ChEMBL ligand: CHEMBL227934 (Strychnine)
glycine receptor α1 subunit/glycine receptor β subunit/glycine receptor α2 subunit/glycine receptor α3 subunit/Glycine receptor in Rat [ChEMBL: CHEMBL3392921] [GtoPdb: 423, 427, 424, 425] [UniProtKB: P07727, P20781, P22771, P24524] This target only has 1 pki data point 1 CHEMBL227934_lig_chart_1 Glycine receptor Rat There should be some charts here, you may need to enable JavaScript!
glycine receptor α1 subunit/glycine receptor β subunit/Glycine receptor (alpha-1/beta) in Human [ChEMBL: CHEMBL2363052] [GtoPdb: 423, 427] [UniProtKB: P23415, P48167] This target only has 0 pki data point 2 CHEMBL227934_lig_chart_2 Glycine receptor (alpha-1/beta) Human There should be some charts here, you may need to enable JavaScript!
glycine receptor α1 subunit/Glycine receptor subunit alpha-1 in Human [ChEMBL: CHEMBL5845] [GtoPdb: 423] [UniProtKB: P23415] glycine receptor α1 subunit/Glycine receptor subunit alpha-1 in Rat [ChEMBL: CHEMBL3246] [GtoPdb: 423] [UniProtKB: P07727] 3 CHEMBL227934_lig_chart_3 Glycine receptor subunit alpha-1 HumanRat There should be some charts here, you may need to enable JavaScript!
M1 receptor in Human [GtoPdb: 13] [UniProtKB: P11229] This target only has 0 pki data point 4 CHEMBL227934_lig_chart_4 M1 receptor Human There should be some charts here, you may need to enable JavaScript!
M2 receptor in Human [GtoPdb: 14] [UniProtKB: P08172] This target only has 0 pki data point 5 CHEMBL227934_lig_chart_5 M2 receptor Human There should be some charts here, you may need to enable JavaScript!
M3 receptor in Human [GtoPdb: 15] [UniProtKB: P20309] This target only has 0 pki data point 6 CHEMBL227934_lig_chart_6 M3 receptor Human There should be some charts here, you may need to enable JavaScript!
M4 receptor in Human [GtoPdb: 16] [UniProtKB: P08173] This target only has 0 pki data point 7 CHEMBL227934_lig_chart_7 M4 receptor Human There should be some charts here, you may need to enable JavaScript!
M5 receptor in Human [GtoPdb: 17] [UniProtKB: P08912] This target only has 0 pki data point 8 CHEMBL227934_lig_chart_8 M5 receptor Human There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
glycine receptor α1 subunit/glycine receptor β subunit/glycine receptor α2 subunit/glycine receptor α3 subunit/Glycine receptor in Rat (target type: PROTEIN COMPLEX GROUP) [ChEMBL: CHEMBL3392921] [GtoPdb: 423, 427, 424, 425] [UniProtKB: P07727, P20781, P22771, P24524]
ChEMBL	DRUGMATRIX: Glycine, Strychnine-Sensitive radioligand binding (ligand: [3H] Strychnine)	B	8.33	pKi	4.69	nM	Ki	DrugMatrix in vitro pharmacology data
ChEMBL	DRUGMATRIX: Glycine, Strychnine-Sensitive radioligand binding (ligand: [3H] Strychnine)	B	8.08	pIC50	8.29	nM	IC50	DrugMatrix in vitro pharmacology data
glycine receptor α1 subunit/glycine receptor β subunit/Glycine receptor (alpha-1/beta) in Human (target type: PROTEIN COMPLEX) [ChEMBL: CHEMBL2363052] [GtoPdb: 423, 427] [UniProtKB: P23415, P48167]
ChEMBL	Antagonist activity at recombinant human glycine receptor alpha 1 beta expressed in human tsA201 cells assessed as inhibition of glycine-induced receptor activation after 30 mins by FLIPR membrane potential blue assay	B	6.74	pIC50	181.97	nM	IC50	J Nat Prod (2016) 79: 2997-3005 [PMID:27966945]
ChEMBL	Antagonist activity at recombinant human glycine receptor alpha 1 beta expressed in human tsA201 cells assessed as inhibition of glycine-induced receptor activation after 30 mins by FLIPR membrane potential blue assay	B	6.74	pIC50	180	nM	IC50	J Nat Prod (2016) 79: 2997-3005 [PMID:27966945]
ChEMBL	Antagonist activity at recombinant human glycine receptor alpha 1 beta expressed in HEK293 cells assessed as inhibition of glycine-induced current at -50mV holding potential by whole cell patch-clamp method	B	7.24	pIC50	58	nM	IC50	J Nat Prod (2016) 79: 2997-3005 [PMID:27966945]
glycine receptor α1 subunit/Glycine receptor subunit alpha-1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5845] [GtoPdb: 423] [UniProtKB: P23415]
ChEMBL	Displacement of [3H]strychnine from recombinant human glycine receptor alpha 1 expressed in HEK293 cell membranes after 30 mins by liquid scintillation counting method	B	7.64	pKi	23	nM	Ki	J Nat Prod (2016) 79: 2997-3005 [PMID:27966945]
ChEMBL	Antagonist activity at recombinant human glycine receptor alpha 1 expressed in human tsA201 cells assessed as inhibition of glycine-induced receptor activation after 30 mins by FLIPR membrane potential blue assay	B	7.03	pIC50	93.33	nM	IC50	J Nat Prod (2016) 79: 2997-3005 [PMID:27966945]
ChEMBL	Antagonist activity at recombinant human glycine receptor alpha 1 expressed in human tsA201 cells assessed as inhibition of glycine-induced receptor activation after 30 mins by FLIPR membrane potential blue assay	B	7.03	pIC50	93	nM	IC50	J Nat Prod (2016) 79: 2997-3005 [PMID:27966945]
ChEMBL	Antagonist activity at recombinant human glycine receptor alpha 1 expressed in HEK293 cells assessed as inhibition of glycine-induced current at -50 mV holding potential by whole cell patch-clamp method	B	7.29	pIC50	51	nM	IC50	J Nat Prod (2016) 79: 2997-3005 [PMID:27966945]
glycine receptor α1 subunit/Glycine receptor subunit alpha-1 in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3246] [GtoPdb: 423] [UniProtKB: P07727]
ChEMBL	Displacement of [3H]strychnine from glycine receptor alpha 1 in rat brain synaptic membranes	B	7.92	pKi	12	nM	Ki	J Nat Prod (2016) 79: 2997-3005 [PMID:27966945]
M1 receptor in Human [GtoPdb: 13] [UniProtKB: P11229]
GtoPdb	-	-	4.9	pKd	-	-	-	Mol. Pharmacol. (1995) 48: 362-78 [PMID:7651370]
GtoPdb	-	-	5	pKd	-	-	-	Mol. Pharmacol. (1995) 48: 362-78 [PMID:7651370]; Mol. Pharmacol. (1997) 52: 172-9 [PMID:9224827]
M2 receptor in Human [GtoPdb: 14] [UniProtKB: P08172]
GtoPdb	-	-	5	pKd	-	-	-	Mol. Pharmacol. (1995) 48: 362-78 [PMID:7651370]; Mol. Pharmacol. (1997) 52: 172-9 [PMID:9224827]; Mol. Pharmacol. (2003) 64: 180-90 [PMID:12815174]
M3 receptor in Human [GtoPdb: 15] [UniProtKB: P20309]
GtoPdb	-	-	5.7	pKd	-	-	-	Mol. Pharmacol. (1995) 48: 362-78 [PMID:7651370]; Mol. Pharmacol. (1997) 52: 172-9 [PMID:9224827]
M4 receptor in Human [GtoPdb: 16] [UniProtKB: P08173]
GtoPdb	-	-	5	pKd	-	-	-	Mol. Pharmacol. (1995) 48: 362-78 [PMID:7651370]; Mol. Pharmacol. (1997) 52: 172-9 [PMID:9224827]
M5 receptor in Human [GtoPdb: 17] [UniProtKB: P08912]
GtoPdb	-	-	3.6	pKd	-	-	-	Mol. Pharmacol. (1995) 48: 362-78 [PMID:7651370]

ChEMBL data shown on this page come from version 27:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, Cibrián-Uhalte E, Davies M, Dedman N, Karlsson A, Magariños MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]