hexahydrosiladifenidol [Ligand Id: 310] activity data from GtoPdb

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  • M1 receptor in Human [GtoPdb: 13] [UniProtKB: P11229]
  • M1 receptor in Rat [GtoPdb: 13] [UniProtKB: P08482]
Created with Highcharts 10.3.3ValuesChart context menuM1 receptorpKd HumanpKi HumanpIC50 HumanpEC50 HumanpKd RatpKi RatpIC50 RatpEC50 Rat0246810Highcharts.com
  • M2 receptor in Human [GtoPdb: 14] [UniProtKB: P08172]
  • M2 receptor in Rat [GtoPdb: 14] [UniProtKB: P10980]
Created with Highcharts 10.3.3ValuesChart context menuM2 receptorpKd HumanpKi HumanpIC50 HumanpEC50 HumanpKd RatpKi RatpIC50 RatpEC50 Rat02468Highcharts.com
  • M3 receptor in Human [GtoPdb: 15] [UniProtKB: P20309]
Created with Highcharts 10.3.3ValuesChart context menuM3 receptorpKd HumanpKi HumanpIC50 HumanpEC50 Human0246810Highcharts.com
  • M4 receptor in Human [GtoPdb: 16] [UniProtKB: P08173]
  • M4 receptor in Rat [GtoPdb: 16] [UniProtKB: P08485]
Created with Highcharts 10.3.3ValuesChart context menuM4 receptorpKd HumanpKi HumanpIC50 HumanpEC50 HumanpKd RatpKi RatpIC50 RatpEC50 Rat0246810Highcharts.com
  • M5 receptor in Human [GtoPdb: 17] [UniProtKB: P08912]
  • M5 receptor in Rat [GtoPdb: 17] [UniProtKB: P08911]
Created with Highcharts 10.3.3ValuesChart context menuM5 receptorpKd HumanpKi HumanpIC50 HumanpEC50 HumanpKd RatpKi RatpIC50 RatpEC50 Rat02468Highcharts.com
DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
M1 receptor in Human [GtoPdb: 13] [UniProtKB: P11229]
GtoPdb - - 7.7 pKi - - - Biochem Pharmacol (1996) 52: 643-58 [PMID:8759038]
M1 receptor in Rat [GtoPdb: 13] [UniProtKB: P08482]
GtoPdb - - 7.9 pKi - - - Life Sci (1992) 51: 955-71 [PMID:1325587];
Mol Pharmacol (1989) 35: 469-76 [PMID:2704370]
M2 receptor in Human [GtoPdb: 14] [UniProtKB: P08172]
GtoPdb - - 6.8 pKi - - - Biochem Pharmacol (1996) 52: 643-58 [PMID:8759038];
Mol Pharmacol (1989) 35: 469-76 [PMID:2704370];
J Pharmacol Exp Ther (1998) 284: 500-7 [PMID:9454790]
M2 receptor in Rat [GtoPdb: 14] [UniProtKB: P10980]
GtoPdb - - 6.8 pKi - - - Life Sci (1992) 51: 955-71 [PMID:1325587];
J Pharmacol Exp Ther (1998) 284: 500-7 [PMID:9454790]
M3 receptor in Human [GtoPdb: 15] [UniProtKB: P20309]
GtoPdb - - 8 pKi - - - Biochem Pharmacol (1996) 52: 643-58 [PMID:8759038];
Mol Pharmacol (1989) 35: 469-76 [PMID:2704370]
M4 receptor in Human [GtoPdb: 16] [UniProtKB: P08173]
GtoPdb - - 7.7 pKi - - - Biochem Pharmacol (1996) 52: 643-58 [PMID:8759038];
Mol Pharmacol (1989) 35: 469-76 [PMID:2704370]
M4 receptor in Rat [GtoPdb: 16] [UniProtKB: P08485]
GtoPdb - - 7.7 pKi - - - Life Sci (1992) 51: 955-71 [PMID:1325587]
M5 receptor in Human [GtoPdb: 17] [UniProtKB: P08912]
GtoPdb - - 7.2 pKi - - - Biochem Pharmacol (1996) 52: 643-58 [PMID:8759038];
Mol Pharmacol (1989) 35: 469-76 [PMID:2704370]
M5 receptor in Rat [GtoPdb: 17] [UniProtKB: P08911]
GtoPdb - - 7.4 pKi - - - Life Sci (1992) 51: 955-71 [PMID:1325587]

Our curators have not yet identified this ligand in ChEMBL, but you may find additional data by searching on the ChEMBL site using the ligand's name or structure.