cyclic GMP [Ligand Id: 2347] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL395336 (cyclic GMP) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| Phosphodiesterase 3B in Bovine (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5129] [UniProtKB: E1BN64] | ||||||||
| ChEMBL | Inhibition of bovine arterial Phosphodiesterase 3 | B | 7 | pIC50 | 100 | nM | IC50 | J Med Chem (1996) 39: 297-303 [PMID:8568820] |
| CNGA1 in Human [GtoPdb: 394] [UniProtKB: P29973] | ||||||||
| GtoPdb | - | - | 4.22 | pKi | 60000 | nM | Ki |
Proc Natl Acad Sci USA (1994) 91: 11757-61 [PMID:7526403]; J Neurosci (1992) 12: 3248-56 [PMID:1379636]; Proc Natl Acad Sci USA (1995) 92: 10177-81 [PMID:7479749]; Biophys J (1998) 74: 1333-45 [PMID:9512030]; Neuron (1995) 14: 177-83 [PMID:7530019]; J Gen Physiol (1999) 113: 17-34 [PMID:9874685]; Neuron (2002) 36: 891-6 [PMID:12467592] |
| CNGA2 in Rat [GtoPdb: 395] [UniProtKB: Q00195] | ||||||||
| GtoPdb | - | - | 5.76 | pEC50 | 1740 | nM | EC50 |
Neuron (1994) 13: 611-21 [PMID:7522482]; Proc Natl Acad Sci USA (1994) 91: 8890-4 [PMID:7522325]; Sci Signal (2012) 5: ra48 [PMID:22786723] |
| CNGA3 in Human [GtoPdb: 396] [UniProtKB: Q16281] | ||||||||
| GtoPdb | - | - | 5.6 | pKd | - | - | - |
FEBS Lett (1996) 393: 211-5 [PMID:8814292]; Eur J Neurosci (1997) 9: 2512-21 [PMID:9517456]; J Biol Chem (2003) 278: 24617-23 [PMID:12730238] |
| CNGA3 in Rat [GtoPdb: 396] | ||||||||
| GtoPdb | - | - | 5.51 | pKd | - | - | - | J Neurophysiol (2001) 85: 2335-49 [PMID:11387380] |
| HCN2 in Mouse [GtoPdb: 401] [UniProtKB: O88703] | ||||||||
| GtoPdb | - | - | 5.2 | pKi | - | - | - | Nature (1998) 393: 587-91 [PMID:9634236] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
