ChEMBL ligand: CHEMBL65061 (Leukotriene B4)
BLT1 receptor/Leukotriene B4 receptor 1 in Human [ChEMBL: CHEMBL3911] [GtoPdb: 267] [UniProtKB: Q15722] There should be some charts here, you may need to enable JavaScript!
BLT2 receptor in Human [GtoPdb: 268] [UniProtKB: Q9NPC1] There should be some charts here, you may need to enable JavaScript!
TRPV1 in Rat [GtoPdb: 507] [UniProtKB: O35433] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
BLT1 receptor/Leukotriene B4 receptor 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3911] [GtoPdb: 267] [UniProtKB: Q15722]
ChEMBL	Displacement of [3H]LTB4 from LTB4R	B	8.54	pKi	2.9	nM	Ki	J Nat Prod (1993) 56: 441-455 [PMID:8496700]
ChEMBL	Tested for inhibition of specific binding of [3H]LTB4 to human neutrophil expressing LTB4 receptor	B	8.72	pKi	1.9	nM	Ki	J Med Chem (1993) 36: 3982-3984 [PMID:8254628]
ChEMBL	LTB4 receptor antagonist activity was determined by inhibition of specific binding of [3H]LTB4 in human neutrophil	B	8.72	pKi	1.9	nM	Ki	Bioorg Med Chem Lett (1994) 4: 2077-2082
GtoPdb	-	-	9.4	pKi	0.38	nM	Ki
ChEMBL	Tested for inhibition of specific binding of [3H]LTB4 to guinea pig lung membranes expressing LTB4 receptor	B	9.92	pKi	0.12	nM	Ki	J Med Chem (1993) 36: 3982-3984 [PMID:8254628]
ChEMBL	Compound was evaluated for inhibition of binding of [3H]LTB4 to LTB4 receptor in guinea-pig lung membranes	B	9.92	pKi	0.12	nM	Ki	Bioorg Med Chem Lett (1993) 3: 1981-1984
ChEMBL	LTB4 receptor antagonist activity was determined by inhibition of specific binding of [3H]LTB4 in guinea pig lung membranes	B	9.92	pKi	0.12	nM	Ki	Bioorg Med Chem Lett (1994) 4: 2077-2082
ChEMBL	Inhibitory activity against leukotriene B4 receptor	B	7.49	pIC50	32	nM	IC50	Bioorg Med Chem Lett (1994) 4: 811-816
ChEMBL	In vitro antagonistic activity towards LTB4 receptor was evaluated by inhibition of binding of [3H]LTB4 to human neutrophils	B	8.72	pIC50	1.9	nM	IC50	Bioorg Med Chem Lett (1993) 3: 1981-1984
ChEMBL	Inhibition of specific binding of [3H]LTB4 to Leukotriene B4 receptor in human neutrophils	B	8.72	pIC50	1.9	nM	IC50	J Med Chem (1990) 33: 2807-2813 [PMID:2170648]
BLT2 receptor in Human [GtoPdb: 268] [UniProtKB: Q9NPC1]
GtoPdb	-	-	7.64	pKd	22.7	nM	Kd	J Exp Med (2000) 192: 421-32 [PMID:10934230]
GtoPdb	-	-	7.6	pIC50	25	nM	IC50	J Exp Med (2008) 205: 759-66 [PMID:18378794]
GtoPdb	-	-	6.85	pEC50	142	nM	EC50	J Exp Med (2008) 205: 759-66 [PMID:18378794]
TRPV1 in Rat [GtoPdb: 507] [UniProtKB: O35433]
GtoPdb	-	-	4.9	pEC50	12500	nM	EC50	Proc Natl Acad Sci USA (2000) 97: 6155-60 [PMID:10823958]

ChEMBL data shown on this page come from version 34:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]