ChEMBL ligand: CHEMBL293492 (Abion ca, .beta.-phenylacrolein, Cinnamal, Cinnamaldehyde, Cinnamic aldehyde, FEMA NO. 2286, NSC-16935, NSC-40346, XC-800, Zimtaldehyde)
5-LOX/Arachidonate 5-lipoxygenase in Human [ChEMBL: CHEMBL215] [GtoPdb: 1385] [UniProtKB: P09917] There should be some charts here, you may need to enable JavaScript!
Cell division protein ftsZ in Escherichia coli [ChEMBL: CHEMBL3999] [UniProtKB: P0A9A6] There should be some charts here, you may need to enable JavaScript!
TRPA1/Transient receptor potential cation channel subfamily A member 1 in Human [ChEMBL: CHEMBL6007] [GtoPdb: 485] [UniProtKB: O75762] TRPA1/Transient receptor potential cation channel subfamily A member 1 in Mouse [ChEMBL: CHEMBL1075310] [GtoPdb: 485] [UniProtKB: Q8BLA8] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
5-LOX/Arachidonate 5-lipoxygenase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL215] [GtoPdb: 1385] [UniProtKB: P09917]
ChEMBL	Inhibition of human PMNL 5-LOX using arachidonic acid as substrate after 5 mins by HPLC method	B	4.46	pIC50	35000	nM	IC50	Bioorg Med Chem (2019) 27: 3745-3759 [PMID:31331653]
Cell division protein ftsZ in Escherichia coli (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3999] [UniProtKB: P0A9A6]
ChEMBL	Inhibition of Escherichia coli FtsZ polymerization	B	5.16	pIC50	6860	nM	IC50	Eur J Med Chem (2015) 95: 1-15 [PMID:25791674]
ChEMBL	Inhibition of Escherichia coli FtsZ GTPase activity	B	5.24	pIC50	5810	nM	IC50	Eur J Med Chem (2015) 95: 1-15 [PMID:25791674]
TRPA1/Transient receptor potential cation channel subfamily A member 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL6007] [GtoPdb: 485] [UniProtKB: O75762]
ChEMBL	Agonist activity at human TRPA1 expressed in HEK293 cells assessed as [45]Ca2+ influx by microbeta plate count	F	4.29	pEC50	51400	nM	EC50	Bioorg Med Chem Lett (2010) 20: 276-279 [PMID:19945872]
ChEMBL	Activation of TRPA1	B	4.72	pEC50	19000	nM	EC50	Nature (2007) 445: 541-545 [PMID:17237762]
ChEMBL	Agonist activity at human TRPA1 expressed in HEK293 cells assessed as increase in calcium influx by Fluo-4-AM dye based fluorescence assay	B	5.05	pEC50	9000	nM	EC50	Eur J Med Chem (2019) 170: 141-156 [PMID:30878828]
ChEMBL	Agonist activity at human TRPA1 expressed in HEK293 cells assessed as increase in calcium influx by Fluo-4-AM dye based fluorescence assay	B	5.07	pEC50	8511.38	nM	EC50	Eur J Med Chem (2019) 170: 141-156 [PMID:30878828]
ChEMBL	Activation of TRPA1 channel expressed in CHO cells assessed as increase in intracellular calcium levels	B	5.19	pEC50	6500	nM	EC50	J Med Chem (2010) 53: 5085-5107 [PMID:20356305]
TRPA1/Transient receptor potential cation channel subfamily A member 1 in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1075310] [GtoPdb: 485] [UniProtKB: Q8BLA8]
GtoPdb	-	-	4.2	pEC50	63000	nM	EC50	Neuron (2004) 41: 849-57 [PMID:15046718]
ChEMBL	Agonist activity at mouse TRPA1 expressed in CHO cells assessed as increase in calcium influx by Fluo-3 based FLIPR analysis	B	4.21	pEC50	61000	nM	EC50	Eur J Med Chem (2019) 170: 141-156 [PMID:30878828]

ChEMBL data shown on this page come from version 33:

Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]