(-)-menthol [Ligand Id: 2430] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL470670 (Levomenthol, L-menthol) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| TRPA1/Transient receptor potential cation channel subfamily A member 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL6007] [GtoPdb: 485] [UniProtKB: O75762] | ||||||||
| ChEMBL | Agonist activity at recombinant human TRPA1 expressed in HEK293 cells assessed as increase in intracellular Ca2+ level pre-incubated for 5 mins by Fluo4-AM dye-based fluorescence assay | B | 4.02 | pEC50 | 96000 | nM | EC50 | ACS Med Chem Lett (2017) 8: 715-719 [PMID:28740604] |
| GtoPdb | Calcium imaging, patch clamp | - | 4.5 | pEC50 | 28400 | nM | EC50 |
J Neurosci (2008) 28: 9640-51 [PMID:18815250]; J Neurosci (2007) 27: 9874-84 [PMID:17855602] |
| TRPA1 in Mouse [GtoPdb: 485] [UniProtKB: Q8BLA8] | ||||||||
| GtoPdb | - | - | 4.2 | pIC50 | - | - | - | Mol Cell Neurosci (2006) 32: 335-43 [PMID:16829128] |
| TRPM8/Transient receptor potential cation channel subfamily M member 8 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1075319] [GtoPdb: 500] [UniProtKB: Q7Z2W7] | ||||||||
| GtoPdb | - | - | 4.6 | pEC50 | 25100 | nM | EC50 | Nature (2004) 430: 748-54 [PMID:15306801] |
| ChEMBL | Agonist activity at full length recombinant human TRPM8 expressed in HEK293 cells assessed as increase in intracellular Ca2+ level pre-incubated for 5 mins by Fluo4-AM dye-based fluorescence assay | B | 5 | pEC50 | 10100 | nM | EC50 | ACS Med Chem Lett (2017) 8: 715-719 [PMID:28740604] |
| TRPM8 in Mouse [GtoPdb: 500] [UniProtKB: Q8R4D5] | ||||||||
| GtoPdb | - | - | 5.4 | pEC50 | - | - | - |
J Neurosci (2004) 24: 5364-9 [PMID:15190109]; Br J Pharmacol (2004) 141: 737-45 [PMID:14757700] |
| TRPM8 in Rat [GtoPdb: 500] [UniProtKB: Q8R455] | ||||||||
| GtoPdb | - | - | 4.2 | pEC50 | - | - | - | Nature (2002) 416: 52-8 [PMID:11882888] |
| Voltage-gated L-type calcium channel alpha-1C subunit in Rabbit (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2830] [UniProtKB: P15381] | ||||||||
| ChEMBL | Inhibition of Cav1.2 calcium current measured using whole cell patch clamp in rabbit ventricular myocytes | F | 4.13 | pIC50 | 74600 | nM | IC50 | IC50 data for the L-type calcium channel extracted from a set of literature articles |
| TRPV3 in Mouse [GtoPdb: 509] [UniProtKB: Q8K424] | ||||||||
| GtoPdb | Patch clamp electrophysiology and calcium imaging | - | 1.7 | pEC50 | 19952624 | nM | EC50 | Mol Cell Neurosci (2006) 32: 335-43 [PMID:16829128] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
