Gene and Protein Information
Species	TM	AA	Chromosomal Location	Gene Symbol	Gene Name	Reference
Human	-	574	8q24.13	SQLE	squalene epoxidase	3
Mouse	-	572	15 D1	Sqle	squalene epoxidase
Rat	-	573	7q33	Sqle	squalene epoxidase

Previous and Unofficial Names

SE | squalene epoxidase

Database Links
Alphafold	Q14534 (Hs), P52019 (Mm), P52020 (Rn)
BRENDA	1.14.13.132
CATH/Gene3D	3.50.50.60
ChEMBL Target	CHEMBL3592 (Hs), CHEMBL4241 (Rn)
DrugBank Target	Q14534 (Hs)
Ensembl Gene	ENSG00000104549 (Hs), ENSMUSG00000022351 (Mm), ENSRNOG00000009550 (Rn)
Entrez Gene	6713 (Hs), 20775 (Mm), 29230 (Rn)
Human Protein Atlas	ENSG00000104549 (Hs)
KEGG Enzyme	1.14.13.132
KEGG Gene	hsa:6713 (Hs), mmu:20775 (Mm), rno:29230 (Rn)
OMIM	602019 (Hs)
Pharos	Q14534 (Hs)
RefSeq Nucleotide	NM_003129 (Hs), NM_009270 (Mm), NM_017136 (Rn)
RefSeq Protein	NP_003120 (Hs), NP_033296 (Mm), NP_058832 (Rn)
UniProtKB	Q14534 (Hs), P52019 (Mm), P52020 (Rn)
Wikipedia	SQLE (Hs)

Enzyme Reaction
EC Number: 1.14.13.132 H+ + NADPH + O2 + squalene = H2O + NADP+ + (S)-2,3-epoxysqualene

Cofactors
Cofactor Species Comments Reference flavin adenine dinucleotide Human 2

Download all structure-activity data for this target as a CSV file

Inhibitors
Key to terms and symbols	View all chemical structures	Click column headers to sort
Ligand Sp. Action Value Parameter Reference compound 1b [PMID: 9871762] Hs Inhibition 7.2 pIC50 1 ⤷ pIC50 7.2 (IC50 6x10-8 M) [1]

Tissue Distribution
Liver Species:  Human Technique:  PCR References:  2