AFD(R) [Ligand Id: 2937] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL382739
  • S1P1 receptor/Sphingosine 1-phosphate receptor Edg-1 in Human [ChEMBL: CHEMBL4333] [GtoPdb: 275] [UniProtKB: P21453]
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  • S1P3 receptor/Sphingosine 1-phosphate receptor Edg-3 in Human [ChEMBL: CHEMBL3892] [GtoPdb: 277] [UniProtKB: Q99500]
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  • S1P4 receptor/Sphingosine 1-phosphate receptor Edg-6 in Human [ChEMBL: CHEMBL3230] [GtoPdb: 278] [UniProtKB: O95977]
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  • S1P5 receptor/Sphingosine 1-phosphate receptor Edg-8 in Human [ChEMBL: CHEMBL2274] [GtoPdb: 279] [UniProtKB: Q9H228]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
S1P1 receptor/Sphingosine 1-phosphate receptor Edg-1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4333] [GtoPdb: 275] [UniProtKB: P21453]
GtoPdb - - 8.8 pEC50 - - - J Biol Chem (2002) 277: 21453-7 [PMID:11967257]
ChEMBL Binding potency at human S1P1 receptor by [35S]GTP-gamma-S binding assay F 9.1 pEC50 0.79 nM EC50 Bioorg Med Chem Lett (2006) 16: 84-87 [PMID:16236505]
S1P3 receptor/Sphingosine 1-phosphate receptor Edg-3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3892] [GtoPdb: 277] [UniProtKB: Q99500]
ChEMBL Binding potency at human S1P3 receptor by [35S]GTP-gamma-S binding assay F 8.2 pEC50 6.31 nM EC50 Bioorg Med Chem Lett (2006) 16: 84-87 [PMID:16236505]
GtoPdb - - 9.4 pEC50 - - - J Biol Chem (2002) 277: 21453-7 [PMID:11967257]
S1P4 receptor/Sphingosine 1-phosphate receptor Edg-6 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3230] [GtoPdb: 278] [UniProtKB: O95977]
GtoPdb - - 8.4 pEC50 - - - J Biol Chem (2002) 277: 21453-7 [PMID:11967257];
J Biol Chem (2004) 279: 13839-48 [PMID:14732717]
ChEMBL Binding potency at human S1P4 receptor by [35S]GTP-gamma-S binding assay F 8.9 pEC50 1.26 nM EC50 Bioorg Med Chem Lett (2006) 16: 84-87 [PMID:16236505]
S1P5 receptor/Sphingosine 1-phosphate receptor Edg-8 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2274] [GtoPdb: 279] [UniProtKB: Q9H228]
ChEMBL Binding potency at human S1P5 receptor by [35S]GTP-gamma-S binding assay F 8.7 pEC50 2 nM EC50 Bioorg Med Chem Lett (2006) 16: 84-87 [PMID:16236505]
GtoPdb - - 9.7 pEC50 - - - J Biol Chem (2002) 277: 21453-7 [PMID:11967257];
J Biol Chem (2004) 279: 13839-48 [PMID:14732717]

ChEMBL data shown on this page come from version 32:

Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]