5-(4-phenoxybutoxy)psoralen [Ligand Id: 2554] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL444449 (5-(4-Phenoxybutoxy)Psoralen) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| KCa1.1/Calcium-activated potassium channel subunit alpha-1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4304] [GtoPdb: 380] [UniProtKB: Q12791] | ||||||||
| ChEMBL | Inhibition of BK (unknown origin) | B | 5.82 | pEC50 | 1500 | nM | EC50 | US-20060079535-A1. 5-phenoxyalkoxypsoralens and methods for selective inhibition of the voltage gated kv1.3 potassium channel (2006) |
| Kv11.1/HERG in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL240] [GtoPdb: 572] [UniProtKB: Q12809] | ||||||||
| ChEMBL | Inhibition of human ERG | B | 5.3 | pEC50 | 5000 | nM | EC50 | US-20060079535-A1. 5-phenoxyalkoxypsoralens and methods for selective inhibition of the voltage gated kv1.3 potassium channel (2006) |
| KCa3.1/Intermediate conductance calcium-activated potassium channel protein 4 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4305] [GtoPdb: 384] [UniProtKB: O15554] | ||||||||
| ChEMBL | Inhibition of human cloned IK1 expressed in african green monkey COS7 cells by whole cell patch clamp assay | B | 5 | pIC50 | 10000 | nM | IC50 | Bioorg Med Chem Lett (2009) 19: 2299-2304 [PMID:19282171] |
| ChEMBL | Inhibition of IKCa1 (unknown origin) | B | 5 | pEC50 | 10000 | nM | EC50 | US-20060079535-A1. 5-phenoxyalkoxypsoralens and methods for selective inhibition of the voltage gated kv1.3 potassium channel (2006) |
| KCa2.1/Small conductance calcium-activated potassium channel protein 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2369] [GtoPdb: 381] [UniProtKB: Q92952] | ||||||||
| ChEMBL | Inhibition of SKCa1 (unknown origin) | B | 5.3 | pEC50 | 5000 | nM | EC50 | US-20060079535-A1. 5-phenoxyalkoxypsoralens and methods for selective inhibition of the voltage gated kv1.3 potassium channel (2006) |
| KCa2.2/Small conductance calcium-activated potassium channel protein 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4469] [GtoPdb: 382] [UniProtKB: Q9H2S1] | ||||||||
| ChEMBL | Inhibition of SKCa2 (unknown origin) | B | 5.3 | pEC50 | 5000 | nM | EC50 | US-20060079535-A1. 5-phenoxyalkoxypsoralens and methods for selective inhibition of the voltage gated kv1.3 potassium channel (2006) |
| Kv1.1/Voltage-gated potassium channel subunit Kv1.1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2309] [GtoPdb: 538] [UniProtKB: Q09470] | ||||||||
| ChEMBL | Inhibition of human Kv1.1 expressed in CHO cells at -80 mV holding potential by whole cell automated patch clamp method | B | 6.6 | pIC50 | 250 | nM | IC50 | Eur J Med Chem (2017) 139: 232-241 [PMID:28802123] |
| ChEMBL | Inhibition of Kv1.1 (unknown origin) | B | 7.19 | pEC50 | 65 | nM | EC50 | US-20060079535-A1. 5-phenoxyalkoxypsoralens and methods for selective inhibition of the voltage gated kv1.3 potassium channel (2006) |
| Kv1.2/Voltage-gated potassium channel subunit Kv1.2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2086] [GtoPdb: 539] [UniProtKB: P16389] | ||||||||
| ChEMBL | Inhibition of human Kv1.2 expressed in CHO cells at -80 mV holding potential by whole cell automated patch clamp method | B | 6.35 | pIC50 | 450 | nM | IC50 | Eur J Med Chem (2017) 139: 232-241 [PMID:28802123] |
| ChEMBL | Inhibition of Kv1.2 (unknown origin) | B | 6.6 | pEC50 | 250 | nM | EC50 | US-20060079535-A1. 5-phenoxyalkoxypsoralens and methods for selective inhibition of the voltage gated kv1.3 potassium channel (2006) |
| Kv1.3/Voltage-gated potassium channel subunit Kv1.3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4633] [GtoPdb: 540] [UniProtKB: P22001] | ||||||||
| ChEMBL | Inhibition of human Kv1.3 ion channel expressed in CGE22 cells | B | 6.13 | pIC50 | 740 | nM | IC50 | Bioorg Med Chem Lett (2010) 20: 6989-6992 [PMID:20974533] |
| ChEMBL | Inhibition of human Kv1.3 expressed in CHO cells at -80 mV holding potential by whole cell automated patch clamp method | B | 7.62 | pIC50 | 24 | nM | IC50 | Eur J Med Chem (2017) 139: 232-241 [PMID:28802123] |
| ChEMBL | Inhibition of cloned Kv1.3 channel expressed in mammalian cells by whole cell patch clamp assay | B | 8 | pIC50 | 10 | nM | IC50 | Bioorg Med Chem Lett (2009) 19: 2299-2304 [PMID:19282171] |
| ChEMBL | Inhibition of Kv1.3 potassium channel expressed in mouse L929 cells by whole cell patch clamp | B | 8.7 | pIC50 | 2 | nM | IC50 | Eur J Med Chem (2009) 44: 1838-1852 [PMID:19056148] |
| ChEMBL | Inhibition of Kv1.3 expressed in mouse L929 cells exposed to depolarizing step pulses from -80 mV to +40 mV by whole cell patch clamp method | B | 8.7 | pIC50 | 2 | nM | IC50 | Bioorg Med Chem Lett (2012) 22: 7106-7109 [PMID:23084278] |
| ChEMBL | Inhibition of Kv1.3 (unknown origin) | B | 8.7 | pEC50 | 2 | nM | EC50 | US-20060079535-A1. 5-phenoxyalkoxypsoralens and methods for selective inhibition of the voltage gated kv1.3 potassium channel (2006) |
| Kv1.3 in Mouse [GtoPdb: 540] [UniProtKB: P16390] | ||||||||
| GtoPdb | - | - | 8.7 | pEC50 | - | - | - | Mol Pharmacol (2005) 68: 1254-70 [PMID:16099841] |
| Kv1.4/Voltage-gated potassium channel subunit Kv1.4 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4205] [GtoPdb: 541] [UniProtKB: P22459] | ||||||||
| ChEMBL | Inhibition of human Kv1.4 expressed in CHO cells at -80 mV holding potential by whole cell automated patch clamp method | B | 6.77 | pIC50 | 170 | nM | IC50 | Eur J Med Chem (2017) 139: 232-241 [PMID:28802123] |
| ChEMBL | Inhibition of Kv1.4 (unknown origin) | B | 7.12 | pEC50 | 75 | nM | EC50 | US-20060079535-A1. 5-phenoxyalkoxypsoralens and methods for selective inhibition of the voltage gated kv1.3 potassium channel (2006) |
| Kv1.5/Voltage-gated potassium channel subunit Kv1.5 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4306] [GtoPdb: 542] [UniProtKB: P22460] | ||||||||
| ChEMBL | Inhibition of human Kv1.5 ion channel expressed in CHO K1 cells | B | 5.46 | pIC50 | 3450 | nM | IC50 | Bioorg Med Chem Lett (2010) 20: 6989-6992 [PMID:20974533] |
| ChEMBL | Inhibition of human Kv1.5 expressed in CHO cells at -80 mV holding potential by whole cell automated patch clamp method | B | 7.06 | pIC50 | 88 | nM | IC50 | Eur J Med Chem (2017) 139: 232-241 [PMID:28802123] |
| ChEMBL | Inhibition of Kv1.5 (unknown origin) | B | 7.35 | pEC50 | 45 | nM | EC50 | US-20060079535-A1. 5-phenoxyalkoxypsoralens and methods for selective inhibition of the voltage gated kv1.3 potassium channel (2006) |
| Kv1.6/Voltage-gated potassium channel subunit Kv1.6 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5279] [GtoPdb: 543] [UniProtKB: P17658] | ||||||||
| ChEMBL | Inhibition of human Kv1.6 expressed in CHO cells at -80 mV holding potential by whole cell automated patch clamp method | B | 6.89 | pIC50 | 130 | nM | IC50 | Eur J Med Chem (2017) 139: 232-241 [PMID:28802123] |
| Kv1.7/Voltage-gated potassium channel subunit Kv1.7 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2773] [GtoPdb: 544] [UniProtKB: Q96RP8] | ||||||||
| ChEMBL | Inhibition of Kv1.7 (unknown origin) | B | 7.01 | pEC50 | 98 | nM | EC50 | US-20060079535-A1. 5-phenoxyalkoxypsoralens and methods for selective inhibition of the voltage gated kv1.3 potassium channel (2006) |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
