 | 14000 | nM | IC50 | J Med Chem (1995) 38: 2964-2968 [PMID:7636857] |
Kv11.1/HERG in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL240] [GtoPdb: 572] [UniProtKB: Q12809] | ||||||||
ChEMBL | K+ channel blocking activity in Chinese hamster ovary cells expressing HERG Kv11.1 | F | 5.47 | pIC50 | 3400 | nM | IC50 | J Med Chem (2002) 45: 3844-3853 [PMID:12190308] |
ChEMBL | Inhibition of hERG K channel | F | 5.47 | pIC50 | 3400 | nM | IC50 | Cardiovasc Res (2011) 91: 53-61 [PMID:21300721] |
ChEMBL | Inhibition of partially open human voltage-gated potassium channel subunit Kv11.1 (ERG K+ channel) | F | 5.47 | pIC50 | 3388.44 | nM | IC50 | Bioorg Med Chem Lett (2005) 15: 1737-1741 [PMID:15745831] |
ChEMBL | Inhibitory concentration against potassium channel HERG | B | 5.47 | pIC50 | 3388.44 | nM | IC50 | Bioorg Med Chem Lett (2005) 15: 2886-2890 [PMID:15911273] |
ChEMBL | Inhibition of human ERG expressed in CHO cells by whole cell patch clamp technique | B | 5.47 | pIC50 | 3388.44 | nM | IC50 | Bioorg Med Chem (2008) 16: 6252-6260 [PMID:18448342] |
ChEMBL | Inhibition of human ERG in MCF7 cells | B | 5.47 | pIC50 | 3388.44 | nM | IC50 | Eur J Med Chem (2009) 44: 1926-1932 [PMID:19110341] |
ChEMBL | Inhibition of human ERG | B | 5.47 | pIC50 | 3388.44 | nM | IC50 | Eur J Med Chem (2011) 46: 618-630 [PMID:21185626] |
ChEMBL | Inhibition of human Potassium channel HERG expressed in mammalian cells | B | 5.47 | pIC50 | 3388.44 | nM | IC50 | Bioorg Med Chem Lett (2003) 13: 2773-2775 [PMID:12873512] |
H1 receptor/Histamine H1 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL231] [GtoPdb: 262] [UniProtKB: P35367] | ||||||||
ChEMBL | Binding affinity to H1 receptor (unknown origin) | B | 8 | pKi | 10 | nM | Ki | Bioorg Med Chem Lett (2020) 30: 127493-127493 [PMID:32798652] |
ChEMBL | Binding affinity to histamine H1 receptor (unknown origin) by radioligand binding assay | B | 7.57 | pIC50 | 27 | nM | IC50 | J Med Chem (2013) 56: 8955-8971 [PMID:23919353] |
H1 receptor/Histamine H1 receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4701] [GtoPdb: 262] [UniProtKB: P31390] | ||||||||
ChEMBL | Compound tested for its inhibitory activity against Histamine H1 receptor | B | 10.22 | pIC50 | 0.06 | nM | IC50 | J Med Chem (1999) 42: 3154-3162 [PMID:10447960] |
Histamine H2 receptor in Guinea pig (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2882] [UniProtKB: P47747] | ||||||||
ChEMBL | Inhibitory activity against brain adenylate cyclase Histamine H2 receptor | F | 5.72 | pIC50 | 1900 | nM | IC50 | J Med Chem (1999) 42: 3154-3162 [PMID:10447960] |
M5 receptor/Muscarinic acetylcholine receptor M5 in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL277] [GtoPdb: 17] [UniProtKB: P08911] | ||||||||
ChEMBL | Binding affinity towards muscarinic acetylcholine receptor by inhibiting specific binding of [3H]quinuclidinyl benzilate (0.8 nM) in vitro to membranes of rat brain without cerebellum | B | 6.52 | pIC50 | 300 | nM | IC50 | J Med Chem (1984) 27: 995-1003 [PMID:6747997] |
NET/Norepinephrine transporter in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL222] [GtoPdb: 926] [UniProtKB: P23975] | ||||||||
ChEMBL | Binding affinity towards Norepinephrine transporter using [3H]nisoxitine as radioligand | B | 7.8 | pKi | 16 | nM | Ki | Bioorg Med Chem Lett (2004) 14: 2279-2283 [PMID:15081025] |
GtoPdb | - | - | 7.8 | pKi | 16 | nM | Ki | |
ChEMBL | Inhibition of [3H]norepinephrine uptake at human NET expressed in HEK293 cells | B | 7.13 | pIC50 | 74 | nM | IC50 | Antimicrob Agents Chemother (2007) 51: 4133-4140 [PMID:17846138] |
NET/Norepinephrine transporter in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2370] [GtoPdb: 926] [UniProtKB: O55192] | ||||||||
ChEMBL | Binding affinity to Norepinephrine transporter using [3H]-nisoxatine as radioligand in stably transfected NIH3T3 cells | B | 7.8 | pKi | 16 | nM | Ki | Bioorg Med Chem Lett (2001) 11: 655-658 [PMID:11266163] |
ChEMBL | Tested in vitro for norepinephrine (NE) neuronal uptake inhibition | B | 7.92 | pKi | 12 | nM | Ki | J Med Chem (1990) 33: 2793-2797 [PMID:2213832] |
Norepinephrine transporter in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL304] [UniProtKB: Q9WTR4] | ||||||||
ChEMBL | Inhibition of uptake of tritiated norepinephrine (NE) in rat synaptosomes | B | 7.92 | pKi | 12 | nM | Ki | J Med Chem (1987) 30: 1433-1454 [PMID:3039136] |
ChEMBL | In vitro inhibition of accumulation of (-)-[3H]Norepinephrine (NA) in mouse brain slices | F | 5.89 | pIC50 | 1300 | nM | IC50 | J Med Chem (1981) 24: 1499-1507 [PMID:6458703] |
ChEMBL | Inhibition of uptake of tritiated norepinephrine (NE) into rat brain synaptosomes | F | 6.59 | pIC50 | 260 | nM | IC50 | J Med Chem (1990) 33: 2899-2905 [PMID:1976813] |
ChEMBL | Inhibition of norepinephrine uptake in synaptosomal preparation fro rat hypothalamus, using [3H]norepinephrine | F | 7.22 | pIC50 | 60 | nM | IC50 | J Med Chem (1984) 27: 1508-1515 [PMID:6492080] |
Pleiotropic ABC efflux transporter of multiple drugs in Saccharomyces cerevisiae S288c (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1697658] [UniProtKB: P33302] | ||||||||
ChEMBL | Inhibition of Pdr5p-mediated rhodamine 6G transport in Saccharomyces cerevisiae MKPDR5h plasma membrane by spectrofluorometric assay | B | 4.66 | pIC50 | 22000 | nM | IC50 | Antimicrob Agents Chemother (2009) 53: 1516-1527 [PMID:19188399] |
Prion protein in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4869] [UniProtKB: P04156] | ||||||||
ChEMBL | Half maximal inhibition of Prion protein PrPsc formation was assayed in ScN2a cells | B | 5 | pEC50 | 10000 | nM | EC50 | J Med Chem (2003) 46: 3563-3564 [PMID:12904059] |
5-HT2A receptor/Serotonin 2a (5-HT2a) receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL224] [GtoPdb: 6] [UniProtKB: P28223] | ||||||||
ChEMBL | Displacement of [3H]ketanserin from 5-hydroxytryptamine 2A receptor expressed NIH3T3 cells | B | 6.8 | pKi | 160 | nM | Ki | Bioorg Med Chem Lett (2001) 11: 655-658 [PMID:11266163] |
ChEMBL | Binding affinity towards 5-hydroxytryptamine 2A receptor using [3H]ketanserin | B | 7.03 | pKi | 94 | nM | Ki | Bioorg Med Chem Lett (2004) 14: 2279-2283 [PMID:15081025] |
ChEMBL | Binding affinity to 5HT2A receptor (unknown origin) by radioligand binding assay | B | 6.66 | pIC50 | 220 | nM | IC50 | J Med Chem (2013) 56: 8955-8971 [PMID:23919353] |
5-HT2C receptor/Serotonin 2c (5-HT2c) receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL225] [GtoPdb: 8] [UniProtKB: P28335] | ||||||||
ChEMBL | Binding affinity towards 5-hydroxytryptamine 2C receptor using [3H]mesulergine as radioligand | B | 6.8 | pKi | 160 | nM | Ki | Bioorg Med Chem Lett (2004) 14: 2279-2283 [PMID:15081025] |
5-HT2C receptor/Serotonin 2c (5-HT2c) receptor in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3006] [GtoPdb: 8] [UniProtKB: P34968] | ||||||||
ChEMBL | Binding affinity to 5-hydroxytryptamine 2C receptor using [3H]Mesulergine as radioligand in stably transfected NIH3T3 cells | B | 6.8 | pKi | 160 | nM | Ki | Bioorg Med Chem Lett (2001) 11: 655-658 [PMID:11266163] |
SERT/Serotonin transporter in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL228] [GtoPdb: 928] [UniProtKB: P31645] | ||||||||
ChEMBL | Inhibition of human SERT I172M mutant expressed in HEK293 MSR cells assessed as [3H]-5-HT uptake preincubated for 30 mins followed addition of [3H]-5HT and compound for 10 mins by micro-scintillation counter | B | 5.89 | pKi | 1300 | nM | Ki | Bioorg Med Chem (2016) 24: 2725-2738 [PMID:27160055] |
ChEMBL | Inhibition of wild-type human SERT expressed in HEK293 MSR cells assessed as [3H]-5-HT uptake preincubated for 30 mins followed addition of [3H]-5HT and compound for 10 mins by micro-scintillation counter | B | 7.51 | pKi | 31 | nM | Ki | Bioorg Med Chem (2016) 24: 2725-2738 [PMID:27160055] |
GtoPdb | Displacement of [3H]citalopram from hSERT. | - | 7.69 | pKi | 20.3 | nM | Ki | J Nat Prod (1993) 56: 441-55 [PMID:8496700] |
ChEMBL | Displacement of [3H]citalopram from serotonin transporter | B | 7.69 | pKi | 20.3 | nM | Ki | J Nat Prod (1993) 56: 441-455 [PMID:8496700] |
ChEMBL | Binding affinity to SERT (unknown origin) | B | 7.7 | pKi | 20 | nM | Ki | Bioorg Med Chem Lett (2020) 30: 127493-127493 [PMID:32798652] |
ChEMBL | Inhibition of [3H]serotonin reuptake at serotonin transporter | B | 8.12 | pKi | 7.57 | nM | Ki | J Med Chem (2009) 52: 5872-5879 [PMID:19791802] |
ChEMBL | Inhibition of human SERT I179C mutant expressed in HEK293 MSR cells assessed as [3H]-5-HT uptake preincubated for 30 mins followed addition of [3H]-5HT and compound for 10 mins by micro-scintillation counter | B | 8.24 | pKi | 5.7 | nM | Ki | Bioorg Med Chem (2016) 24: 2725-2738 [PMID:27160055] |
ChEMBL | Binding affinity towards Serotonin transporter using [3H]paroxetine as radioligand | B | 8.3 | pKi | 5 | nM | Ki | Bioorg Med Chem Lett (2004) 14: 2279-2283 [PMID:15081025] |
ChEMBL | Displacement of radiolabeled imipramine from human SERT | B | 8.49 | pKi | 3.2 | nM | Ki | J Med Chem (2008) 51: 7094-7098 [PMID:18983139] |
ChEMBL | Displacement of [3H]-imipramine from human serotonin transporter expressed in HEK293 cells membranes incubated for 30 mins by microbeta scintillation counting analysis | B | 8.6 | pKi | 2.5 | nM | Ki | Eur J Med Chem (2019) 183: 111736-111736 [PMID:31586817] |
ChEMBL | Displacement of [3H]imipramine from human recombinant SERT expressed in CHO cells | B | 8.68 | pKi | 2.1 | nM | Ki | J Med Chem (2014) 57: 4543-4557 [PMID:24805037] |
ChEMBL | Displacement of [3H]imipramine from human SERT expressed in CHO cells | B | 8.68 | pKi | 2.1 | nM | Ki | Eur J Med Chem (2015) 92: 221-235 [PMID:25557493] |
ChEMBL | Displacement of [3H]citalopram from human SERT expressed in HEK293 cell membranes after 1 hr by liquid scintillation counting method | B | 8.7 | pKi | 2 | nM | Ki | Bioorg Med Chem (2017) 25: 293-304 [PMID:27865645] |
ChEMBL | Displacement of [3H] imipramine from human recombinant 5-HT transporter measured after 60 mins by scintillation counter method | B | 8.72 | pKi | 1.9 | nM | Ki | Eur J Med Chem (2019) 176: 292-309 [PMID:31112891] |
ChEMBL | Displacement of [3H]-imipramine from human serotonin transporter expressed in HEK-293 cell membranes after 30 mins by scintillation counting | B | 9 | pKi | 1 | nM | Ki | J Med Chem (2017) 60: 7483-7501 [PMID:28763213] |
ChEMBL | Displacement of [3H]imipramine from human 5HT transporter | B | 9.11 | pKi | 0.77 | nM | Ki | J Med Chem (2011) 54: 5320-5334 [PMID:21726069] |
ChEMBL | Binding affinity to human 5-HT transporter by radioligand displacement assay | B | 9.28 | pKi | 0.52 | nM | Ki | Eur J Med Chem (2013) 63: 85-94 [PMID:23466604] |
ChEMBL | Inhibition of SERT (unknown origin) | B | 7.54 | pIC50 | 29 | nM | IC50 | J Med Chem (2020) 63: 15187-15217 [PMID:33111525] |
ChEMBL | Inhibition of human SERT expressed in HEK293-MSR cells by 5-HT uptake assay | B | 7.54 | pIC50 | 29 | nM | IC50 | Bioorg Med Chem Lett (2013) 23: 1220-1224 [PMID:23385211] |
ChEMBL | Inhibition of [3H]5HT uptake at human SERT expressed in HEK293 cells | B | 8.1 | pIC50 | 8 | nM | IC50 | Antimicrob Agents Chemother (2007) 51: 4133-4140 [PMID:17846138] |
ChEMBL | Inhibition of human 5-HT transporter | B | 8.14 | pIC50 | 7.3 | nM | IC50 | Bioorg Med Chem (2010) 18: 7675-7699 [PMID:20875743] |
ChEMBL | Displacement of radiolabeled imipramine from human SERT | B | 8.16 | pIC50 | 6.9 | nM | IC50 | J Med Chem (2008) 51: 7094-7098 [PMID:18983139] |
ChEMBL | Displacement of [3H]imipramin from human recombinant SERT over-expressed in HEK293 cells | B | 8.17 | pIC50 | 6.8 | nM | IC50 | Bioorg Med Chem Lett (2013) 23: 5515-5518 [PMID:24012181] |
ChEMBL | Inhibition of human SERT expressed in CHO cell membranes assessed as reduction in [3H]serotonin uptake preincubated for 10 mins followed by [3H]serotonin addition measured after 20 mins by liquid scintillation counting method | B | 8.29 | pIC50 | 5.1 | nM | IC50 | Bioorg Med Chem (2017) 25: 293-304 [PMID:27865645] |
ChEMBL | Percent inhibition against 5-hydroxytryptamine transporter at 1 uM nonselective | B | 8.36 | pIC50 | 4.4 | nM | IC50 | J Med Chem (2005) 48: 6887-6896 [PMID:16250647] |
ChEMBL | Displacement of [3H] imipramine from human recombinant 5-HT transporter measured after 60 mins by scintillation counter method | B | 8.39 | pIC50 | 4.1 | nM | IC50 | Eur J Med Chem (2019) 176: 292-309 [PMID:31112891] |
ChEMBL | Binding affinity to SERT (unknown origin) by radioligand binding assay | B | 8.46 | pIC50 | 3.5 | nM | IC50 | J Med Chem (2013) 56: 8955-8971 [PMID:23919353] |
ChEMBL | Inhibition of human SERT W103A mutant expressed in HEK293 MSR cells assessed as [3H]-5-HT uptake preincubated for 30 mins followed addition of [3H]-5HT and compound for 10 mins by micro-scintillation counter | B | 8.59 | pIC50 | 2.6 | nM | IC50 | Bioorg Med Chem (2016) 24: 2725-2738 [PMID:27160055] |
ChEMBL | Binding affinity to human serotonin 5-HT transporter by radioligand displacement assay | B | 8.7 | pIC50 | 2 | nM | IC50 | Bioorg Med Chem (2013) 21: 2764-2771 [PMID:23582449] |
ChEMBL | Binding affinity to human 5-HT transporter by radioligand displacement assay | B | 8.96 | pIC50 | 1.1 | nM | IC50 | Eur J Med Chem (2013) 63: 85-94 [PMID:23466604] |
ChEMBL | Displacement of [3H]imipramine from human recombinant 5HT transporter expressed in CHO cells measured after 60 mins by scintillation counting method | B | 9.06 | pIC50 | 0.88 | nM | IC50 | Bioorg Med Chem (2017) 25: 471-482 [PMID:27876250] |
ChEMBL | Displacement of [3H]imipramine from human recombinant 5-HT transporter expressed in CHO cells | B | 9.06 | pIC50 | 0.88 | nM | IC50 | Bioorg Med Chem (2016) 24: 1793-1810 [PMID:26988801] |
SERT/Serotonin transporter in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4642] [GtoPdb: 928] [UniProtKB: Q60857] | ||||||||
ChEMBL | Tested in vitro for serotonin(5-HT) neuronal uptake inhibition | B | 7.38 | pKi | 42 | nM | Ki | J Med Chem (1990) 33: 2793-2797 [PMID:2213832] |
ChEMBL | Binding affinity to Serotonin transporter using [3H]-paroxetine as radioligand in stably transfected NIH3T3 cells | B | 8.3 | pKi | 5 | nM | Ki | Bioorg Med Chem Lett (2001) 11: 655-658 [PMID:11266163] |
SERT/Serotonin transporter in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL313] [GtoPdb: 928] [UniProtKB: P31652] | ||||||||
ChEMBL | Inhibition the uptake of tritiated serotonin (5-HT) by the serotonin transporter SERT in rat synaptosomes | B | 7.38 | pKi | 41.8 | nM | Ki | J Med Chem (1987) 30: 1433-1454 [PMID:3039136] |
ChEMBL | Displacement of [3H]-citalopram from SERT in rat cortex tissue incubated for 60 mins by microbeta scintillation counting method | B | 7.54 | pKi | 29 | nM | Ki | Eur J Med Chem (2019) 180: 383-397 [PMID:31325785] |
ChEMBL | Displacement of [3H]-citalopram from SERT in rat cortex tissue measured after 60 mins by microbeta scintillation counting analysis | B | 7.54 | pKi | 29 | nM | Ki | Eur J Med Chem (2019) 166: 144-158 [PMID:30703658] |
ChEMBL | Inhibition of 5-HT uptake in synaptosomal preparation from rat corpus striatum, using [3H]5-HT | F | 6.09 | pIC50 | 810 | nM | IC50 | J Med Chem (1984) 27: 1508-1515 [PMID:6492080] |
ChEMBL | In vitro inhibition of accumulation of [14C]5-HT (5-HT) in mouse brain slices | F | 6.52 | pIC50 | 300 | nM | IC50 | J Med Chem (1981) 24: 1499-1507 [PMID:6458703] |
ChEMBL | Inhibition of uptake of tritiated serotonin (5-HT) into rat brain synaptosomes | F | 6.92 | pIC50 | 120 | nM | IC50 | J Med Chem (1990) 33: 2899-2905 [PMID:1976813] |
ChEMBL | Inhibition of SERT expressed in rat brain synaptosomes assessed as decrease in incorporation of [3H]serotonin measured after 15 mins by scintillation counting method | B | 7.21 | pIC50 | 61 | nM | IC50 | J Med Chem (2017) 60: 7483-7501 [PMID:28763213] |
σ2/Sigma intracellular receptor 2 in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4105864] [GtoPdb: 2553] [UniProtKB: Q5U3Y7] | ||||||||
ChEMBL | Displacement of [3H]DTG from sigma 2 receptor in Sprague-Dawley rat brain membranes in presence of (+)-pentazocine by scintillation counting method | B | 5.68 | pKi | 2107 | nM | Ki | J Med Chem (2020) 63: 15187-15217 [PMID:33111525] |
sigma non-opioid intracellular receptor 1/Sigma opioid receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3602] [GtoPdb: 2552] [UniProtKB: Q9R0C9] | ||||||||
ChEMBL | Displacement of [3H]-(+)-pentazocine from sigma 1 receptor in Sprague-Dawley rat brain membranes by scintillation counting method | B | 6.46 | pKi | 343 | nM | Ki | J Med Chem (2020) 63: 15187-15217 [PMID:33111525] |
Organic cation transporter 1/Solute carrier family 22 member 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5685] [GtoPdb: 1019] [UniProtKB: O15245] | ||||||||
ChEMBL | Inhibition of 4-(4-(dimethylamino)styryl)-N-methylpyridinium uptake at human OCT1 expressed in HEK293 cells by confocal microscopy | B | 4.77 | pIC50 | 17100 | nM | IC50 | J Med Chem (2008) 51: 5932-5942 [PMID:18788725] |
ChEMBL | Inhibition of human OCT1 expressed in HEK293 cells assessed as decrease in uptake of ASP+ after 2 mins by fluorescence assay | B | 5.1 | pIC50 | 7950 | nM | IC50 | J Med Chem (2017) 60: 2685-2696 [PMID:28230985] |
Organic cation transporter 1/Solute carrier family 22 member 1 in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2073670] [GtoPdb: 1019] [UniProtKB: Q63089] | ||||||||
ChEMBL | TP_TRANSPORTER: inhibition of TEA uptake (TEA: 50 uM) in OCT1-expressing MDCK cells | F | 4.8 | pIC50 | 16000 | nM | IC50 | Pharm Res (2001) 18: 1528-1534 [PMID:11758759] |
Organic cation transporter 2/Solute carrier family 22 member 2 in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1770032] [GtoPdb: 1020] [UniProtKB: Q9R0W2] | ||||||||
ChEMBL | TP_TRANSPORTER: inhibition of TEA uptake (TEA: 50 uM) in OCT2-expressing MDCK cells | F | 5 | pIC50 | 9900 | nM | IC50 | Pharm Res (2001) 18: 1528-1534 [PMID:11758759] |
Organic cation transporter 3/Solute carrier family 22 member 3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2073673] [GtoPdb: 1021] [UniProtKB: O75751] | ||||||||
ChEMBL | TP_TRANSPORTER: inhibition of MPP+ uptake in OCT3-expressing HRPE cells | F | 4.38 | pKi | 42000 | nM | Ki | Am J Physiol Renal Physiol (2000) 279: F449-F458 [PMID:10966924] |
sphingomyelin phosphodiesterase 1/Sphingomyelin phosphodiesterase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2760] [GtoPdb: 2514] [UniProtKB: P17405] | ||||||||
ChEMBL | Inhibition of mmLDL-stimulated acid sphingomyelinase in human PBMC lysates using 3H-sphingomyelin as substrate preincubated for 30 mins followed by mmLDL stimulation measured after 2 hrs by HPLC method | B | 5.3 | pIC50 | 5000 | nM | IC50 | Eur J Med Chem (2018) 153: 73-104 [PMID:29031494] |
Cav1.2/Voltage-gated L-type calcium channel alpha-1C subunit in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3762] [GtoPdb: 529] [UniProtKB: P22002] | ||||||||
ChEMBL | Inhibition of L-type calcium channel measured using whole-cell patch clamp in rat ventricular myocytes | F | 5.08 | pIC50 | 8300 | nM | IC50 | J Appl Toxicol (2012) 32: 858-866 [PMID:22761000] |
ChEMBL | Inhibition of L-type calcium channel measured using whole-cell patch clamp in rat ventricular myocytes | F | 5.39 | pIC50 | 4050 | nM | IC50 | J Appl Toxicol (2012) 32: 858-866 [PMID:22761000] |
M2 receptor in Human [GtoPdb: 14] [UniProtKB: P08172] | ||||||||
GtoPdb | - | - | 6.9 | pKi | - | - | - | J Pharmacol Exp Ther (1998) 284: 500-7 [PMID:9454790] |
Kir3.2 in Mouse [GtoPdb: 435] [UniProtKB: P48542] | ||||||||
GtoPdb | - | - | 4.3 | pIC50 | - | - | - | Neuropsychopharmacology (2004) 29: 1841-51 [PMID:15150531] |
Kir3.4 in Mouse [GtoPdb: 437] [UniProtKB: P48545] | ||||||||
GtoPdb | - | - | 4.5 | pEC50 | - | - | - | Neuropsychopharmacology (2004) 29: 1841-51 [PMID:15150531] |
Kv10.1 in Human [GtoPdb: 570] [UniProtKB: O95259] | ||||||||
GtoPdb | - | - | 5.7 | pIC50 | - | - | - | J Gen Physiol (2004) 124: 301-17 [PMID:15365094] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]