ChEMBL ligand: CHEMBL99521
M1 receptor/Muscarinic acetylcholine receptor M1 in Human [ChEMBL: CHEMBL216] [GtoPdb: 13] [UniProtKB: P11229] There should be some charts here, you may need to enable JavaScript!
M2 receptor/Muscarinic acetylcholine receptor M2 in Human [ChEMBL: CHEMBL211] [GtoPdb: 14] [UniProtKB: P08172] There should be some charts here, you may need to enable JavaScript!
M3 receptor in Human [GtoPdb: 15] [UniProtKB: P20309] There should be some charts here, you may need to enable JavaScript!
M4 receptor in Human [GtoPdb: 16] [UniProtKB: P08173] There should be some charts here, you may need to enable JavaScript!
M5 receptor in Human [GtoPdb: 17] [UniProtKB: P08912] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
M1 receptor/Muscarinic acetylcholine receptor M1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL216] [GtoPdb: 13] [UniProtKB: P11229]
GtoPdb	-	-	7.4	pKi	-	-	-	J Pharmacol Exp Ther (2001) 298: 1260-8 [PMID:11504829]
ChEMBL	Stimulation of phosphoinositide hydrolysis in A9L cells expressing human m1 receptor	F	7.8	pEC50	15.7	nM	EC50	Bioorg Med Chem Lett (1998) 8: 2897-2902 [PMID:9873644]
M2 receptor/Muscarinic acetylcholine receptor M2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL211] [GtoPdb: 14] [UniProtKB: P08172]
GtoPdb	-	-	7.2	pKi	-	-	-	J Pharmacol Exp Ther (2001) 298: 1260-8 [PMID:11504829]
ChEMBL	Stimulation of cAMP in CHO cells expressing human m2 receptor	F	7.21	pEC50	62	nM	EC50	Bioorg Med Chem Lett (1998) 8: 2897-2902 [PMID:9873644]
M3 receptor in Human [GtoPdb: 15] [UniProtKB: P20309]
GtoPdb	-	-	7.7	pKi	-	-	-	J Pharmacol Exp Ther (2001) 298: 1260-8 [PMID:11504829]
M4 receptor in Human [GtoPdb: 16] [UniProtKB: P08173]
GtoPdb	-	-	7.3	pKi	-	-	-	J Pharmacol Exp Ther (2001) 298: 1260-8 [PMID:11504829]
M5 receptor in Human [GtoPdb: 17] [UniProtKB: P08912]
GtoPdb	-	-	7.8	pKi	-	-	-	J Pharmacol Exp Ther (2001) 298: 1260-8 [PMID:11504829]

ChEMBL data shown on this page come from version 33:

Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]