5-(4-phenoxybutoxy)psoralen [Ligand Id: 2554] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL444449 (5-(4-Phenoxybutoxy)Psoralen) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| KCa1.1/Calcium-activated potassium channel subunit alpha-1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4304] [GtoPdb: 380] [UniProtKB: Q12791] | ||||||||
| ChEMBL | Inhibition of BK (unknown origin) | B | 5.82 | pEC50 | 1500 | nM | EC50 | US-20060079535-A1. 5-phenoxyalkoxypsoralens and methods for selective inhibition of the voltage gated kv1.3 potassium channel (2006) |
| Kv11.1/HERG in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL240] [GtoPdb: 572] [UniProtKB: Q12809] | ||||||||
| ChEMBL | Inhibition of human ERG | B | 5.3 | pEC50 | 5000 | nM | EC50 | US-20060079535-A1. 5-phenoxyalkoxypsoralens and methods for selective inhibition of the voltage gated kv1.3 potassium channel (2006) |
| KCa3.1/Intermediate conductance calcium-activated potassium channel protein 4 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4305] [GtoPdb: 384] [UniProtKB: O15554] | ||||||||
| ChEMBL | Inhibition of human cloned IK1 expressed in african green monkey COS7 cells by whole cell patch clamp assay | B | 5 | pIC50 | 10000 | nM | IC50 | Bioorg Med Chem Lett (2009) 19: 2299-2304 [PMID:19282171] |
| ChEMBL | Inhibition of IKCa1 (unknown origin) | B | 5 | pEC50 | 10000 | nM | EC50 | US-20060079535-A1. 5-phenoxyalkoxypsoralens and methods for selective inhibition of the voltage gated kv1.3 potassium channel (2006) |
| KCa2.1/Small conductance calcium-activated potassium channel protein 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2369] [GtoPdb: 381] [UniProtKB: Q92952] | ||||||||
| ChEMBL | Inhibition of SKCa1 (unknown origin) | B | 5.3 | pEC50 | 5000 | nM | EC50 | US-20060079535-A1. 5-phenoxyalkoxypsoralens and methods for selective inhibition of the voltage gated kv1.3 potassium channel (2006) |
| KCa2.2/Small conductance calcium-activated potassium channel protein 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4469] [GtoPdb: 382] [UniProtKB: Q9H2S1] | ||||||||
| ChEMBL | Inhibition of SKCa2 (unknown origin) | B | 5.3 | pEC50 | 5000 | nM | EC50 | US-20060079535-A1. 5-phenoxyalkoxypsoralens and methods for selective inhibition of the voltage gated kv1.3 potassium channel (2006) |
| Kv1.1/Voltage-gated potassium channel subunit Kv1.1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2309] [GtoPdb: 538] [UniProtKB: Q09470] | ||||||||
| ChEMBL | Inhibition of human Kv1.1 expressed in CHO cells at -80 mV holding potential by whole cell automated patch clamp method | B | 6.6 | pIC50 | 250 | nM | IC50 | Eur J Med Chem (2017) 139: 232-241 [PMID:28802123] |
| ChEMBL | Inhibition of Kv1.1 (unknown origin) | B | 7.19 | pEC50 | 65 | nM | EC50 | US-20060079535-A1. 5-phenoxyalkoxypsoralens and methods for selective inhibition of the voltage gated kv1.3 potassium channel (2006) |
| Kv1.2/Voltage-gated potassium channel subunit Kv1.2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2086] [GtoPdb: 539] [UniProtKB: P16389] | ||||||||
| ChEMBL | Inhibition of human Kv1.2 expressed in CHO cells at -80 mV holding potential by whole cell automated patch clamp method | B | 6.35 | pIC50 | 450 | nM | IC50 | Eur J Med Chem (2017) 139: 232-241 [PMID:28802123] |
| ChEMBL | Inhibition of Kv1.2 (unknown origin) | B | 6.6 | pEC50 | 250 | nM | EC50 | US-20060079535-A1. 5-phenoxyalkoxypsoralens and methods for selective inhibition of the voltage gated kv1.3 potassium channel (2006) |
| Kv1.3/Voltage-gated potassium channel subunit Kv1.3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4633] [GtoPdb: 540] [UniProtKB: P22001] | ||||||||
| ChEMBL | Inhibition of human Kv1.3 ion channel expressed in CGE22 cells | B | 6.13 | pIC50 | 740 | nM | IC50 | Bioorg Med Chem Lett (2010) 20: 6989-6992 [PMID:20974533] |
| ChEMBL | Inhibition of human Kv1.3 expressed in CHO cells at -80 mV holding potential by whole cell automated patch clamp method | B | 7.62 | pIC50 | 24 | nM | IC50 | Eur J Med Chem (2017) 139: 232-241 [PMID:28802123] |
| ChEMBL | Inhibition of cloned Kv1.3 channel expressed in mammalian cells by whole cell patch clamp assay | B | 8 | pIC50 | 10 | nM | IC50 | Bioorg Med Chem Lett (2009) 19: 2299-2304 [PMID:19282171] |
| ChEMBL | Inhibition of Kv1.3 potassium channel expressed in mouse L929 cells by whole cell patch clamp | B | 8.7 | pIC50 | 2 | nM | IC50 | Eur J Med Chem (2009) 44: 1838-1852 [PMID:19056148] |
| ChEMBL | Inhibition of Kv1.3 expressed in mouse L929 cells exposed to depolarizing step pulses from -80 mV to +40 mV by whole cell patch clamp method | B | 8.7 | pIC50 | 2 | nM | IC50 | Bioorg Med Chem Lett (2012) 22: 7106-7109 [PMID:23084278] |
| ChEMBL | Inhibition of Kv1.3 (unknown origin) | B | 8.7 | pEC50 | 2 | nM | EC50 | US-20060079535-A1. 5-phenoxyalkoxypsoralens and methods for selective inhibition of the voltage gated kv1.3 potassium channel (2006) |
| Kv1.3 in Mouse [GtoPdb: 540] [UniProtKB: P16390] | ||||||||
| GtoPdb | - | - | 8.7 | pEC50 | - | - | - | Mol Pharmacol (2005) 68: 1254-70 [PMID:16099841] |
| Kv1.4/Voltage-gated potassium channel subunit Kv1.4 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4205] [GtoPdb: 541] [UniProtKB: P22459] | ||||||||
| ChEMBL | Inhibition of human Kv1.4 expressed in CHO cells at -80 mV holding potential by whole cell automated patch clamp method | B | 6.77 | pIC50 | 170 | nM | IC50 | Eur J Med Chem (2017) 139: 232-241 [PMID:28802123] |
| ChEMBL | Inhibition of Kv1.4 (unknown origin) | B | 7.12 | pEC50 | 75 | nM | EC50 | US-20060079535-A1. 5-phenoxyalkoxypsoralens and methods for selective inhibition of the voltage gated kv1.3 potassium channel (2006) |
| Kv1.5/Voltage-gated potassium channel subunit Kv1.5 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4306] [GtoPdb: 542] [UniProtKB: P22460] | ||||||||
| ChEMBL | Inhibition of human Kv1.5 ion channel expressed in CHO K1 cells | B | 5.46 | pIC50 | 3450 | nM | IC50 | Bioorg Med Chem Lett (2010) 20: 6989-6992 [PMID:20974533] |
| ChEMBL | Inhibition of human Kv1.5 expressed in CHO cells at -80 mV holding potential by whole cell automated patch clamp method | B | 7.06 | pIC50 | 88 | nM | IC50 | Eur J Med Chem (2017) 139: 232-241 [PMID:28802123] |
| ChEMBL | Inhibition of Kv1.5 (unknown origin) | B | 7.35 | pEC50 | 45 | nM | EC50 | US-20060079535-A1. 5-phenoxyalkoxypsoralens and methods for selective inhibition of the voltage gated kv1.3 potassium channel (2006) |
| Kv1.6/Voltage-gated potassium channel subunit Kv1.6 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5279] [GtoPdb: 543] [UniProtKB: P17658] | ||||||||
| ChEMBL | Inhibition of human Kv1.6 expressed in CHO cells at -80 mV holding potential by whole cell automated patch clamp method | B | 6.89 | pIC50 | 130 | nM | IC50 | Eur J Med Chem (2017) 139: 232-241 [PMID:28802123] |
| Kv1.7/Voltage-gated potassium channel subunit Kv1.7 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2773] [GtoPdb: 544] [UniProtKB: Q96RP8] | ||||||||
| ChEMBL | Inhibition of Kv1.7 (unknown origin) | B | 7.01 | pEC50 | 98 | nM | EC50 | US-20060079535-A1. 5-phenoxyalkoxypsoralens and methods for selective inhibition of the voltage gated kv1.3 potassium channel (2006) |
ChEMBL data shown on this page come from version 34:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
