ChEMBL ligand: CHEMBL65061 (Leukotriene B4)
BLT1 receptor/Leukotriene B4 receptor 1 in Human [ChEMBL: CHEMBL3911] [GtoPdb: 267] [UniProtKB: Q15722] There should be some charts here, you may need to enable JavaScript!
BLT2 receptor in Human [GtoPdb: 268] [UniProtKB: Q9NPC1] There should be some charts here, you may need to enable JavaScript!
TRPV1 in Rat [GtoPdb: 507] [UniProtKB: O35433] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
BLT1 receptor/Leukotriene B4 receptor 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3911] [GtoPdb: 267] [UniProtKB: Q15722]
ChEMBL	Displacement of [3H]LTB4 from LTB4R	B	8.54	pKi	2.9	nM	Ki	J Nat Prod (1993) 56: 441-455 [PMID:8496700]
ChEMBL	Tested for inhibition of specific binding of [3H]LTB4 to human neutrophil expressing LTB4 receptor	B	8.72	pKi	1.9	nM	Ki	J Med Chem (1993) 36: 3982-3984 [PMID:8254628]
ChEMBL	LTB4 receptor antagonist activity was determined by inhibition of specific binding of [3H]LTB4 in human neutrophil	B	8.72	pKi	1.9	nM	Ki	Bioorg Med Chem Lett (1994) 4: 2077-2082
GtoPdb	-	-	9.4	pKi	0.38	nM	Ki
ChEMBL	Tested for inhibition of specific binding of [3H]LTB4 to guinea pig lung membranes expressing LTB4 receptor	B	9.92	pKi	0.12	nM	Ki	J Med Chem (1993) 36: 3982-3984 [PMID:8254628]
ChEMBL	Compound was evaluated for inhibition of binding of [3H]LTB4 to LTB4 receptor in guinea-pig lung membranes	B	9.92	pKi	0.12	nM	Ki	Bioorg Med Chem Lett (1993) 3: 1981-1984
ChEMBL	LTB4 receptor antagonist activity was determined by inhibition of specific binding of [3H]LTB4 in guinea pig lung membranes	B	9.92	pKi	0.12	nM	Ki	Bioorg Med Chem Lett (1994) 4: 2077-2082
ChEMBL	Inhibitory activity against leukotriene B4 receptor	B	7.49	pIC50	32	nM	IC50	Bioorg Med Chem Lett (1994) 4: 811-816
ChEMBL	In vitro antagonistic activity towards LTB4 receptor was evaluated by inhibition of binding of [3H]LTB4 to human neutrophils	B	8.72	pIC50	1.9	nM	IC50	Bioorg Med Chem Lett (1993) 3: 1981-1984
ChEMBL	Inhibition of specific binding of [3H]LTB4 to Leukotriene B4 receptor in human neutrophils	B	8.72	pIC50	1.9	nM	IC50	J Med Chem (1990) 33: 2807-2813 [PMID:2170648]
BLT2 receptor in Human [GtoPdb: 268] [UniProtKB: Q9NPC1]
GtoPdb	-	-	7.64	pKd	22.7	nM	Kd	J Exp Med (2000) 192: 421-32 [PMID:10934230]
GtoPdb	-	-	7.6	pIC50	25	nM	IC50	J Exp Med (2008) 205: 759-66 [PMID:18378794]
GtoPdb	-	-	6.85	pEC50	142	nM	EC50	J Exp Med (2008) 205: 759-66 [PMID:18378794]
TRPV1 in Rat [GtoPdb: 507] [UniProtKB: O35433]
GtoPdb	-	-	4.9	pEC50	12500	nM	EC50	Proc Natl Acad Sci USA (2000) 97: 6155-60 [PMID:10823958]

ChEMBL data shown on this page come from version 33:

Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]