rottlerin [Ligand Id: 2611] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL34241 (Rottlerin)
  • chymotrypsinogen B1/Beta-chymotrypsin in Human [ChEMBL: CHEMBL4796] [GtoPdb: 3272] [UniProtKB: P17538]
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  • Beta-lactamase in Enterobacter cloacae [ChEMBL: CHEMBL2725] [UniProtKB: P05364]
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  • Beta-lactamase AmpC in Escherichia coli [ChEMBL: CHEMBL2026] [UniProtKB: P00811]
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  • Malate dehydrogenase in Thermus thermophilus [ChEMBL: CHEMBL4255] [UniProtKB: P10584]
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  • MAPK activated protein kinase 2/MAP kinase-activated protein kinase 2 in Human [ChEMBL: CHEMBL2208] [GtoPdb: 2094] [UniProtKB: P49137]
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  • MAPK activated protein kinase 5/MAP kinase-activated protein kinase 5 in Human [ChEMBL: CHEMBL3094] [GtoPdb: 2096] [UniProtKB: Q8IW41]
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  • protein kinase C delta/Protein kinase C delta in Human [ChEMBL: CHEMBL2996] [GtoPdb: 1485] [UniProtKB: Q05655]
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  • eukaryotic elongation factor 2 kinase/Serine/threonine-protein kinase EEF2K in Human [ChEMBL: CHEMBL5026] [GtoPdb: 2014] [UniProtKB: O00418]
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  • ubiquitin specific peptidase 1/Ubiquitin carboxyl-terminal hydrolase 1/WD repeat-containing protein 48 in Human [ChEMBL: CHEMBL3430885] [GtoPdb: 2428] [UniProtKB: O94782Q8TAF3]
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  • Kv11.1 in Human [GtoPdb: 572] [UniProtKB: Q12809]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
chymotrypsinogen B1/Beta-chymotrypsin in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4796] [GtoPdb: 3272] [UniProtKB: P17538]
ChEMBL Inhibitory activity against Chymotrypsinogen from Thermus flavus B 4.6 pIC50 25000 nM IC50 J Med Chem (2003) 46: 1478-1483 [PMID:12672248]
Beta-lactamase in Enterobacter cloacae (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2725] [UniProtKB: P05364]
ChEMBL Inhibition of Enterobacter cloacae beta-lactamase incubated for 10 mins followed by nitrocefin substrate challenge and measured for 5 mins by spectrophotometric analysis B 4.02 pIC50 96000 nM IC50 ACS Med Chem Lett (2019) 10: 923-928 [PMID:31223449]
Beta-lactamase AmpC in Escherichia coli (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2026] [UniProtKB: P00811]
ChEMBL Inhibition of 30 nM AmpC beta lactamase B 4.12 pIC50 76000 nM IC50 J Med Chem (2006) 49: 7274-7277 [PMID:17149857]
ChEMBL Inhibition of 10 nM AmpC beta lactamase B 4.68 pIC50 21000 nM IC50 J Med Chem (2006) 49: 7274-7277 [PMID:17149857]
ChEMBL Inhibition of 1 nM AmpC beta lactamase B 5.74 pIC50 1800 nM IC50 J Med Chem (2006) 49: 7274-7277 [PMID:17149857]
ChEMBL Inhibitory activity against Amp C beta-Lactamase B 5.92 pIC50 1200 nM IC50 J Med Chem (2003) 46: 4265-4272 [PMID:13678405]
Malate dehydrogenase in Thermus thermophilus (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4255] [UniProtKB: P10584]
ChEMBL Inhibitory activity against malate dehydrogenase (MDH) from Thermus flavus B 6.15 pIC50 700 nM IC50 J Med Chem (2003) 46: 1478-1483 [PMID:12672248]
MAPK activated protein kinase 2/MAP kinase-activated protein kinase 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2208] [GtoPdb: 2094] [UniProtKB: P49137]
ChEMBL Inhibition of His-tagged human MAPKAPK2 expressed in Escherichia coli at 10 uM B 5.27 pIC50 5400 nM IC50 Biochem J (2000) 351: 95-105 [PMID:10998351]
MAPK activated protein kinase 5/MAP kinase-activated protein kinase 5 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3094] [GtoPdb: 2096] [UniProtKB: Q8IW41]
ChEMBL Inhibition of p38-regulated activated kinase (PRAK) B 5.72 pIC50 1900 nM IC50 J Med Chem (2003) 46: 1478-1483 [PMID:12672248]
ChEMBL Inhibition of His-tagged human PRAK expressed in Sf9 cells B 5.72 pIC50 1900 nM IC50 Biochem J (2000) 351: 95-105 [PMID:10998351]
Plasmodium falciparum (target type: ORGANISM) [ChEMBL: CHEMBL364]
ChEMBL Antiplasmodial activity against Plasmodium falciparum Dd2 after 72 hrs by SYBR green assay F 5 pIC50 10000 nM IC50 Nat Chem Biol (2009) 5: 765-771 [PMID:19734910]
ChEMBL Antiplasmodial activity against Plasmodium falciparum D10 after 72 hrs by SYBR green assay F 5 pIC50 10000 nM IC50 Nat Chem Biol (2009) 5: 765-771 [PMID:19734910]
ChEMBL Antiplasmodial activity against Plasmodium falciparum HB3 after 72 hrs by SYBR green assay F 5.3 pIC50 5011.87 nM IC50 Nat Chem Biol (2009) 5: 765-771 [PMID:19734910]
ChEMBL Antiplasmodial activity against Plasmodium falciparum 3D7 after 72 hrs by SYBR green assay F 5.4 pIC50 3981.07 nM IC50 Nat Chem Biol (2009) 5: 765-771 [PMID:19734910]
ChEMBL Antiplasmodial activity against Plasmodium falciparum W2 after 72 hrs by SYBR green assay F 5.5 pIC50 3162.28 nM IC50 Nat Chem Biol (2009) 5: 765-771 [PMID:19734910]
ChEMBL Antiplasmodial activity against Plasmodium falciparum GB4 after 72 hrs by SYBR green assay F 5.5 pIC50 3162.28 nM IC50 Nat Chem Biol (2009) 5: 765-771 [PMID:19734910]
ChEMBL Antiplasmodial activity against Plasmodium falciparum 7G8 after 72 hrs by SYBR green assay F 5.5 pIC50 3162.28 nM IC50 Nat Chem Biol (2009) 5: 765-771 [PMID:19734910]
protein kinase C delta/Protein kinase C delta in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2996] [GtoPdb: 1485] [UniProtKB: Q05655]
GtoPdb - - 5.52 pIC50 3020 nM IC50 Biochem Biophys Res Commun (1994) 199: 93-8 [PMID:8123051]
ChEMBL Inhibition of Protein kinase C delta (PKCdelta) B 5.52 pIC50 3000 nM IC50 J Med Chem (2003) 46: 1478-1483 [PMID:12672248]
ChEMBL Inhibition of PKCdelta (unknown origin) by IMAP kinase assay B 5.52 pIC50 3000 nM IC50 J Med Chem (2022) 65: 3134-3150 [PMID:35167283]
RuvB-like 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3259467] [UniProtKB: Q9Y265]
ChEMBL Inhibition of RUVBL1 (unknown origin) B 5 pIC50 10000 nM IC50 Bioorg Med Chem (2022) 62: 116726-116726 [PMID:35364523]
eukaryotic elongation factor 2 kinase/Serine/threonine-protein kinase EEF2K in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5026] [GtoPdb: 2014] [UniProtKB: O00418]
ChEMBL Inhibition of eEF2K (unknown origin) B 5.28 pIC50 5300 nM IC50 Eur J Med Chem (2020) 204: 112505-112505 [PMID:32717479]
ubiquitin specific peptidase 1/Ubiquitin carboxyl-terminal hydrolase 1/WD repeat-containing protein 48 in Human (target type: PROTEIN COMPLEX) [ChEMBL: CHEMBL3430885] [GtoPdb: 2428] [UniProtKB: O94782Q8TAF3]
ChEMBL Inhibition of human USP1/UAF1 complex using Ub-Rho as substrate by qHTS assay B 5.1 pIC50 8000 nM IC50 J Med Chem (2016) 59: 9321-9336 [PMID:27362876]
Kv11.1 in Human [GtoPdb: 572] [UniProtKB: Q12809]
GtoPdb - - 6.5 pEC50 - - - J Pharmacol Exp Ther (2006) 319: 957-62 [PMID:16928897]

ChEMBL data shown on this page come from version 34:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]