CP105696 [Ligand Id: 3368] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL51770 (CP-105696) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| BLT1 receptor/Leukotriene B4 receptor 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3911] [GtoPdb: 267] [UniProtKB: Q15722] | ||||||||
| ChEMBL | Tested for antagonistic activity against LTB4 receptor in guinea pig spleen membrane | F | 8.01 | pIC50 | 9.7 | nM | IC50 | J Med Chem (1994) 37: 3197-3199 [PMID:7932545] |
| ChEMBL | Compound was tested for inhibitory activity against Leukotriene B4 receptor binding | B | 8.08 | pIC50 | 8.4 | nM | IC50 | J Med Chem (1996) 39: 2629-2654 [PMID:8709092] |
| GtoPdb | - | - | 8.1 | pIC50 | 8.42 | nM | IC50 | J Pharmacol Exp Ther (1995) 273: 176-84 [PMID:7714764] |
| ChEMBL | Tested for binding activity against [3H]LTB4 to whole human neutrophil with halh maximal inhibition | B | 8.25 | pIC50 | 5.6 | nM | IC50 | J Med Chem (1994) 37: 3197-3199 [PMID:7932545] |
| BLT1 receptor/Leukotriene B4 receptor 1 in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2657] [GtoPdb: 267] [UniProtKB: O88855] | ||||||||
| ChEMBL | Tested for antagonistic activity in mouse spleen membrane against LTB4 receptor | F | 7.52 | pIC50 | 30.3 | nM | IC50 | J Med Chem (1994) 37: 3197-3199 [PMID:7932545] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
