ibuprofen [Ligand Id: 2713] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL521 (Aches-n-pain, Advil, Advil liqui-gels, Advil migraine liqui-gels, Anadin joint pain, Anadin liquifast, Anadin period pain relief, Anadin ultra, Apsifen, Apsifen-f, Arthrofen 200, Arthrofen 400, Arthrofen 600, Brufen ret, Burana, Caldolor, Cap-profen, Children's advil, Children's advil-flavored, Children's elixsure, Children's ibuprofen, Children's motrin, Codafen continus, Co-op, Cuprofen for child, Cuprofen plus, Deep relief, Ebufac, Femafen, Fenbid, Fenbid fte, Fenpaed, Feverfen, Fleximex, IB-100, Ibucalm, Ibuderm, Ibufac, Ibugel, Ibugel fte, Ibular, Ibuleve, Ibumed, Ibumetin, Ibumousse, Ibuprin, Ibuprofen, Ibuprofenum, Ibuprohm, Ibu-slo, Ibuspray, Ibu-tab, Ibu-tab 200, Ibutime, Inabrin, Infant's advil, Inoven, IP-82, Isisfen, Junifen, Junior strength advil, Junior strength ibuprofen, Junior strength motrin, Lidifen, Lidifen-f, Lobufen, M01AE01, Mandafen, Manorfen, Maxa-gesic, Medipren, Midol, Midol liquid gels, Migrafen, Motrin, Motrin ib, Motrin migraine pain, Novaprin, NSC-256857, Nuprin, Nurofen 400, Nurofen back pain sr, Nurofen child, Nurofen for child, Nurofen plus, Nurofen recovery, Nurofen sinus, Nurofen solb, Orbifen, Pacifene, Paxofen, Pedea, Pediatric advil, Phensic, Phor pain, Phorpain, Phorpain max strgh, Profen, Proflex, Proflex sr, RD 13621, Relcofen, Rimafen, Rufen, Seclodin, Suspren, Tab-profen, U-18,573, U-18573)
  • AKR1C3/Aldo-keto-reductase family 1 member C3 in Human [ChEMBL: CHEMBL4681] [GtoPdb: 1382] [UniProtKB: P42330]
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  • 5-LOX/Arachidonate 5-lipoxygenase in Human [ChEMBL: CHEMBL215] [GtoPdb: 1385] [UniProtKB: P09917]
  • 5-LOX/Arachidonate 5-lipoxygenase in Rat [ChEMBL: CHEMBL312] [GtoPdb: 1385] [UniProtKB: P12527]
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  • Dehydrogenase/reductase SDR family member 9 in Rat [ChEMBL: CHEMBL1075220] [UniProtKB: Q8VD48]
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  • epidermal growth factor receptor/Epidermal growth factor receptor erbB1 in Human [ChEMBL: CHEMBL203] [GtoPdb: 1797] [UniProtKB: P00533]
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  • fatty acid binding protein 1/Fatty acid-binding protein, liver in Rat [ChEMBL: CHEMBL5738] [GtoPdb: 2531] [UniProtKB: P02692]
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  • L-PGDS/Prostaglandin-H2 D-isomerase in Mouse [ChEMBL: CHEMBL4334] [GtoPdb: 1380] [UniProtKB: O09114]
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  • OAT6/Solute carrier family 22 member 20 in Mouse [ChEMBL: CHEMBL5269] [GtoPdb: 1037] [UniProtKB: Q80UJ1]
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  • Organic anion transporter 1/Solute carrier family 22 member 6 in Human [ChEMBL: CHEMBL1641347] [GtoPdb: 1025] [UniProtKB: Q4U2R8]
  • Organic anion transporter 1/Solute carrier family 22 member 6 in Mouse [ChEMBL: CHEMBL5653] [GtoPdb: 1025] [UniProtKB: Q8VC69]
  • Organic anion transporter 1/Solute carrier family 22 member 6 in Rat [ChEMBL: CHEMBL1777665] [GtoPdb: 1025] [UniProtKB: O35956]
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  • ASIC1 in Human [GtoPdb: 684] [UniProtKB: P78348]
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  • SMCT1 in Human [GtoPdb: 922] [UniProtKB: Q8N695]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
AKR1C3/Aldo-keto-reductase family 1 member C3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4681] [GtoPdb: 1382] [UniProtKB: P42330]
ChEMBL Inhibition of recombinant human AKR1C3 B 4.48 pIC50 33000 nM IC50 Bioorg Med Chem Lett (2005) 15: 5170-5175 [PMID:16183274]
ChEMBL Inhibition of AKR1C3 (unknown origin) B 5 pIC50 10000 nM IC50 Medchemcomm (2018) 9: 969-981 [PMID:30108986]
5-LOX/Arachidonate 5-lipoxygenase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL215] [GtoPdb: 1385] [UniProtKB: P09917]
ChEMBL Inhibitory activity against 5-lipoxygenase in Human whole blood (HWBL) stimulated with calcium ionophore (A23187) and LTB4 measured by enzyme immunoassay F 4.77 pIC50 17000 nM IC50 J Med Chem (1997) 40: 819-824 [PMID:9057869]
5-LOX/Arachidonate 5-lipoxygenase in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL312] [GtoPdb: 1385] [UniProtKB: P12527]
ChEMBL Inhibition of 5-LOX in RBL1 cells assessed as reduction in LTB4 production using A23187-induced arachidonic acid as substrate preincubated for 2 hrs followed by A23187 addition measured after 15 mins by LC-MS/MS analysis B 4 pIC50 >100000 nM IC50 ACS Med Chem Lett (2017) 8: 864-868 [PMID:28835803]
ChEMBL Inhibitory activity against 5-lipoxygenase catalysis (5-LO) in sonicated rat basophilic leukemia cell lysate F 4.85 pIC50 14000 nM IC50 J Med Chem (1997) 40: 819-824 [PMID:9057869]
COX-1 /Cyclooxygenase-1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL221] [GtoPdb: 1375] [UniProtKB: P23219]
ChEMBL Inhibition of human recombinant COX1 expressed in Sf9 cells using arachidonic acid and ADHP incubated for 3 mins by fluorimetry B 4.47 pIC50 34000 nM IC50 J Med Chem (2020) 63: 12614-12622 [PMID:32931274]
ChEMBL Inhibition of PGHS1 assessed as conversion of arachidonic acid to prostaglandin B 4.6 pIC50 25000 nM IC50 J Nat Prod (1999) 62: 294-296 [PMID:10075763]
ChEMBL Inhibition of COX1-catalyzed prostaglandin biosynthesis 10 mins of preincubation B 4.74 pIC50 18000 nM IC50 J Nat Prod (1998) 61: 1212-1215 [PMID:9784154]
ChEMBL Inhibition activity against recombinant human Prostaglandin G/H synthase 1 B 4.95 pIC50 11100 nM IC50 J Med Chem (1997) 40: 819-824 [PMID:9057869]
ChEMBL Inhibition of COX1 in human whole blood after 15 mins B 5.16 pIC50 6900 nM IC50 Bioorg Med Chem (2007) 15: 4876-4890 [PMID:17517512]
ChEMBL Compound was evaluated for inhibition of Prostaglandin G/H synthase 1 B 5.2 pIC50 6300 nM IC50 Bioorg Med Chem Lett (1996) 6: 707-712
GtoPdb - - 5.52 pIC50 3000 nM IC50 J Med Chem (1998) 41: 1124-37 [PMID:9544212]
ChEMBL Inhibition of Prostaglandin G/H synthase 1 (COX-1). B 5.52 pIC50 3000 nM IC50 J Med Chem (1998) 41: 1124-1137 [PMID:9544212]
ChEMBL Concentration (in uM) to inhibit 50% of Prostaglandin G/H synthase 1 (COX-1) and is expressed in IC50. B 5.52 pIC50 3000 nM IC50 J Med Chem (1998) 41: 1112-1123 [PMID:9544211]
ChEMBL Inhibitory activity against prostaglandin G/H synthase 1 (COX-1) B 5.52 pIC50 3000 nM IC50 J Med Chem (1998) 41: 3515-3529 [PMID:9719605]
ChEMBL Inhibition of COX-1 (unknown origin) using arachidonic acid as substrate measured after 10 mins by fluorometric based multimode microplate reader B 5.57 pIC50 2704 nM IC50 Eur J Med Chem (2021) 209: 112918-112918 [PMID:33071054]
ChEMBL Inhibition of COX-1 in human washed platelet assessed as inhibition of 10 uM arachidonic acid-induced TXB2 formation incubated for 25 mins prior to arachidonic acid challenge measured after 30 mins by radioimmunoassay B 5.73 pIC50 1860 nM IC50 J Med Chem (2013) 56: 4277-4299 [PMID:23651359]
ChEMBL Inhibition of COX-1 in human washed platelet assessed as inhibition of 0.5 uM arachidonic acid-induced TXB2 formation incubated for 25 mins prior to arachidonic acid challenge measured after 30 mins by radioimmunoassay B 6.54 pIC50 290 nM IC50 J Med Chem (2013) 56: 4277-4299 [PMID:23651359]
ChEMBL DRUGMATRIX: Cyclooxygenase COX-1 enzyme inhibition (substrate: Arachidonic acid) B 6.67 pIC50 212 nM IC50 DrugMatrix in vitro pharmacology data
Cyclooxygenase-1 in Bovine (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2860] [UniProtKB: O62664]
ChEMBL Inhibition of bovine seminal microsomal COX1 assessed as PGE2 production preincubated for 10 mins B 4.74 pIC50 18000 nM IC50 J Nat Prod (1998) 61: 2-7 [PMID:9461646]
ChEMBL Inhibition of bovine seminal microsomal COX1 assessed as PGE2 production B 4.89 pIC50 13000 nM IC50 J Nat Prod (1998) 61: 2-7 [PMID:9461646]
ChEMBL Inhibition of bovine COX1 by enzyme immunoassay B 5.54 pIC50 2900 nM IC50 J Med Chem (2009) 52: 1525-1529 [PMID:19296694]
ChEMBL Inhibition of bovine COX-1 by enzyme immuno assay B 5.54 pIC50 2900 nM IC50 Bioorg Med Chem Lett (2009) 19: 6855-6861 [PMID:19884005]
Cyclooxygenase-1 in Sheep (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2949] [UniProtKB: P05979]
ChEMBL Inhibition of sheep placental cotyledons COX1 B 5.05 pKi 9000 nM Ki J Med Chem (2011) 54: 8555-8562 [PMID:22091869]
ChEMBL Inhibition of ovine COX1 using arachidonic acid as substrate pretreated for 3 mins followed by substrate addition measured immediately B 4.14 pIC50 72800 nM IC50 J Nat Prod (2017) 80: 2472-2477 [PMID:28885836]
ChEMBL Competitive inhibition of ovine COX-1 assessed as reduction in PGE2 production using 6250 nM arachidonic acid as substrate preincubated with enzyme for 5 mins followed by substrate addition and measured after 20 mins by ELISA B 4.15 pIC50 70100 nM IC50 ACS Med Chem Lett (2021) 12: 610-616 [PMID:33854702]
ChEMBL Inhibition of ovine COX-1 assessed as decrease in PGH2 production using arachidonic acid as substrate treated with enzyme for 10 mins prior to substrate challenge for 2 mins by enzyme immunoassay B 4.59 pIC50 26000 nM IC50 Bioorg Med Chem Lett (2014) 24: 1958-1962 [PMID:24656662]
ChEMBL Inhibitory concentration against Prostaglandin G/H synthase 1 of ram seminal vesicles at 100 uM B 4.84 pIC50 14400 nM IC50 Bioorg Med Chem Lett (2005) 15: 1793-1797 [PMID:15780608]
ChEMBL Inhibition of ovine COX-1 assessed as residual activity by measuring formation of 12-HHT from arachidonic acid by HPLC analysis B 4.92 pIC50 12000 nM IC50 Bioorg Med Chem (2011) 19: 5372-5382 [PMID:21873070]
ChEMBL Inhibition of ovine COX1 after 5 mins B 4.92 pIC50 12000 nM IC50 J Med Chem (2010) 53: 4691-4700 [PMID:20503989]
ChEMBL Inhibition of purified ovine COX1 pre-treated for 1 hr before 10-acetyl-3,7-dihydroxyphenoxazin substrate addition in absence of porcine liver esterase by fluorescence assay B 5 pIC50 10100 nM IC50 ACS Med Chem Lett (2014) 5: 983-988 [PMID:25221653]
ChEMBL Inhibition of Ovine COX-1 preincubated for 15 mins by fluorescence analysis B 5 pIC50 >10000 nM IC50 ACS Med Chem Lett (2015) 6: 1086-1090 [PMID:26487917]
ChEMBL Tested for inhibitory activity against Prostaglandin G/H synthase 1 from ovine B 5.05 pIC50 9000 nM IC50 J Med Chem (1995) 38: 3895-3901 [PMID:7562922]
ChEMBL Inhibition of ram seminal vesicle COX1 assessed as reduction in PGE2 formation pre-incubated for 5 mins before arachidonic acid addition and measured after 20 mins by ELISA B 5.2 pIC50 6300 nM IC50 J Nat Prod (2017) 80: 999-1006 [PMID:28322565]
ChEMBL Inhibition of ovine COX1 pre-incubated for 10 mins before arachidonic acid substrate addition by enzyme immunoassay B 5.3 pIC50 5000 nM IC50 J Med Chem (2012) 55: 8807-8826 [PMID:23043222]
ChEMBL Inhibition of ovine COX1 using arachidonic acid as substrate pretreated for 5 mins followed by substrate addition and measured after 2 mins by fluorescence based enzyme immunoassay B 5.39 pIC50 4120 nM IC50 Eur J Med Chem (2019) 180: 86-98 [PMID:31301566]
ChEMBL Inhibition of ovine COX-1 B 5.4 pIC50 4000 nM IC50 J Med Chem (2011) 54: 1356-1364 [PMID:21280601]
ChEMBL Competitive inhibition of ovine COX-1 assessed as reduction in PGE2 production using 250 nM arachidonic acid as substrate preincubated with enzyme for 5 mins followed by substrate addition and measured after 20 mins by ELISA B 5.4 pIC50 4000 nM IC50 ACS Med Chem Lett (2021) 12: 610-616 [PMID:33854702]
ChEMBL Inhibition of ovine COX1 by enzyme immuno assay B 5.54 pIC50 2900 nM IC50 Bioorg Med Chem Lett (2011) 21: 6074-6080 [PMID:21890358]
ChEMBL Inhibition of ovine COX1 B 5.54 pIC50 2900 nM IC50 J Med Chem (2012) 55: 688-696 [PMID:22148253]
ChEMBL Inhibition of ovine COX1 B 5.54 pIC50 2900 nM IC50 Bioorg Med Chem Lett (2013) 23: 163-168 [PMID:23200247]
ChEMBL Inhibition of ovine COX1 by enzyme immuno assay B 5.54 pIC50 2900 nM IC50 Bioorg Med Chem (2007) 15: 4767-4774 [PMID:17509888]
ChEMBL Inhibition of ovine COX1 by enzyme immuno assay B 5.54 pIC50 2900 nM IC50 Bioorg Med Chem Lett (2016) 26: 406-412 [PMID:26691756]
ChEMBL In vitro inhibitory concentration against COX-1 enzyme B 5.54 pIC50 2900 nM IC50 J Med Chem (2005) 48: 4061-4067 [PMID:15943479]
ChEMBL Inhibition of ovine COX1 by enzyme immuno assay B 5.54 pIC50 2900 nM IC50 Bioorg Med Chem (2008) 16: 9694-9698 [PMID:18930406]
ChEMBL Inhibition of ovine COX1 by enzyme immunoassay B 5.54 pIC50 2900 nM IC50 Bioorg Med Chem Lett (2009) 19: 3014-3018 [PMID:19419861]
ChEMBL Inhibition of ovine COX1 by enzyme immunoassay B 5.54 pIC50 2900 nM IC50 Bioorg Med Chem (2009) 17: 5182-5188 [PMID:19500994]
ChEMBL Inhibition of ovine COX1 by enzyme immunoassay B 5.54 pIC50 2900 nM IC50 Bioorg Med Chem Lett (2010) 20: 1324-1329 [PMID:20097072]
ChEMBL Inhibition of ovine COX1 by enzyme immuno assay B 5.54 pIC50 2900 nM IC50 Bioorg Med Chem Lett (2010) 20: 896-902 [PMID:20045320]
ChEMBL Inhibition of ovine COX1 by enzyme immuno assay B 5.54 pIC50 2900 nM IC50 Bioorg Med Chem Lett (2010) 20: 2168-2173 [PMID:20202839]
ChEMBL Inhibition of sheep COX1 by enzyme immunoassay B 5.54 pIC50 2900 nM IC50 Bioorg Med Chem Lett (2010) 20: 4544-4549 [PMID:20576432]
ChEMBL Inhibition of ovine COX1 by enzyme immuno assay B 5.54 pIC50 2900 nM IC50 Bioorg Med Chem Lett (2011) 21: 3951-3956 [PMID:21641217]
ChEMBL Inhibition of ovine COX1 by enzyme immuno assay B 5.54 pIC50 2900 nM IC50 Bioorg Med Chem Lett (2009) 19: 584-588 [PMID:19136259]
ChEMBL Inhibition of ovine COX-1 assessed as reduction in PGE2 production using 10 uM arachidonic acid as substrate preincubated with enzyme for 5 mins followed by substrate addition and measured after 20 mins by ELISA B 5.66 pIC50 2190 nM IC50 ACS Med Chem Lett (2021) 12: 610-616 [PMID:33854702]
ChEMBL Inhibition of ovine COX1 assessed as reduction in Prostaglandin production by enzyme immunoassay B 5.85 pIC50 1420 nM IC50 Bioorg Med Chem (2018) 26: 891-902 [PMID:29373271]
ChEMBL Reversible competitive inhibition of prostaglandin G/H synthase 1 B 5.97 pIC50 1060 nM IC50 Bioorg Med Chem Lett (2004) 14: 667-671 [PMID:14741265]
COX-2 /Cyclooxygenase-2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL230] [GtoPdb: 1376] [UniProtKB: P35354]
ChEMBL Inhibition of human recombinant COX-2 assessed as residual activity by measuring formation of 12-HHT from arachidonic acid by HPLC analysis B 4.1 pIC50 80000 nM IC50 Bioorg Med Chem (2011) 19: 5372-5382 [PMID:21873070]
ChEMBL Inhibition of human recombinant COX2 after 5 mins B 4.1 pIC50 80000 nM IC50 J Med Chem (2010) 53: 4691-4700 [PMID:20503989]
ChEMBL Inhibition of human COX2 pre-incubated for 10 mins before substrate addition by enzyme immunoassay B 4.44 pIC50 36000 nM IC50 J Med Chem (2012) 55: 8807-8826 [PMID:23043222]
ChEMBL Inhibitory activity against prostaglandin G/H synthase 2 (COX-2) B 4.52 pIC50 30000 nM IC50 J Med Chem (1998) 41: 3515-3529 [PMID:9719605]
ChEMBL Concentration (in uM) to inhibit 50% of Prostaglandin G/H synthase 2 (COX-2) and is expressed in IC50. B 4.52 pIC50 30000 nM IC50 J Med Chem (1998) 41: 1112-1123 [PMID:9544211]
ChEMBL Inhibition of Prostaglandin G/H synthase 2 (COX-2). B 4.52 pIC50 30000 nM IC50 J Med Chem (1998) 41: 1124-1137 [PMID:9544212]
ChEMBL Inhibition of human recombinant COX-2 assessed as decrease in PGH2 production using arachidonic acid as substrate treated with enzyme for 10 mins prior to substrate challenge for 2 mins by enzyme immunoassay B 4.52 pIC50 30000 nM IC50 Bioorg Med Chem Lett (2014) 24: 1958-1962 [PMID:24656662]
ChEMBL DRUGMATRIX: Cyclooxygenase COX-2 enzyme inhibition (substrate: Arachidonic acid) B 4.59 pIC50 25530 nM IC50 DrugMatrix in vitro pharmacology data
ChEMBL Inhibition of COX2 (unknown origin) B 4.84 pIC50 14500 nM IC50 Eur J Med Chem (2017) 138: 1002-1033 [PMID:28759875]
ChEMBL Inhibition of recombinant human COX2 using arachidonic acid as substrate pretreated for 5 mins followed by substrate addition and measured after 2 mins by fluorescence based enzyme immunoassay B 5.05 pIC50 8910 nM IC50 Eur J Med Chem (2019) 180: 86-98 [PMID:31301566]
ChEMBL Tested for inhibitory activity against Prostaglandin G/H synthase 2 from human B 5.1 pIC50 8000 nM IC50 J Med Chem (1995) 38: 3895-3901 [PMID:7562922]
ChEMBL Inhibition of COX2 in human whole blood after 15 mins B 5.21 pIC50 6200 nM IC50 Bioorg Med Chem (2007) 15: 4876-4890 [PMID:17517512]
ChEMBL Inhibition of COX-2 (unknown origin) using arachidonic acid as substrate incubated for 5 to 10 mins by fluorometric analysis B 5.27 pIC50 5330 nM IC50 RSC Med Chem (2022) 13: 471-496 [PMID:35685617]
ChEMBL Inhibition of COX-2 (unknown origin) using arachidonic acid as substrate measured after 10 mins by fluorometric based multimode microplate reader B 5.27 pIC50 5326 nM IC50 Eur J Med Chem (2021) 209: 112918-112918 [PMID:33071054]
ChEMBL Inhibition of human recombinant COX2 pre-treated for 1 hr before 10-acetyl-3,7-dihydroxyphenoxazin substrate addition in absence of porcine liver esterase by fluorescence assay B 5.37 pIC50 4300 nM IC50 ACS Med Chem Lett (2014) 5: 983-988 [PMID:25221653]
ChEMBL Inhibition of human recombinant COX2 assessed as reduction in PGE2 formation pre-incubated for 5 mins before arachidonic acid addition and measured after 20 mins by ELISA B 5.38 pIC50 4200 nM IC50 J Nat Prod (2017) 80: 999-1006 [PMID:28322565]
ChEMBL Inhibition of human recombinant COX2 expressed in Sf9 cells using arachidonic acid and ADHP incubated for 5 mins by fluorimetry B 5.48 pIC50 3300 nM IC50 J Med Chem (2020) 63: 12614-12622 [PMID:32931274]
ChEMBL Inhibition of human recombinant COX-2 assessed as reduction in PGE2 production using 10 uM arachidonic acid as substrate preincubated with enzyme for 5 mins followed by substrate addition and measured after 20 mins by ELISA B 5.48 pIC50 3300 nM IC50 ACS Med Chem Lett (2021) 12: 610-616 [PMID:33854702]
ChEMBL Inhibition of human recombinant COX2 assessed as reduction in PGE2 production using arachidonic acid substrate by ELISA B 5.7 pIC50 2000 nM IC50 J Nat Prod (2019) 82: 1839-1848 [PMID:31268709]
ChEMBL Inhibition of COX2 (unknown origin) assessed as reduction in PGF2alpha content using arachidonic acid as substrate preincubated for 10 mins followed by substrate addition and measured after 2 mins by enzyme immunoassay B 5.75 pIC50 1790 nM IC50 J Med Chem (2022) 65: 14916-14937 [PMID:36282007]
ChEMBL Inhibition of human recombinant COX-2 B 5.85 pIC50 1400 nM IC50 J Med Chem (2011) 54: 1356-1364 [PMID:21280601]
ChEMBL Inhibition of human COX2 expressed in baculovirus system B 5.87 pIC50 1350 nM IC50 J Med Chem (2011) 54: 8555-8562 [PMID:22091869]
GtoPdb - - 5.87 pIC50 1350 nM IC50 J Med Chem (2011) 54: 8555-62 [PMID:22091869]
ChEMBL Inhibition of human recombinant COX-2 by enzyme immuno assay B 5.96 pIC50 1100 nM IC50 Bioorg Med Chem Lett (2009) 19: 6855-6861 [PMID:19884005]
ChEMBL Inhibition of human recombinant COX2 by enzyme immuno assay B 5.96 pIC50 1100 nM IC50 Bioorg Med Chem Lett (2011) 21: 3951-3956 [PMID:21641217]
ChEMBL Inhibition of human COX2 by enzyme immunoassay B 5.96 pIC50 1100 nM IC50 Bioorg Med Chem Lett (2010) 20: 4544-4549 [PMID:20576432]
ChEMBL Inhibition of human recombinant COX2 B 5.96 pIC50 1100 nM IC50 J Med Chem (2012) 55: 688-696 [PMID:22148253]
ChEMBL Inhibition of human recombinant COX2 by enzyme immuno assay B 5.96 pIC50 1100 nM IC50 Bioorg Med Chem Lett (2010) 20: 2168-2173 [PMID:20202839]
ChEMBL Inhibition of human recombinant COX2 B 5.96 pIC50 1100 nM IC50 Bioorg Med Chem Lett (2013) 23: 163-168 [PMID:23200247]
ChEMBL Inhibition of human recombinant COX2 by enzyme immunoassay B 5.96 pIC50 1100 nM IC50 Bioorg Med Chem Lett (2010) 20: 1324-1329 [PMID:20097072]
ChEMBL Inhibition of recombinant human COX-2 preincubated for 15 mins by fluorescence analysis B 5.96 pIC50 1100 nM IC50 ACS Med Chem Lett (2015) 6: 1086-1090 [PMID:26487917]
ChEMBL Inhibition of human recombinant COX2 by enzyme immuno assay B 5.96 pIC50 1100 nM IC50 Bioorg Med Chem Lett (2016) 26: 406-412 [PMID:26691756]
ChEMBL Inhibition of human recombinant COX2 by enzyme immunoassay B 5.96 pIC50 1100 nM IC50 Bioorg Med Chem (2009) 17: 5182-5188 [PMID:19500994]
ChEMBL Inhibition of recombinant human N-terminal His-tagged COX2 expressed in baculovirus infected Sf21 cells assessed as reduction in prostaglandin production by enzyme immunoassay B 5.97 pIC50 1080 nM IC50 Bioorg Med Chem (2018) 26: 891-902 [PMID:29373271]
ChEMBL Inhibition activity against recombinant human Prostaglandin G/H synthase 2 B 7 pIC50 100 nM IC50 J Med Chem (1997) 40: 819-824 [PMID:9057869]
Cyclooxygenase-2 in Bovine (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3331] [UniProtKB: O62698]
ChEMBL Inhibition of bovine COX2 by enzyme immunoassay B 5.96 pIC50 1100 nM IC50 J Med Chem (2009) 52: 1525-1529 [PMID:19296694]
Cyclooxygenase-2 in Sheep (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4102] [UniProtKB: P79208]
ChEMBL Inhibition of sheep placental cotyledons COX2 B 5.05 pKi 9000 nM Ki J Med Chem (2011) 54: 8555-8562 [PMID:22091869]
ChEMBL Inhibition of ovine COX2 assessed as reduction in PGH2 production by enzyme immunoassay B 5.85 pIC50 1400 nM IC50 Bioorg Med Chem (2018) 26: 4113-4126 [PMID:29980364]
ChEMBL Inhibition of ovine COX2 by enzyme immuno assay B 5.96 pIC50 1100 nM IC50 Bioorg Med Chem (2007) 15: 4767-4774 [PMID:17509888]
ChEMBL Inhibition of ovine COX2 by enzyme immuno assay B 5.96 pIC50 1100 nM IC50 Bioorg Med Chem (2008) 16: 9694-9698 [PMID:18930406]
ChEMBL Inhibition of ovine COX2 by enzyme immuno assay B 5.96 pIC50 1100 nM IC50 Bioorg Med Chem Lett (2009) 19: 584-588 [PMID:19136259]
ChEMBL In vitro inhibitory concentration against COX-2 enzyme B 5.96 pIC50 1100 nM IC50 J Med Chem (2005) 48: 4061-4067 [PMID:15943479]
ChEMBL Inhibition of ovine COX2 by enzyme immuno assay B 5.96 pIC50 1100 nM IC50 Bioorg Med Chem Lett (2010) 20: 896-902 [PMID:20045320]
ChEMBL Inhibition of ovine COX2 by enzyme immuno assay B 5.96 pIC50 1100 nM IC50 Bioorg Med Chem Lett (2011) 21: 6074-6080 [PMID:21890358]
ChEMBL Inhibition of ovine COX2 by enzyme immunoassay B 5.96 pIC50 1100 nM IC50 Bioorg Med Chem Lett (2009) 19: 3014-3018 [PMID:19419861]
COX-2 /Cyclooxygenase-2 in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4321] [GtoPdb: 1376] [UniProtKB: Q05769]
ChEMBL Inhibition of COX-2 in mouse RAW264.7 cells assessed as decrease in LPS-induced PGE2 production treated prior to LPS challenge by enzyme immunoassay B 6.07 pIC50 860 nM IC50 Bioorg Med Chem Lett (2014) 24: 1958-1962 [PMID:24656662]
Dehydrogenase/reductase SDR family member 9 in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1075220] [UniProtKB: Q8VD48]
ChEMBL Inhibition of rat liver 3-alpha-HSD assessed as 5-beta-dihydrocortisone reduction B 4 pIC50 100000 nM IC50 Bioorg Med Chem (2007) 15: 4876-4890 [PMID:17517512]
epidermal growth factor receptor/Epidermal growth factor receptor erbB1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL203] [GtoPdb: 1797] [UniProtKB: P00533]
ChEMBL Inhibition of EGFR (unknown origin) using tyrosine 4 as substrate by fluorescence analysis B 5 pIC50 >10000 nM IC50 ACS Med Chem Lett (2015) 6: 1086-1090 [PMID:26487917]
fatty acid binding protein 1/Fatty acid-binding protein, liver in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5738] [GtoPdb: 2531] [UniProtKB: P02692]
ChEMBL Displacement of 1-anilinonaphthalene-8-sulphonic acid from rat recombinant L-FABP high binding affinity site expressed in Escherichia coli BL21 by competitive fluorescence displacement assay B 4.32 pKi 47600 nM Ki J Med Chem (2008) 51: 3755-3764 [PMID:18533710]
L-PGDS/Prostaglandin-H2 D-isomerase in Mouse (target type: SINGLE PROTEIN) [ChEMBL: