pentylthio-TZTP [Ligand Id: 304] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL130715
  • M1 receptor in Human [GtoPdb: 13] [UniProtKB: P11229]
  • M1 receptor/Muscarinic acetylcholine receptor M1 in Rat [ChEMBL: CHEMBL276] [GtoPdb: 13] [UniProtKB: P08482]
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  • M2 receptor in Human [GtoPdb: 14] [UniProtKB: P08172]
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  • M3 receptor in Human [GtoPdb: 15] [UniProtKB: P20309]
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  • M4 receptor in Human [GtoPdb: 16] [UniProtKB: P08173]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
M1 receptor in Human [GtoPdb: 13] [UniProtKB: P11229]
GtoPdb - - 8.6 pKi - - - Mol Pharmacol (1997) 52: 172-9 [PMID:9224827]
M1 receptor/Muscarinic acetylcholine receptor M1 in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL276] [GtoPdb: 13] [UniProtKB: P08482]
ChEMBL Displacement of [3H]oxotremorine-M (Oxo-M) from rat hippocampus muscarinic acetylcholine receptor M1 B 8.32 pIC50 4.8 nM IC50 J. Med. Chem. (1992) 35: 4011-4019 [PMID:1433209]
ChEMBL Displacement of [3H]pirenzepine (Pz) from rat hippocampus muscarinic acetylcholine receptor M1 B 8.62 pIC50 2.4 nM IC50 J. Med. Chem. (1992) 35: 4011-4019 [PMID:1433209]
M2 receptor in Human [GtoPdb: 14] [UniProtKB: P08172]
GtoPdb - - 7.9 pKi - - - Mol Pharmacol (1997) 52: 172-9 [PMID:9224827]
M3 receptor in Human [GtoPdb: 15] [UniProtKB: P20309]
GtoPdb - - 8.1 pKi - - - Mol Pharmacol (1997) 52: 172-9 [PMID:9224827]
M4 receptor in Human [GtoPdb: 16] [UniProtKB: P08173]
GtoPdb - - 8.7 pKi - - - Mol Pharmacol (1997) 52: 172-9 [PMID:9224827]

ChEMBL data shown on this page come from version 31:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, Cibrián-Uhalte E, Davies M, Dedman N, Karlsson A, Magariños MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]