LTD4 [Ligand Id: 3353] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL1521056
  • GPR17 in Human [GtoPdb: 88] [UniProtKB: Q13304]
  • GPR17 in Mouse [GtoPdb: 88] [UniProtKB: Q6NS65]
Created with Highcharts 10.3.3ValuesChart context menuGPR17pKd HumanpKi HumanpIC50 HumanpEC50 HumanpKd MousepKi MousepIC50 MousepEC50 Mouse0246810Highcharts.com
  • CysLT1 receptor in Human [GtoPdb: 269] [UniProtKB: Q9Y271]
Created with Highcharts 10.3.3ValuesChart context menuCysLT1 receptorpKd HumanpKi HumanpIC50 HumanpEC50 Human0246810Highcharts.com
  • CysLT2 receptor in Human [GtoPdb: 270] [UniProtKB: Q9NS75]
Created with Highcharts 10.3.3ValuesChart context menuCysLT2 receptorpKd HumanpKi HumanpIC50 HumanpEC50 Human0246810Highcharts.com
DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
GPR17 in Human [GtoPdb: 88] [UniProtKB: Q13304]
GtoPdb [35S]GTPÎłS binding to COS-7 cell membranes expressing hGPR17. - 8.36 pEC50 4.4 nM EC50 EMBO J (2006) 25: 4615-27 [PMID:16990797]
GPR17 in Mouse [GtoPdb: 88] [UniProtKB: Q6NS65]
GtoPdb - - 9.2 pEC50 0.63 nM EC50 PLoS ONE (2008) 3: e3579 [PMID:18974869]
CysLT1 receptor in Human [GtoPdb: 269] [UniProtKB: Q9Y271]
GtoPdb - - 8.05 pIC50 9 nM IC50 Mol Pharmacol (1999) 56: 657-63 [PMID:10462554]
GtoPdb - - 8.47 pEC50 3.4 nM EC50 Prostaglandins Other Lipid Mediat (2003) 71: 235-51 [PMID:14518564]
GtoPdb - - 8.52 pEC50 3 nM EC50 Nature (1999) 399: 789-93 [PMID:10391245]
GtoPdb - - 9.22 pEC50 0.6 nM EC50 Nature (1999) 399: 789-93 [PMID:10391245];
Mol Pharmacol (1999) 56: 657-63 [PMID:10462554];
Biochem Biophys Res Commun (2000) 274: 316-22 [PMID:10913337];
Mol Pharmacol (2000) 58: 1601-8 [PMID:11093801];
FASEB J (2011) 25: 3519-28 [PMID:21753081];
Pharmacogenet Genomics (2007) 17: 539-49 [PMID:17558309]
GtoPdb - - 9.4 pEC50 0.4 nM EC50 Nature (1999) 399: 789-93 [PMID:10391245]
CysLT2 receptor in Human [GtoPdb: 270] [UniProtKB: Q9NS75]
GtoPdb - - 8.1 pKi - - - Mol Pharmacol (1998) 53: 750-8 [PMID:9547367]
GtoPdb - - 7.23 pIC50 59 nM IC50 Biochem Biophys Res Commun (2000) 274: 316-22 [PMID:10913337]
GtoPdb - - 8.15 pIC50 7 nM IC50 Mol Pharmacol (2000) 58: 1601-8 [PMID:11093801]
GtoPdb - - 6.98 pEC50 104 nM EC50 J Biol Chem (2000) 275: 30531-6 [PMID:10851239];
Mol Pharmacol (2011) 79: 270-8 [PMID:21078884]
GtoPdb - - 7.44 pEC50 36 nM EC50 FASEB J (2011) 25: 3519-28 [PMID:21753081]
GtoPdb - - 7.46 pEC50 35 nM EC50 Mol Pharmacol (2011) 79: 270-8 [PMID:21078884]
GtoPdb - - 8.6 pEC50 2.5 nM EC50 Biochem Biophys Res Commun (2000) 274: 316-22 [PMID:10913337];
Mol Pharmacol (2000) 58: 1601-8 [PMID:11093801];
FASEB J (2011) 25: 3519-28 [PMID:21753081]

ChEMBL data shown on this page come from version 35:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]