ChEMBL ligand: CHEMBL470670 (Levomenthol, Levomentol, L-menthol)
TRPA1/Transient receptor potential cation channel subfamily A member 1 in Human [ChEMBL: CHEMBL6007] [GtoPdb: 485] [UniProtKB: O75762] TRPA1 in Mouse [GtoPdb: 485] [UniProtKB: Q8BLA8] There should be some charts here, you may need to enable JavaScript!
TRPM8/Transient receptor potential cation channel subfamily M member 8 in Human [ChEMBL: CHEMBL1075319] [GtoPdb: 500] [UniProtKB: Q7Z2W7] TRPM8 in Mouse [GtoPdb: 500] [UniProtKB: Q8R4D5] TRPM8 in Rat [GtoPdb: 500] [UniProtKB: Q8R455] There should be some charts here, you may need to enable JavaScript!
Voltage-dependent L-type calcium channel subunit alpha-1C in Rabbit [ChEMBL: CHEMBL2830] [UniProtKB: P15381] There should be some charts here, you may need to enable JavaScript!
TRPV3 in Mouse [GtoPdb: 509] [UniProtKB: Q8K424] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
TRPA1/Transient receptor potential cation channel subfamily A member 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL6007] [GtoPdb: 485] [UniProtKB: O75762]
ChEMBL	Agonist activity at recombinant human TRPA1 expressed in HEK293 cells assessed as increase in intracellular Ca2+ level pre-incubated for 5 mins by Fluo4-AM dye-based fluorescence assay	B	4.02	pEC50	96000	nM	EC50	ACS Med Chem Lett (2017) 8: 715-719 [PMID:28740604]
GtoPdb	Calcium imaging, patch clamp	-	4.5	pEC50	28400	nM	EC50	J Neurosci (2008) 28: 9640-51 [PMID:18815250]; J Neurosci (2007) 27: 9874-84 [PMID:17855602]
TRPA1 in Mouse [GtoPdb: 485] [UniProtKB: Q8BLA8]
GtoPdb	-	-	4.2	pIC50	-	-	-	Mol Cell Neurosci (2006) 32: 335-43 [PMID:16829128]
TRPM8/Transient receptor potential cation channel subfamily M member 8 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1075319] [GtoPdb: 500] [UniProtKB: Q7Z2W7]
ChEMBL	Agonist activity at TRPM8 (unknown origin) by fluorometric imaging plate reader analysis	B	4.22	pEC50	60000	nM	EC50	J Med Chem (2016) 59: 10006-10029 [PMID:27437828]
GtoPdb	-	-	4.6	pEC50	25100	nM	EC50	Nature (2004) 430: 748-54 [PMID:15306801]
ChEMBL	Agonist activity at full length recombinant human TRPM8 expressed in HEK293 cells assessed as increase in intracellular Ca2+ level pre-incubated for 5 mins by Fluo4-AM dye-based fluorescence assay	B	5	pEC50	10100	nM	EC50	ACS Med Chem Lett (2017) 8: 715-719 [PMID:28740604]
ChEMBL	TRPM8 receptor assay: In the first set of data, the potency and in vitro effects of test compounds were evaluated on cloned hTRPM8 channel (encoded by the human TRPM8 gene, expressed in CHO cells) using a Fluo-8 calcium kit and a Fluorescence Imaging Plate Reader (FLIPRTETRA™) instrument. The assays were conducted by ChanTest Corporation (Cleveland, Ohio 44128, USA). Test solutions were in a HEPES-buffered saline, in 384-well plates, and placed into the FLIPR instrument (Molecular Devices Corporation, Union City, Calif., USA). Four 4 to 8 concentrations were tested, with L-menthol as the positive control. The test cells were Chinese Hamster Ovary (CHO) cells stably transfected with human TRPM8 cDNAs. Concentration-response data were analyzed via FLIPR Control software) and fitted to a Hill equation for the EC50. The 95% Confidence Interval was obtained using GraphPad Prism 6 software.	B	5.42	pEC50	3800	nM	EC50	US-11406649-B2. Treatment of upper aerodigestive tract disorders and cough (2022)
TRPM8 in Mouse [GtoPdb: 500] [UniProtKB: Q8R4D5]
GtoPdb	-	-	5.4	pEC50	-	-	-	J Neurosci (2004) 24: 5364-9 [PMID:15190109]; Br J Pharmacol (2004) 141: 737-45 [PMID:14757700]
TRPM8 in Rat [GtoPdb: 500] [UniProtKB: Q8R455]
GtoPdb	-	-	4.2	pEC50	-	-	-	Nature (2002) 416: 52-8 [PMID:11882888]
Voltage-dependent L-type calcium channel subunit alpha-1C in Rabbit (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2830] [UniProtKB: P15381]
ChEMBL	Inhibition of Cav1.2 calcium current measured using whole cell patch clamp in rabbit ventricular myocytes	F	4.13	pIC50	74600	nM	IC50	IC50 data for the L-type calcium channel extracted from a set of literature articles
TRPV3 in Mouse [GtoPdb: 509] [UniProtKB: Q8K424]
GtoPdb	Patch clamp electrophysiology and calcium imaging	-	1.7	pEC50	19952624	nM	EC50	Mol Cell Neurosci (2006) 32: 335-43 [PMID:16829128]

ChEMBL data shown on this page come from version 36:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]