ChEMBL ligand: CHEMBL1144 (C10AA03, Pravachol, Pravastatin, Pravator)
hydroxymethylglutaryl-CoA reductase/HMG-CoA reductase in Human [ChEMBL: CHEMBL402] [GtoPdb: 639] [UniProtKB: P04035] hydroxymethylglutaryl-CoA reductase/HMG-CoA reductase in Rat [ChEMBL: CHEMBL3247] [GtoPdb: 639] [UniProtKB: P51639] There should be some charts here, you may need to enable JavaScript!
Organic anion transporter 1/Solute carrier family 22 member 6 in Rat [ChEMBL: CHEMBL1777665] [GtoPdb: 1025] [UniProtKB: O35956] There should be some charts here, you may need to enable JavaScript!
Organic anion transporter 3/Solute carrier family 22 member 8 in Human [ChEMBL: CHEMBL1641348] [GtoPdb: 1027] [UniProtKB: Q8TCC7] Organic anion transporter 3/Solute carrier family 22 member 8 in Rat [ChEMBL: CHEMBL2073666] [GtoPdb: 1027] [UniProtKB: Q9R1U7] There should be some charts here, you may need to enable JavaScript!
squalene monooxygenase/Squalene monooxygenase in Human [ChEMBL: CHEMBL3592] [GtoPdb: 2433] [UniProtKB: Q14534] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
hydroxymethylglutaryl-CoA reductase/HMG-CoA reductase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL402] [GtoPdb: 639] [UniProtKB: P04035]
GtoPdb	In vitro inhibition of HMG-CoA reductase	-	6.99	pKi	103	nM	Ki	Biochemistry (2005) 44: 11741-8 [PMID:16128575]
GtoPdb	In vitro inhibition of HMG-CoA reductase	-	5.86	pIC50	1370	nM	IC50	Bioorg Med Chem Lett (2001) 11: 1285-8 [PMID:11392538]
ChEMBL	Inhibition of human HMGR catalytic domain using 800 uM HMG-CoA as substrate measured every 20 secs for 10 mins	B	6.4	pIC50	400	nM	IC50	J Nat Prod (2016) 79: 1500-1507 [PMID:27228159]
GtoPdb	In vitro inhibition of HMG-CoA reductase	-	7.52	pIC50	30	nM	IC50	J Med Chem (1992) 35: 2095-103 [PMID:1597859]
ChEMBL	Tested in vitro for the inhibition of HMG-CoA reductase from partially purified microsomal preparations.	B	7.52	pIC50	30	nM	IC50	J Med Chem (1992) 35: 2095-2103 [PMID:1597859]
ChEMBL	DRUGMATRIX: HMG-CoA Reductase enzyme inhibition (substrate: [14C]HMG-CoA)	B	8.25	pIC50	5.59	nM	IC50	DrugMatrix in vitro pharmacology data
hydroxymethylglutaryl-CoA reductase/HMG-CoA reductase in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3247] [GtoPdb: 639] [UniProtKB: P51639]
ChEMBL	Inhibition of HMGR in rat hepatic microsomes assessed as conversion of [14C]HMG-CoA to [14C]mevalonic acid	B	7.5	pIC50	31.6	nM	IC50	J Med Chem (2008) 51: 2722-2733 [PMID:18412317]
ChEMBL	Inhibition of HMG-CoA reductase in Sprague-Dawley rat liver microsomes	B	7.89	pIC50	13	nM	IC50	J Med Chem (2008) 51: 31-45 [PMID:18072721]
GtoPdb	In vitro inhibition of HMG-CoA reductase	-	7.89	pIC50	13	nM	IC50	J Med Chem (2008) 51: 31-45 [PMID:18072721]
GtoPdb	in vitro inhibition of cholesterol synthesis	-	8.16	pIC50	6.93	nM	IC50	Am J Cardiol (2001) 87: 28B-32B [PMID:11256847]
GtoPdb	In vitro inhibition of HMG-CoA reductase	-	8.3	pIC50	5	nM	IC50	J Med Chem (1993) 36: 3658-62 [PMID:8246234]
GtoPdb	In vitro inhibition of HMG-CoA reductase	-	8.38	pEC50	4.2	nM	IC50	Bioorg Med Chem Lett (2001) 11: 1285-8 [PMID:11392538]
Organic anion transporter 1/Solute carrier family 22 member 6 in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1777665] [GtoPdb: 1025] [UniProtKB: O35956]
ChEMBL	Inhibition of rat Oat1 expressed in pig LLC-PK11 cells	B	4.28	pKi	52000	nM	Ki	Bioorg Med Chem (2011) 19: 3320-3340 [PMID:21571536]
Organic anion transporter 3/Solute carrier family 22 member 8 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1641348] [GtoPdb: 1027] [UniProtKB: Q8TCC7]
ChEMBL	TP_TRANSPORTER: inhibition of ES uptake (ES: 50nM) in hOAT3-expressing S2 cells	F	4.86	pIC50	13700	nM	IC50	J Pharmacol Sci (2004) 94: 197-202 [PMID:14978359]
Organic anion transporter 3/Solute carrier family 22 member 8 in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2073666] [GtoPdb: 1027] [UniProtKB: Q9R1U7]
ChEMBL	TP_TRANSPORTER: inhibition of ES uptake (ES: 50nM) in rOAT3-expressing S2 cells	F	4.81	pIC50	15600	nM	IC50	J Pharmacol Sci (2004) 94: 197-202 [PMID:14978359]
squalene monooxygenase/Squalene monooxygenase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3592] [GtoPdb: 2433] [UniProtKB: Q14534]
ChEMBL	In vitro inhibitory activity against pig liver microsomal squalene epoxidase	F	5	pIC50	>10000	nM	IC50	J Med Chem (1995) 38: 3207-3216 [PMID:7650673]

ChEMBL data shown on this page come from version 33:

Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]