AFD(R) [Ligand Id: 2937] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL382739 |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| S1P1 receptor/Sphingosine 1-phosphate receptor Edg-1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4333] [GtoPdb: 275] [UniProtKB: P21453] | ||||||||
| ChEMBL | Agonist activity at human S1PR1 expressed in CHO cells coexpressing CRE-beta-lactamase reporter assessed as inhibition of forskolin-stimulated beta-lactamase expression | F | 8.4 | pEC50 | 3.98 | nM | EC50 | Eur J Med Chem (2023) 250: 115182-115182 [PMID:36758307] |
| GtoPdb | - | - | 8.8 | pEC50 | - | - | - | J Biol Chem (2002) 277: 21453-7 [PMID:11967257] |
| ChEMBL | Binding potency at human S1P1 receptor by [35S]GTP-gamma-S binding assay | F | 9.1 | pEC50 | 0.79 | nM | EC50 | Bioorg Med Chem Lett (2006) 16: 84-87 [PMID:16236505] |
| S1P3 receptor/Sphingosine 1-phosphate receptor Edg-3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3892] [GtoPdb: 277] [UniProtKB: Q99500] | ||||||||
| ChEMBL | Binding potency at human S1P3 receptor by [35S]GTP-gamma-S binding assay | F | 8.2 | pEC50 | 6.31 | nM | EC50 | Bioorg Med Chem Lett (2006) 16: 84-87 [PMID:16236505] |
| GtoPdb | - | - | 9.4 | pEC50 | - | - | - | J Biol Chem (2002) 277: 21453-7 [PMID:11967257] |
| S1P4 receptor/Sphingosine 1-phosphate receptor Edg-6 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3230] [GtoPdb: 278] [UniProtKB: O95977] | ||||||||
| GtoPdb | - | - | 8.4 | pEC50 | - | - | - |
J Biol Chem (2002) 277: 21453-7 [PMID:11967257]; J Biol Chem (2004) 279: 13839-48 [PMID:14732717] |
| ChEMBL | Binding potency at human S1P4 receptor by [35S]GTP-gamma-S binding assay | F | 8.9 | pEC50 | 1.26 | nM | EC50 | Bioorg Med Chem Lett (2006) 16: 84-87 [PMID:16236505] |
| S1P5 receptor/Sphingosine 1-phosphate receptor Edg-8 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2274] [GtoPdb: 279] [UniProtKB: Q9H228] | ||||||||
| ChEMBL | Binding potency at human S1P5 receptor by [35S]GTP-gamma-S binding assay | F | 8.7 | pEC50 | 2 | nM | EC50 | Bioorg Med Chem Lett (2006) 16: 84-87 [PMID:16236505] |
| GtoPdb | - | - | 9.7 | pEC50 | - | - | - |
J Biol Chem (2002) 277: 21453-7 [PMID:11967257]; J Biol Chem (2004) 279: 13839-48 [PMID:14732717] |
ChEMBL data shown on this page come from version 34:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
